{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T23:13:58Z","timestamp":1789514038952,"version":"build-2803163510"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1093\/jpids\/piu010","type":"journal-article","created":{"date-parts":[[2014,3,21]],"date-time":"2014-03-21T00:53:48Z","timestamp":1395363228000},"page":"320-328","source":"Crossref","is-referenced-by-count":121,"title":["Extended-Spectrum \u03b2-Lactamase\u2013Producing and Third-Generation Cephalosporin-Resistant Enterobacteriaceae in Children: Trends in the United States, 1999\u20132011"],"prefix":"10.1093","volume":"3","author":[{"given":"Latania K.","family":"Logan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolay P.","family":"Braykov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Weinstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramanan","family":"Laxminarayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,3,19]]},"reference":[{"key":"key\n\t\t\t\t20170523182758_PIU010C1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/BF01641355","article-title":"Transferable resistance to cefotaxime, cefoxitin, cefamandole and cefuroxime in clinical isolates of Klebsiella pneumoniae and Serratia marcescens","volume":"11","author":"Knothe","year":"1983","journal-title":"Infection"},{"key":"key\n\t\t\t\t20170523182758_PIU010C2","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1128\/AAC.01009-09","article-title":"Updated functional classification of beta-lactamases","volume":"54","author":"Bush","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20170523182758_PIU010C3","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1056\/NEJMra041359","article-title":"The new \u03b2-lactamases","volume":"352","author":"Jacoby","year":"2005","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170523182758_PIU010C4","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1146\/annurev-micro-090110-102911","article-title":"Epidemiological expansion, structural studies, and clinical challenges of new \u03b2-lactamases from gram-negative bacteria","volume":"65","author":"Bush","year":"2011","journal-title":"Annu Rev Microbiol"},{"key":"key\n\t\t\t\t20170523182758_PIU010C5","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1098\/rstb.1980.0049","article-title":"The structure of beta\u2013lactamases","volume":"289","author":"Ambler","year":"1980","journal-title":"Philosoph Transact R Soc Biol Sci"},{"key":"key\n\t\t\t\t20170523182758_PIU010C6","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1128\/JCM.06852-11","article-title":"Current trends in culture-based and molecular detection of ESBL-harboring and carbapenem-resistant Enterobacteriaceae","volume":"50","author":"Gazin","year":"2012","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t20170523182758_PIU010C7","doi-asserted-by":"crossref","first-page":"4065","DOI":"10.1128\/JCM.37.12.4065-4070.1999","article-title":"Detection and reporting of organisms producing extended-spectrum \u00df-lactamases: Survey of laboratories in Connecticut","volume":"37","author":"Tenover","year":"1999","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t20170523182758_PIU010C8","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1128\/JCM.00219-10","article-title":"Extended-spectrum-\u00df-lactamase, AmpC, and carbapenemase issues","volume":"48","author":"Thomson","year":"2010","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t20170523182758_PIU010C9","article-title":"Antibiotic resistance threats in the United States, 2013","author":"Centers for Disease Control and Prevention (CDC)"},{"key":"key\n\t\t\t\t20170523182758_PIU010C10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1086\/668770","article-title":"Antimicrobial-resistant pathogens associated with healthcare-associated infections: Summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2009\u20132010","volume":"34","author":"Sievert","year":"2013","journal-title":"Infect Control Hosp Epidemiol"},{"key":"key\n\t\t\t\t20170523182758_PIU010C11","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1086\/502253","article-title":"Attributable costs and length of stay of an extended-spectrum beta-lactamase-producing Klebsiella pneumoniae outbreak in a neonatal intensive care unit","volume":"24","author":"Stone","year":"2003","journal-title":"Infect Control Hosp Epidemiol"},{"key":"key\n\t\t\t\t20170523182758_PIU010C12","doi-asserted-by":"crossref","DOI":"10.1086\/500663","article-title":"Extended-spectrum \u03b2-lactamases and clinical outcomes: Current data","volume":"42","author":"Ramphal","year":"2006","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20170523182758_PIU010C13","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1128\/CMR.18.4.657-686.2005","article-title":"Extended-spectrum \u03b2-lactamases: A clinical update","volume":"18","author":"Paterson","year":"2005","journal-title":"Clin Microbiol Rev"},{"key":"key\n\t\t\t\t20170523182758_PIU010C14","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.ajic.2007.05.008","article-title":"Clinical and molecular epidemiology of community-onset, extended-spectrum beta-lactamase-producing Escherichia coli infections in Thailand: A case-case-control study","volume":"35","author":"Apisarnthanarak","year":"2007","journal-title":"Am J Infect Control"},{"key":"key\n\t\t\t\t20170523182758_PIU010C15","first-page":"229","article-title":"Outcome of infections with extended spectrum beta-lactamase producing organisms in children","volume":"3","author":"Jhaveri","year":"2008","journal-title":"J Pediatr Infect Dis"},{"key":"key\n\t\t\t\t20170523182758_PIU010C16","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.ajic.2008.09.019","article-title":"Extended-spectrum beta-lactamase-producing pathogens in a children's hospital: A 5-year experience","volume":"37","author":"Blaschke","year":"2009","journal-title":"Am J Infect Control"},{"key":"key\n\t\t\t\t20170523182758_PIU010C17","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1542\/peds.2004-1289","article-title":"Risk factors for and outcomes of bloodstream infection caused by extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species in children","volume":"115","author":"Zaoutis","year":"2005","journal-title":"Pediatrics"},{"key":"key\n\t\t\t\t20170523182758_PIU010C18","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1086\/669523","article-title":"Trends in resistance to carbapenems and third-generation cephalosporins among clinical isolates of Klebsiella pneumoniae in the United States, 1999\u20132010","volume":"34","author":"Braykov","year":"2013","journal-title":"Infect Control Hosp Epidemiol"},{"key":"key\n\t\t\t\t20170523182758_PIU010C19","doi-asserted-by":"crossref","DOI":"10.1186\/1476-0711-3-3","article-title":"Prevalence of antimicrobial resistance in bacteria isolated from central nervous system specimens as reported by U.S. hospital laboratories from 2000 to 2002","volume":"3","author":"Jones","year":"2004","journal-title":"Ann Clin Microbiol Antimicrob"},{"key":"key\n\t\t\t\t20170523182758_PIU010C20","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.3201\/eid1512.081341","article-title":"Community-associated methicillin-resistant Staphylococcus aureus in outpatients, United States, 1999\u20132006","volume":"15","author":"Klein","year":"2009","journal-title":"Emerg Infect Dis"},{"key":"key\n\t\t\t\t20170523182758_PIU010C21","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1086\/520195","article-title":"Antimicrobial resistance in key bloodstream bacterial isolates: Electronic surveillance with the Surveillance Network Database\u2014USA","volume":"29","author":"Sahm","year":"1999","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20170523182758_PIU010C22","article-title":"Performance Standards for Antimicrobial Susceptibility Testing: Twentieth Informational Supplement (June 2010 Update)","author":"Clinical and Laboratory Standards Institute","year":"2010"},{"key":"key\n\t\t\t\t20170523182758_PIU010C23","first-page":"165","article-title":"Vital signs: Carbapenem-resistant Enterobacteriaceae","volume":"62","author":"Centers for Disease Control and Prevention (CDC)","year":"2013","journal-title":"MMWR Morbid Mortal Wkly Rep"},{"key":"key\n\t\t\t\t20170523182758_PIU010C24","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1086\/502045","article-title":"Extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species: Risk factors for colonization and impact of antimicrobial formulary interventions on colonization prevalence","volume":"23","author":"Bisson","year":"2002","journal-title":"Infect Control Hosp Epidemiol"},{"key":"key\n\t\t\t\t20170523182758_PIU010C25","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jhin.2007.10.011","article-title":"Evaluation of risk factors for the acquisition of bloodstream infections with extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species in the intensive care unit; antibiotic management and clinical outcome","volume":"68","author":"Cordery","year":"2008","journal-title":"J Hosp Infect"},{"key":"key\n\t\t\t\t20170523182758_PIU010C26","doi-asserted-by":"crossref","first-page":"4010","DOI":"10.1128\/AAC.02516-12","article-title":"Epidemiology and risk factors for isolation of Escherichia coli producing CTX-M-type extended-spectrum \u00df-lactamase in a large U.S. medical center","volume":"57","author":"Hayakawa","year":"2013","journal-title":"Antimicrob Agent Chemother"},{"key":"key\n\t\t\t\t20170523182758_PIU010C27","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.resmic.2004.02.009","article-title":"Characteristics, epidemiology and clinical importance of emerging strains of Gram-negative bacilli producing extended-spectrum \u00df-lactamases","volume":"155","author":"Shah","year":"2004","journal-title":"Res Microbiol"},{"key":"key\n\t\t\t\t20170523182758_PIU010C28","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0163-4453(03)00096-3","article-title":"Extended-spectrum \u00df-lactamases: Implications for the clinical microbiology laboratory, therapy, and infection control","volume":"47","author":"St\u00fcrenburg","year":"2003","journal-title":"J Infect"},{"key":"key\n\t\t\t\t20170523182758_PIU010C29","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1093\/jpids\/piu011","article-title":"for the CDC Epicenters Prevention Program. Extended-spectrum \u00df-lactamase\u2013producing Enterobacteriaceae infections in children: A two-center case\u2013case\u2013control study of risk factors and outcomes in Chicago, Illinois","volume":"3","author":"Logan","year":"2014","journal-title":"J Pediatr Infect Dis"},{"key":"key\n\t\t\t\t20170523182758_PIU010C30","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1093\/cid\/cis543","article-title":"Carbapenem-resistant Enterobacteriaceae: An emerging problem in children","volume":"55","author":"Logan","year":"2012","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20170523182758_PIU010C31","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1093\/jac\/dkq237","article-title":"Fosfomycin versus other antibiotics for the treatment of cystitis: A meta-analysis of randomized controlled trials","volume":"65","author":"Falagas","year":"2010","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20170523182758_PIU010C32","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1093\/cid\/cis942","article-title":"Community-associated extended-spectrum \u00df-lactamase\u2013producing Escherichia coli infection in the United States","volume":"56","author":"Doi","year":"2013","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20170523182758_PIU010C33","doi-asserted-by":"crossref","first-page":"4765","DOI":"10.1128\/AAC.00666-12","article-title":"Prevalence and molecular characterization of extended-spectrum-\u00df-lactamase-producing Enterobacteriaceae in a pediatric patient population","volume":"56","author":"Chandramohan","year":"2012","journal-title":"Antimicrob Agent Chemother"},{"key":"key\n\t\t\t\t20170523182758_PIU010C34","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.ijantimicag.2013.01.006","article-title":"Emergence of extended-spectrum \u03b2-lactam resistance among Escherichia coli at a US academic children's hospital is clonal at the sequence type level for CTX-M-15, but not for CMY-2","volume":"41","author":"Weissman","year":"2013","journal-title":"Int J Antimicrob Agents"},{"key":"key\n\t\t\t\t20170523182758_PIU010C35","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.mib.2006.08.011","article-title":"The CTX-M \u03b2-lactamase pandemic","volume":"9","author":"Cant\u00f3n","year":"2006","journal-title":"Curr Opin Microbiol"},{"key":"key\n\t\t\t\t20170523182758_PIU010C36","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1093\/cid\/cis036","article-title":"\u201cSilent\u201d dissemination of Klebsiella pneumoniae isolates bearing K. pneumoniae carbapenemase in a long-term care facility for children and young adults in Northeast Ohio","volume":"54","author":"Viau","year":"2012","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20170523182758_PIU010C37","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1086\/668783","article-title":"Anatomic sites of patient colonization and environmental contamination with Klebsiella pneumoniae carbapenemase\u2013producing Enterobacteriaceae at long-term acute care hospitals","volume":"34","author":"Thurlow","year":"2013","journal-title":"Infect Control Hosp Epidemiol"},{"key":"key\n\t\t\t\t20170523182758_PIU010C38","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1086\/668435","article-title":"Transfer from high-acuity long-term care facilities is associated with carriage of Klebsiella pneumoniae carbapenemase\u2013producing Enterobacteriaceae: A multihospital study","volume":"33","author":"Prabaker","year":"2012","journal-title":"Infect Control Hosp Epidemiol"},{"key":"key\n\t\t\t\t20170523182758_PIU010C39","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1093\/jac\/dks502","article-title":"Long-term faecal carriage in infants and intra-household transmission of CTX-M-15-producing Klebsiella pneumoniae following a nosocomial outbreak","volume":"68","author":"L\u00f6hr","year":"2013","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20170523182758_PIU010C40","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.diagmicrobio.2011.07.013","article-title":"Prevalence of beta-lactam nonsusceptible Gram-negative bacilli and use and interpretation of current susceptibility breakpoints: A survey of infectious disease physicians","volume":"71","author":"Kallen","year":"2011","journal-title":"Diag Microbiol Infect Dis"},{"key":"key\n\t\t\t\t20170523182758_PIU010C41","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1086\/591861","article-title":"NHSN annual update: Antimicrobial-resistant pathogens associated with healthcare-associated infections: Annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006\u20132007","volume":"29","author":"Hidron","year":"2008","journal-title":"Infect Control Hosp Epidemiol"},{"key":"key\n\t\t\t\t20170523182758_PIU010C42","first-page":"78","article-title":"Antimicrobial resistance trends and outbreak frequency in United States hospitals. Clin Infect Dis","volume":"38","author":"Diekema","year":"2004"},{"key":"key\n\t\t\t\t20170523182758_PIU010C43","doi-asserted-by":"crossref","DOI":"10.1186\/1476-0711-3-7","article-title":"Prevalence and antimicrobial susceptibilities of bacteria isolated from blood cultures of hospitalized patients in the United States in 2002","volume":"3","author":"Karlowsky","year":"2004","journal-title":"Ann Clin Microbiol Antimicrob"}],"container-title":["Journal of the Pediatric Infectious Diseases Society"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jpids\/article-pdf\/3\/4\/320\/17487920\/piu010.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T03:41:57Z","timestamp":1746157317000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpids\/article-lookup\/doi\/10.1093\/jpids\/piu010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,19]]},"references-count":43,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,3,19]]},"published-print":{"date-parts":[[2014,12]]}},"URL":"https:\/\/doi.org\/10.1093\/jpids\/piu010","relation":{},"ISSN":["2048-7207","2048-7193"],"issn-type":[{"value":"2048-7207","type":"electronic"},{"value":"2048-7193","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3,19]]}}}