{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T05:27:09Z","timestamp":1793165229982,"version":"4.5.0"},"reference-count":138,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T00:00:00Z","timestamp":1560124800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mucormycosis is a severe infection that affects a variety of patients, including immunocompromised children and neonates. Given improved survival rates from advances in the treatment of malignancies, the population at risk for mucormycosis is increasing. We conducted a systematic review of cases of mucormycosis in children in the English-language literature reported between August 2008 and June 2017 and analyzed the clinical characteristics, diagnosis, management, and outcome of those infections. The most common underlying diagnoses included neutropenia (41%), hematologic malignancy (39%), prematurity (13%), and hematopoietic stem cell transplant (11%). Sinus disease (28%) and disseminated disease (24%) were the most common presentations. Rhizopus spp were the most common organisms isolated (22%). Amphotericin B remains the backbone of treatment and was prescribed in 86% of these cases. The resulting mortality rate remains high (32%). We provide here the results of a literature review of mucormycosis in children, including its epidemiology and clinical manifestations, and describe current advances in its diagnosis and treatment.<\/jats:p>","DOI":"10.1093\/jpids\/piz007","type":"journal-article","created":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T15:13:14Z","timestamp":1559833994000},"page":"342-350","source":"Crossref","is-referenced-by-count":36,"title":["Pediatric Mucormycosis: A 10-Year Systematic Review of Reported Cases and Review of the Literature"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7959-1445","authenticated-orcid":false,"given":"William R","family":"Otto","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Infectious Diseases, Children\u2019s Hospital of Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara A","family":"Pahud","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Infectious Diseases, Children\u2019s Mercy, Kansas City, Missouri"},{"name":"Department of Pediatrics, University of Missouri\u2013Kansas City School of Medicine, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dwight E","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Infectious Diseases, Children\u2019s Mercy, Kansas City, Missouri"},{"name":"Department of Pediatrics, University of Missouri\u2013Kansas City School of Medicine, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,6,10]]},"reference":[{"key":"2019100522584233800_CIT0001","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1093\/cid\/cir864","article-title":"Taxonomy of fungi causing mucormycosis and entomophthoramycosis (zygomycosis) and nomenclature of the disease: 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