{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T16:54:07Z","timestamp":1781456047768,"version":"3.54.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Sanofi & Astra Zeneca"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Nirsevimab was implemented in Europe and the United States in September 2023. While its effectiveness in preventing respiratory syncytial virus (RSV)-bronchiolitis has been demonstrated by real-life studies, its impact on mid-term child health, quality of life, and parental absenteeism remains unstudied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Infants under 1-year with a first bronchiolitis episode were recruited through the OURSYN study involving 37 primary care pediatricians in France between 2021 and 2025 (pre-nirsevimab period: 02\/2021-03\/2023 and nirsevimab period: 09\/2023-03\/2025). RSV status was determined by antigenic nasopharyngeal testing. At day 15, parents reported symptoms, quality of life (PedsQL Infant), and work absenteeism. Their associations with (i) RSV status, (ii) period of inclusion, and (iii) nirsevimab immunization status among RSV-positive cases were assessed using multivariable logistic regression adjusted for confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 1870 bronchiolitis cases included, 637 (34.0%) occurred during the nirsevimab period and 812 (43.4%) were RSV-related. Over the study period, at day 15, RSV-cases had more feeding difficulties (aOR\u2009=\u20091.41 [1.06-1.88]), longer daycare absence (4.7 vs. 3.2\u00a0days), and more parental absenteeism (aOR\u2009=\u20091.61 [0.99-2.62]) compared to RSV-negative. The proportion of RSV-cases decreased during the nirsevimab period compared with the pre-nirsevimab period (47.1% vs. 35.7% P\u2009&amp;lt;\u2009.001). Bronchiolitis cases recruited during this period had shorter daycare absences (3.2 vs. 4.3\u00a0days). Among RSV-cases, immunized infants had lower risk of persistent fever (aOR\u2009=\u20090.14 [0.01-0.79]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This large prospective study provides the first evidence that the mid-term burden of RSV-bronchiolitis in infants may be reduced following the implementation of nirsevimab, with potential benefits for infant health, quality of life and parental absenteeism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jpids\/piag035","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T12:15:35Z","timestamp":1778674535000},"source":"Crossref","is-referenced-by-count":0,"title":["Impact of Nirsevimab Implementation on the Mid-Term Burden of Bronchiolitis in the Outpatient Setting: Results from the Prospective OURSYN Study"],"prefix":"10.1093","volume":"15","author":[{"given":"Lea","family":"Lenglart","sequence":"first","affiliation":[{"name":"Pediatric Emergency Department, Robert Debr\u00e9 Hospital, Assistance Publique-H\u00f4pitaux de Paris , Paris ,","place":["France"]},{"name":"IAME (Infection, Antimicrobials, Modelling, Evolution), INSERM UMR 1137, Paris Cit\u00e9 University , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1927-6360","authenticated-orcid":false,"given":"Corinne","family":"Levy","sequence":"additional","affiliation":[{"name":"Association Clinique et Th\u00e9rapeutique Infantile du Val de Marne (ACTIV), Cr\u00e9teil , Paris ,","place":["France"]},{"name":"IMRB-GRC GEMINI; Universit\u00e9 Paris Est, Cr\u00e9teil , Paris ,","place":["France"]},{"name":"Clinical Research Center (CRC), Centre Hospitalier Intercommunal de Cr\u00e9teil , Paris ,","place":["France"]},{"name":"Groupe de pathologie infectieuse p\u00e9diatrique (GPIP) , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Cahn-Sellem","sequence":"additional","affiliation":[{"name":"Association Fran\u00e7aise de P\u00e9diatrie Ambulatoire (AFPA) , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morched","family":"Zouari","sequence":"additional","affiliation":[{"name":"Association Fran\u00e7aise de P\u00e9diatrie Ambulatoire (AFPA) , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Hassid","sequence":"additional","affiliation":[{"name":"Association Fran\u00e7aise de P\u00e9diatrie Ambulatoire (AFPA) , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"B\u00e9chet","sequence":"additional","affiliation":[{"name":"Association Clinique et Th\u00e9rapeutique Infantile du Val de Marne (ACTIV), Cr\u00e9teil , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maeva","family":"Boulhol","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department, Robert Debr\u00e9 Hospital, Assistance Publique-H\u00f4pitaux de Paris , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6095-4338","authenticated-orcid":false,"given":"Rolf","family":"Kramer","sequence":"additional","affiliation":[{"name":"Sanofi Pasteur , Lyon ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Rybak","sequence":"additional","affiliation":[{"name":"Association Clinique et Th\u00e9rapeutique Infantile du Val de Marne (ACTIV), Cr\u00e9teil , Paris ,","place":["France"]},{"name":"Groupe de pathologie infectieuse p\u00e9diatrique (GPIP) , Paris ,","place":["France"]},{"name":"Department of Pediatrics, Lausanne University Hospital (Centre Hospitalier Universitaire Vaudois) , Lausanne, Vaud ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naim","family":"Ouldali","sequence":"additional","affiliation":[{"name":"IAME (Infection, Antimicrobials, Modelling, Evolution), INSERM UMR 1137, Paris Cit\u00e9 University , Paris ,","place":["France"]},{"name":"Groupe de pathologie infectieuse p\u00e9diatrique (GPIP) , Paris ,","place":["France"]},{"name":"Department of General Pediatrics, Pediatric Infectious Disease and Internal Medicine, Robert Debr\u00e9 University Hospital, Assistance Publique-H\u00f4pitaux de Paris , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6151-0686","authenticated-orcid":false,"given":"Robert","family":"Cohen","sequence":"additional","affiliation":[{"name":"Association Clinique et Th\u00e9rapeutique Infantile du Val de Marne (ACTIV), Cr\u00e9teil , Paris ,","place":["France"]},{"name":"IMRB-GRC GEMINI; Universit\u00e9 Paris Est, Cr\u00e9teil , Paris ,","place":["France"]},{"name":"Clinical Research Center (CRC), Centre Hospitalier Intercommunal de Cr\u00e9teil , Paris ,","place":["France"]},{"name":"Groupe de pathologie infectieuse p\u00e9diatrique (GPIP) , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,18]]},"reference":[{"key":"2026061319190240100_ref1","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.1016\/S0140-6736(22)00478-0","article-title":"Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis","volume":"399","author":"Li","year":"2022","journal-title":"Lancet"},{"key":"2026061319190240100_ref2","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1093\/infdis\/jiad188","article-title":"Burden of respiratory syncytial virus in the European Union: estimation of RSV-associated hospitalizations in children under 5 years","volume":"228","author":"Del Riccio","year":"2023","journal-title":"J Infect Dis"},{"key":"2026061319190240100_ref3","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1186\/s12879-021-06399-8","article-title":"Economic and disease burden of RSV-associated hospitalizations in young children in France, from 2010 through 2018","volume":"21","author":"Demont","year":"2021","journal-title":"BMC Infect Dis"},{"key":"2026061319190240100_ref4","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1542\/peds.2007-2087","article-title":"Increasing burden and risk factors for bronchiolitis-related medical visits in infants enrolled in a state health care insurance plan","volume":"122","author":"Carroll","year":"2008","journal-title":"Pediatrics"},{"key":"2026061319190240100_ref5","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1186\/s12879-025-12039-2","article-title":"Epidemiology and economic burden of hospitalizations attributable to respiratory syncytial virus (RSV) infection among infants in France, 2016 to 2023\u2014EPIBREATHE study","volume":"25","author":"Cohen","year":"2025","journal-title":"BMC Infect Dis"},{"key":"2026061319190240100_ref6","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1186\/s12879-023-08358-x","article-title":"Clinical and economic hospital burden of acute respiratory infection (BARI) due to respiratory syncytial virus in Spanish children, 2015\u20132018","volume":"23","author":"Martin\u00f3n-Torres","year":"2023","journal-title":"BMC Infect Dis"},{"key":"2026061319190240100_ref7","doi-asserted-by":"publisher","first-page":"e13066","DOI":"10.1111\/irv.13066","article-title":"Burden and severity of children\u2019s hospitalizations by respiratory syncytial virus in Portugal, 2015\u20132018","volume":"17","author":"Bandeira","year":"2023","journal-title":"Influenza Other Respir Viruses"},{"key":"2026061319190240100_ref8","doi-asserted-by":"crossref","first-page":"108141","DOI":"10.1016\/j.ijid.2025.108141","article-title":"Elucidating the outpatient burden of lower respiratory tract infections due to RSV and other viruses in children under 2 years of age: clinical presentation, medical treatment, and family impact (Germany, 11\/2022-10\/2024)","volume":"161","author":"Hecker","year":"2025","journal-title":"Int J Infect Dis"},{"key":"2026061319190240100_ref9","doi-asserted-by":"publisher","first-page":"e488","DOI":"10.1097\/INF.0000000000004105","article-title":"Respiratory syncytial virus in outpatient children with bronchiolitis: continuous virus circulation during the nonepidemic period","volume":"42","author":"Rybak","year":"2023","journal-title":"Pediatr Infect Dis J"},{"key":"2026061319190240100_ref10","doi-asserted-by":"publisher","first-page":"2425","DOI":"10.1056\/NEJMoa2309189","article-title":"Nirsevimab for prevention of hospitalizations due to RSV in infants","volume":"389","author":"Drysdale","year":"2023","journal-title":"N Engl J Med"},{"key":"2026061319190240100_ref11","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1056\/NEJMoa2216480","article-title":"Bivalent prefusion F vaccine in pregnancy to prevent RSV illness in infants","volume":"388","author":"Kampmann","year":"2023","journal-title":"N Engl J Med"},{"key":"2026061319190240100_ref12","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1056\/NEJMoa2314885","article-title":"Nirsevimab and hospitalization for RSV bronchiolitis","volume":"391","author":"Assad","year":"2024","journal-title":"N Engl J Med"},{"key":"2026061319190240100_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2024.101007","article-title":"Effectiveness of nirsevimab against RSV-bronchiolitis in paediatric ambulatory care: a test-negative case-control study","author":"Lassoued","journal-title":"Lancet Reg Health Eur"},{"key":"2026061319190240100_ref14","doi-asserted-by":"publisher","first-page":"e2540720","DOI":"10.1001\/jamanetworkopen.2025.40720","article-title":"Nirsevimab treatment of RSV bronchiolitis in pediatric emergency departments","volume":"8","author":"Lenglart","year":"2025","journal-title":"JAMA Netw Open"},{"key":"2026061319190240100_ref15","doi-asserted-by":"publisher","first-page":"29","DOI":"10.2807\/1560-7917.ES.2024.29.6.2400046","article-title":"Early estimates of nirsevimab immunoprophylaxis effectiveness against hospital admission for respiratory syncytial virus lower respiratory tract infections in infants, Spain, October 2023 to January 2024","volume":"29","author":"L\u00f3pez-Lacort","journal-title":"Eurosurveillance"},{"key":"2026061319190240100_ref16","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1038\/s41591-024-03431-7","article-title":"Impact of RSVpreF vaccination on reducing the burden of respiratory syncytial virus in infants and older adults","volume":"31","author":"Du","year":"2025","journal-title":"Nat Med"},{"key":"2026061319190240100_ref17","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1001\/jamapediatrics.2025.5778","article-title":"Effectiveness and impact of maternal RSV immunization and nirsevimab on medically attended RSV in US children","volume":"180","author":"Moline","year":"2025","journal-title":"JAMA Pediatr"},{"key":"2026061319190240100_ref18","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.24082","article-title":"Nirsevimab vs RSVpreF vaccine for respiratory syncytial virus\u2013related hospitalization in Newborns","volume":"335","author":"Jabagi","year":"2025","journal-title":"JAMA"},{"key":"2026061319190240100_ref19","doi-asserted-by":"publisher","first-page":"e511","DOI":"10.1097\/INF.0000000000003270","article-title":"Delayed bronchiolitis epidemic in French primary care setting driven by respiratory syncytial virus: preliminary data from the Oursyn study, march 2021","volume":"40","author":"Rybak","year":"2021","journal-title":"Pediatr Infect Dis J"},{"key":"2026061319190240100_ref20","volume-title":"Bulletin Infections Respiratoires aigu\u00ebs\u2014Semaine 12\u2014Edition Nationale","author":"Sant\u00e9 Publique France","year":"2024"},{"key":"2026061319190240100_ref21","volume-title":"Bulletin Infections Respiratoires aigu\u00ebs. Edition Nationale. Semaine 5 (27 Janvier au 2 f\u00e9vrier 2025)","author":"Semaille","year":"2025"},{"key":"2026061319190240100_ref22","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/S2213-2600(24)00367-9","article-title":"Burden of RSV infections among young children in primary care: a prospective cohort study in five European countries (2021\u201323)","volume":"13","author":"Hak","year":"2025","journal-title":"Lancet Respir Med"},{"key":"2026061319190240100_ref23","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1007\/s40121-024-00989-0","article-title":"The multifaceted burden of respiratory syncytial virus (RSV) infections in young children on the family: a European study","volume":"13","author":"Trautmannsberger","year":"2024","journal-title":"Infect Dis Ther"},{"key":"2026061319190240100_ref24","doi-asserted-by":"publisher","first-page":"e124","DOI":"10.1097\/INF.0000000000004630","article-title":"Impact of nirsevimab on respiratory syncytial virus bronchiolitis in hospitalized infants: a real-world study","volume":"44","author":"Jeziorski","year":"2025","journal-title":"Pediatr Infect Dis J"},{"key":"2026061319190240100_ref25","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1016\/S1473-3099(25)00233-6","article-title":"Effectiveness and impact of nirsevimab in Chile during the first season of a national immunisation strategy against RSV (NIRSE-CL): a retrospective observational study","volume":"25","author":"Torres","year":"2025","journal-title":"Lancet Infect Dis"},{"key":"2026061319190240100_ref26","doi-asserted-by":"publisher","first-page":"104769","DOI":"10.1016\/j.idnow.2023.104769","article-title":"Diagnostic accuracy of a rapid antigen triple test (SARS-CoV-2, respiratory syncytial virus, and influenza) using anterior nasal swabs versus multiplex RT-PCR in children in an emergency department","volume":"53","author":"Ferrani","year":"2023","journal-title":"Infect Dis Now"},{"key":"2026061319190240100_ref27","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1097\/INF.0000000000005115","article-title":"Performance of a rapid triple test, SARS-CoV-2\u2009+\u2009influenza a\/B\u2009+\u2009respiratory syncytial virus compared with RT-PCR for ambulatory pediatric patients","volume":"45","author":"Cohen","year":"2025","journal-title":"Pediatr Infect Dis J"}],"container-title":["Journal of the Pediatric Infectious Diseases Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jpids\/advance-article-pdf\/doi\/10.1093\/jpids\/piag035\/68328683\/piag035.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpids\/article-pdf\/15\/6\/piag035\/68328683\/piag035.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpids\/article-pdf\/15\/6\/piag035\/68328683\/piag035.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T16:06:39Z","timestamp":1781453199000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpids\/article\/doi\/10.1093\/jpids\/piag035\/8686409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,18]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6,12]]}},"URL":"https:\/\/doi.org\/10.1093\/jpids\/piag035","relation":{},"ISSN":["2048-7207"],"issn-type":[{"value":"2048-7207","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,6]]},"published":{"date-parts":[[2026,5,18]]},"article-number":"piag035"}}