{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T01:44:41Z","timestamp":1768009481793,"version":"3.49.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T00:00:00Z","timestamp":1564531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32-AI007062-40"],"award-info":[{"award-number":["T32-AI007062-40"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["T32-CA057726-26"],"award-info":[{"award-number":["T32-CA057726-26"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We present here the first published use of letermovir for the treatment of resistant cytomegalovirus (CMV) in a pediatric patient. A 14-year-old girl underwent a double unrelated umbilical cord blood transplantation to treat her sickle cell disease (hemoglobin SS) and developed ganciclovir-resistant CMV DNAemia with end-organ involvement that was treated successfully with a combination of foscarnet and letermovir. After she was transitioned to letermovir monotherapy for secondary prophylaxis, she developed recurrent DNAemia with laboratory-confirmed ganciclovir, foscarnet, and letermovir resistance.<\/jats:p>","DOI":"10.1093\/jpids\/piz050","type":"journal-article","created":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T21:29:42Z","timestamp":1561066182000},"page":"486-489","source":"Crossref","is-referenced-by-count":30,"title":["Use of Letermovir for Salvage Therapy for Resistant Cytomegalovirus in a Pediatric Hematopoietic Stem Cell Transplant Recipient"],"prefix":"10.1093","volume":"9","author":[{"given":"Jacob T","family":"Kilgore","sequence":"first","affiliation":[{"name":"Division of Pediatric Infectious Diseases, Duke University, Durham, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"Bradford","family":"Becken","sequence":"additional","affiliation":[{"name":"Division of Pediatric Infectious Diseases, Duke University, Durham, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew G","family":"Varga","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health and the Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhag","family":"Parikh","sequence":"additional","affiliation":[{"name":"Pediatric Bone Marrow Transplant Program, Duke University, Durham, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinod","family":"Prasad","sequence":"additional","affiliation":[{"name":"Pediatric Bone Marrow Transplant Program, Duke University, Durham, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debra","family":"Lugo","sequence":"additional","affiliation":[{"name":"Division of Pediatric Infectious Diseases, Duke University, Durham, North Carolina"},{"name":"Pediatric Immunocompromised Host Program, Duke University, Durham, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeh-Chung","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Pediatric Infectious Diseases, Duke University, Durham, North Carolina"},{"name":"Pediatric Immunocompromised Host Program, Duke University, Durham, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,7,31]]},"reference":[{"key":"2020091707141856400_CIT0001","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/bmt.2013.164","article-title":"Survey of CMV management in pediatric allogeneic HSCT programs, on behalf of the inborn errors, infectious diseases and pediatric diseases working parties of EBMT","volume":"49","author":"Bontant","year":"2014","journal-title":"Bone Marrow Transplant"},{"key":"2020091707141856400_CIT0002","doi-asserted-by":"crossref","first-page":"507","DOI":"10.3389\/fimmu.2016.00507","article-title":"Immune reconstitution after allogeneic hematopoietic stem cell transplantation","volume":"7","author":"Ogonek","year":"2016","journal-title":"Front Immunol"},{"key":"2020091707141856400_CIT0003","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/s40506-014-0021-5","article-title":"Cytomegalovirus treatment","volume":"6","author":"Tan","year":"2014","journal-title":"Curr Treat Options Infect Dis"},{"key":"2020091707141856400_CIT0004","doi-asserted-by":"crossref","first-page":"8","DOI":"10.2174\/157489112799829765","article-title":"Current and emerging antivirals for the treatment of cytomegalovirus (CMV) retinitis: an update on recent patents","volume":"7","author":"Vadlapudi","year":"2012","journal-title":"Recent Pat Antiinfect Drug Discov"},{"key":"2020091707141856400_CIT0005","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1182\/blood.V97.2.388","article-title":"Cidofovir for cytomegalovirus infection and disease in allogeneic stem cell transplant recipients. The Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation","volume":"97","author":"Ljungman","year":"2001","journal-title":"Blood"},{"key":"2020091707141856400_CIT0006","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1056\/NEJMoa1706640","article-title":"Letermovir prophylaxis for cytomegalovirus in hematopoietic-cell transplantation","volume":"377","author":"Marty","year":"2017","journal-title":"N Engl J Med"},{"key":"2020091707141856400_CIT0007","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1128\/AAC.34.2.373","article-title":"Synergistic effect of ganciclovir and foscarnet on cytomegalovirus replication in vitro","volume":"34","author":"Manischewitz","year":"1990","journal-title":"Antimicrob Agents Chemother"},{"key":"2020091707141856400_CIT0008","doi-asserted-by":"crossref","first-page":"6588","DOI":"10.1128\/AAC.01623-15","article-title":"Rapid in vitro evolution of human cytomegalovirus UL56 mutations that confer letermovir resistance","volume":"59","author":"Chou","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"2020091707141856400_CIT0009","doi-asserted-by":"crossref","first-page":"10884","DOI":"10.1128\/JVI.05265-11","article-title":"The novel anticytomegalovirus compound AIC246 (letermovir) inhibits human cytomegalovirus replication through a specific antiviral mechanism that involves the viral terminase","volume":"85","author":"Goldner","year":"2011","journal-title":"J Virol"},{"key":"2020091707141856400_CIT0010","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1182\/bloodadvances.2018016493","article-title":"Antiviral prophylaxis for cytomegalovirus infection in allogeneic hematopoietic cell transplantation","volume":"2","author":"Chen","year":"2018","journal-title":"Blood Adv"}],"container-title":["Journal of the Pediatric Infectious Diseases Society"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jpids\/article-pdf\/9\/4\/486\/33761823\/piz050.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jpids\/article-pdf\/9\/4\/486\/33761823\/piz050.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T11:14:37Z","timestamp":1600341277000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpids\/article\/9\/4\/486\/5541615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,31]]},"references-count":10,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,7,31]]},"published-print":{"date-parts":[[2020,9,17]]}},"URL":"https:\/\/doi.org\/10.1093\/jpids\/piz050","relation":{},"ISSN":["2048-7207"],"issn-type":[{"value":"2048-7207","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,9,1]]},"published":{"date-parts":[[2019,7,31]]}}}