{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:52:28Z","timestamp":1791985948717,"version":"4.4.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Pediatric data on ceftazidime-avibactam (CAZ-AVI) for carbapenem-resistant Enterobacterales (CRE) infections remain limited, particularly in Latin America, where KPC-producing organisms are endemic. We describe the clinical characteristics, microbiological profile, and outcomes of children with CRE infections treated with CAZ-AVI at a tertiary referral center in Colombia.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We conducted a retrospective cohort study of children younger than 18 years with clinically significant CRE infections treated with CAZ-AVI between January 2018 and June 2025. Clinical, microbiological, treatment, and outcome data were collected. The primary outcome was clinical response at the end of therapy.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Forty-three patients were included (median age, 11 years [IQR, 6\u201315]); 25 patients (58%) were immunocompromised, 29 (67%) required PICU admission, and 16 (37%) presented with septic shock. Klebsiella pneumoniae was the predominant pathogen (33 patients, 77%), and KPC was the most common carbapenemase detected (39 patients, 91%). Clinical improvement within 72 hours occurred in 40 patients (93%), with a median time to response of 2 days (IQR, 2\u20133). Overall, 40 patients (93%) achieved clinical cure. The estimated 30-day survival probability was 95.3% (95% CI, 88.8\u2013100), recurrence occurred in 3 patients (7%), and no treatment-related adverse events were documented.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n In this real-world pediatric cohort from a KPC-endemic setting, CAZ-AVI was associated with favorable clinical outcomes and good tolerability. These findings support its role as an important therapeutic option for pediatric CRE infections and underscore the importance of mechanism-guided antimicrobial management.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/jpids\/piag109","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:37:40Z","timestamp":1791891460000},"source":"Crossref","is-referenced-by-count":0,"title":["Real-World Use of Ceftazidime\u2013Avibactam for Carbapenem-Resistant Enterobacterales Infections in Children: A 7-Year Cohort From a Latin American Referral Center"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8417-9420","authenticated-orcid":false,"given":"Mar\u00eda Gabriela Novoa","family":"Villada","sequence":"first","affiliation":[{"name":"Pediatric Residency Program, School of Health Sciences, Universidad Pontificia Bolivariana , Medell\u00edn ,","place":["Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Restrepo","family":"Gouzy","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infectious Diseases, Hospital Pablo Tob\u00f3n Uribe , Medell\u00edn ,","place":["Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Trujillo-Valencia","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infectious Diseases, Hospital Pablo Tob\u00f3n Uribe , Medell\u00edn ,","place":["Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria","family":"Viana","sequence":"additional","affiliation":[{"name":"School of Health Sciences, Universidad Pontificia Bolivariana , Medell\u00edn ,","place":["Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela Arbel\u00e1ez","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"School of Health Sciences, Universidad Pontificia Bolivariana , Medell\u00edn ,","place":["Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libia Maria Rodr\u00edguez","family":"Padilla","sequence":"additional","affiliation":[{"name":"Full Professor, School of Health Sciences, Universidad Pontificia Bolivariana , Medell\u00edn ,","place":["Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0525-9276","authenticated-orcid":false,"given":"Alejandro Diaz","family":"Diaz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infectious Diseases, Hospital Pablo Tob\u00f3n Uribe , Medell\u00edn ,","place":["Colombia"]},{"name":"Department of Pediatric Infectious Diseases, Hospital General de Medell\u00edn , Medell\u00edn ,","place":["Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,14]]},"container-title":["Journal of the Pediatric Infectious Diseases Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jpids\/advance-article-pdf\/doi\/10.1093\/jpids\/piag109\/71946590\/piag109.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpids\/advance-article-pdf\/doi\/10.1093\/jpids\/piag109\/71946590\/piag109.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:29:32Z","timestamp":1791984572000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpids\/advance-article\/doi\/10.1093\/jpids\/piag109\/8916442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,14]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/jpids\/piag109","relation":{},"ISSN":["2048-7207"],"issn-type":[{"value":"2048-7207","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,14]]},"article-number":"piag109"}}