{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T23:54:40Z","timestamp":1781826880903,"version":"3.54.5"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T00:00:00Z","timestamp":1779494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences of the NIH","doi-asserted-by":"crossref","award":["UL1 TR002319"],"award-info":[{"award-number":["UL1 TR002319"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Institutes of Mental Health of the U.S. National Institutes of Health","award":["NIH, R34MH115769"],"award-info":[{"award-number":["NIH, R34MH115769"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Viral suppression (VS) amongst children living with HIV (CLHIV) remains poor and several factors may affect sustained VS (SVS) over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a secondary analysis of data from a randomized control trial among CLHIV in western Kenya assessing individual, caregiver, and household factors associated with SVS, defined as viral load &amp;lt;1000 copies\/mL throughout the study period of 12\u00a0months. We used multivariate logistic regression analysis, adjusting for additional covariates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 668 CLHIV were included, median age of 9\u00a0years (interquartile range (IQR) 7-12) and time on antiretroviral treatment (ART) 6\u00a0years (IQR 3-8). Using a viral load (VL) cut off of 1000 copies\/mL, the factors associated with lower odds of SVS were (1) self-reported child\u2019s poor ART adherence [adjusted odds ratio (AOR) 0.43; 95% CI, 0.27, 0.69]; (2) being on protease inhibitor-containing regimen [AOR 0.49 (0.31, 0.79)]; (3) spending less than 30\u00a0minutes travelling to the facility [AOR 0.59 (0.37, 0.95)] and (4) having more VL results available for analysis [AOR 0.80 (0.71, 0.90)]. At VL cut off of 200 and 50 copies\/mL, being on PI containing regimen and travel duration to clinic were no longer associated with SVS. However, at VL cut off of 50 copies\/mL, additional factors associated with lower odds of SVS were less than 2\u00a0years on ART [AOR 0.29 (0.14, 0.64)] and caregiver depression [AOR 0.61 (0.41, 0.91)].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This analysis found that adherence on ART, years on ART, ART \u201canchor\u201d drug, caregiver depression, travel duration to the health facility and number of VL assays were associated with SVS among CLHIV. Interventions to improve health outcomes for CLHIV should consider and address all relevant risk factors for viral non-suppression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jpids\/piag038","type":"journal-article","created":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T11:42:32Z","timestamp":1779536552000},"source":"Crossref","is-referenced-by-count":0,"title":["Predictors of Sustained Viral Suppression among Children Living with HIV in Kenya: Secondary Analysis of Data from a Randomized Control Study"],"prefix":"10.1093","volume":"15","author":[{"given":"Patrick","family":"Oyaro","sequence":"first","affiliation":[{"name":"Lvct Health , Nairobi ,","place":["Kenya"]},{"name":"Health Innovations Kenya , Kisumu ,","place":["Kenya"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garoma W","family":"Basha","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington , Seattle, WA ,","place":["United 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