{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T04:54:33Z","timestamp":1772859273288,"version":"3.50.1"},"reference-count":14,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T00:00:00Z","timestamp":1560211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Little information on the efficacy and pharmacokinetics of letermovir among immunocompromised children is currently available. We describe here the use of letermovir in a 2-year-old immunocompromised child with ganciclovir-resistant cytomegalovirus disease who required extracorporeal membrane oxygenation. Detailed information on therapeutic-drug-monitoring measures and dosage adjustments for letermovir is provided.<\/jats:p>","DOI":"10.1093\/jpids\/piz033","type":"journal-article","created":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T16:14:07Z","timestamp":1557159247000},"source":"Crossref","is-referenced-by-count":12,"title":["Compassionate Use of Letermovir in a 2-Year-Old Immunocompromised Child With Resistant Cytomegalovirus Disease"],"prefix":"10.1093","author":[{"given":"Maria","family":"P\u00e9rez Mar\u00edn","sequence":"first","affiliation":[{"name":"Pediatric Intensive Care Unit, University Hospital Center and University of Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent Arthur","family":"Decosterd","sequence":"additional","affiliation":[{"name":"Service of Clinical Pharmacology, University Hospital Center and University of Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Andre","sequence":"additional","affiliation":[{"name":"Service of Clinical Pharmacology, University Hospital Center and University of Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Buclin","sequence":"additional","affiliation":[{"name":"Service of Clinical Pharmacology, University Hospital Center and University of Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Mercier","sequence":"additional","affiliation":[{"name":"Service of Clinical Pharmacology, University Hospital Center and University of Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Murray","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Diseases and Vaccinology Unit, Woman-Mother-Child Department, University Hospital Center and University of Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattia","family":"Rizzi","sequence":"additional","affiliation":[{"name":"Pediatric Hematology-Oncology Unit, University Hospital Center and University of Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Meylan","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, Department of Laboratories, University Hospital Center and University of Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katia","family":"Jaton-Ogay","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, Department of Laboratories, University Hospital Center and University of Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onya","family":"Opota","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, Department of Laboratories, University Hospital Center and University of Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carole","family":"Gengler","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Hospital Center and University of Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-H\u00e9l\u00e8ne","family":"Perez","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, University Hospital Center and University of Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Natterer","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, University Hospital Center and University of Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra Andrea","family":"Asner","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Diseases and Vaccinology Unit, Woman-Mother-Child Department, University Hospital Center and University of Lausanne, Switzerland"},{"name":"Infectious Diseases Service, Department of Medicine, University Hospital Center and University of Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,6,11]]},"reference":[{"key":"2019062907023450200_CIT0001","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.ijantimicag.2010.11.033","article-title":"Ganciclovir treatment in children: evidence of subtherapeutic levels","volume":"37","author":"Luck","year":"2011","journal-title":"Int J Antimicrob Agents"},{"key":"2019062907023450200_CIT0002","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1046\/j.1469-0691.2000.00014.x","article-title":"Monitoring plasma levels of ganciclovir in AIDS patients receiving oral ganciclovir as maintenance therapy for CMV retinitis","volume":"6","author":"Piketty","year":"2000","journal-title":"Clin Microbiol Infect"},{"key":"2019062907023450200_CIT0003","author":"US Food and Drug Administration"},{"key":"2019062907023450200_CIT0004","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/cts.12483","article-title":"Intravenous hydroxypropyl \u03b2-cyclodextrin formulation of letermovir: a phase I, randomized, single-ascending, and multiple-dose trial","volume":"10","author":"Erb-Zohar","year":"2017","journal-title":"Clin Transl Sci"},{"key":"2019062907023450200_CIT0005","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1097\/00007890-200207270-00014","article-title":"Determinants of protracted cytomegalovirus infection in solid-organ transplant patients","volume":"74","author":"Muheim","year":"2002","journal-title":"Transplantation"},{"key":"2019062907023450200_CIT0006","doi-asserted-by":"crossref","first-page":"403","DOI":"10.2217\/fmb.15.152","article-title":"Ten years of R&D and full automation in molecular 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study","volume":"27","author":"Stoelben","year":"2014","journal-title":"Transpl Int"},{"key":"2019062907023450200_CIT0010","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1111\/j.1600-6143.2011.03530.x","article-title":"First report of successful treatment of multidrug-resistant cytomegalovirus disease with the novel anti-CMV compound AIC246","volume":"11","author":"Kaul","year":"2011","journal-title":"Am J Transplant"},{"key":"2019062907023450200_CIT0011","unstructured":"Prohn\n              M\n            , ZhangD, KerbuschT, et al\n          Nonlinear pharmacokinetics of letermovir in phase 1 suggest a role of induction. In: American Conference on Pharmacometrics, ACoP6; Poster W-068. Available at: https:\/\/www.go-acop.org\/assets\/Legacy_ACOPs\/ACoP6\/Poster_abstracts\/w-68.pdf. Accessed April 12, 2018."},{"key":"2019062907023450200_CIT0012","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1124\/dmd.115.069252","article-title":"Expression patterns of organic anion transporting polypeptides 1B1 and 1B3 protein in human pediatric liver","volume":"44","author":"Thomson","year":"2016","journal-title":"Drug Metab Dispos"},{"key":"2019062907023450200_CIT0013","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/s13054-015-0891-z","article-title":"Protein-bound drugs are prone to sequestration in the extracorporeal membrane oxygenation circuit: results from an ex vivo study","volume":"19","author":"Shekar","year":"2015","journal-title":"Crit Care"},{"key":"2019062907023450200_CIT0014","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1016\/j.clinthera.2016.07.169","article-title":"Pharmacokinetics and dosing of anti-infective drugs in patients on extracorporeal membrane oxygenation: a review of the current literature","volume":"38","author":"Sherwin","year":"2016","journal-title":"Clin Ther"}],"container-title":["Journal of the Pediatric Infectious Diseases Society"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jpids\/advance-article-pdf\/doi\/10.1093\/jpids\/piz033\/28884823\/piz033.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"}],"deposited":{"date-parts":[[2019,6,29]],"date-time":"2019-06-29T11:02:44Z","timestamp":1561806164000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpids\/advance-article\/doi\/10.1093\/jpids\/piz033\/5513534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,11]]},"references-count":14,"URL":"https:\/\/doi.org\/10.1093\/jpids\/piz033","relation":{},"ISSN":["2048-7207"],"issn-type":[{"value":"2048-7207","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,11]]},"article-number":"piz033"}}