{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T06:16:45Z","timestamp":1779257805076,"version":"3.51.4"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T00:00:00Z","timestamp":1569283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100006967","name":"Duke Center for AIDS Research","doi-asserted-by":"crossref","award":["P30-AI064518"],"award-info":[{"award-number":["P30-AI064518"]}],"id":[{"id":"10.13039\/100006967","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23-AI135090"],"award-info":[{"award-number":["K23-AI135090"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5T32-HL007538-33"],"award-info":[{"award-number":["5T32-HL007538-33"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Maternal human immunodeficiency virus (HIV) infection is associated with lower placental transfer of antibodies specific to several childhood pathogens. Our objective for this study was to evaluate the effect of maternal HIV infection on the placental transfer of respiratory syncytial virus (RSV)-neutralizing antibodies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a cross-sectional study of mothers and their newborn infants at a tertiary hospital in Gaborone, Botswana, between March 2015 and December 2015. We measured serum RSV antibody levels by using a microneutralization assay. We used multivariable linear regression to evaluate the effect of maternal HIV infection on maternal RSV antibody levels, placental transfer of RSV antibodies, and newborn RSV antibody levels.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 316 mothers, 154 (49%) were infected with HIV. The placental transfer ratios for RSV antibodies to HIV-exposed, uninfected (HEU) and HIV-unexposed, uninfected infants were 1.02 and 1.15, respectively. The geometric mean titer (95% confidence interval) of RSV-neutralizing antibodies was 2657 (2251\u20133136) among HEU newborns and 2911 (2543\u20133331) among HIV-unexposed, uninfected newborns. In multivariable analyses, maternal HIV infection was associated with lower placental transfer of RSV antibodies (P = .02) and a lower level of RSV antibodies among newborns (P = .002). Among HEU newborns, higher birth weight (P = .004) and an undetectable maternal antenatal viral load (P = .01) were associated with more effective placental transfer of RSV antibodies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Maternal human immunodeficiency virus (HIV) infection is associated with lower mother-to-fetus transfer of serum RSV-neutralizing antibodies. HEU infants should be prioritized for preventive interventions for RSV. Maternal viral suppression through combination antiretroviral therapy has the potential to improve immunity to RSV among HIV-exposed infants.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpids\/piz056","type":"journal-article","created":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T08:31:37Z","timestamp":1569313897000},"page":"349-356","source":"Crossref","is-referenced-by-count":17,"title":["Placental Transfer of Respiratory Syncytial Virus Antibody Among HIV-Exposed, Uninfected Infants"],"prefix":"10.1093","volume":"9","author":[{"given":"Sweta M","family":"Patel","sequence":"first","affiliation":[{"name":"Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University, Durham, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabelle","family":"Jallow","sequence":"first","affiliation":[{"name":"Medical Research Council, Respiratory and Meningeal Pathogens Research Unit"},{"name":"Centre for Vaccines and Immunology, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sefelani","family":"Boiditswe","sequence":"first","affiliation":[{"name":"Botswana\u2013University of Pennsylvania Partnership, Gaborone, Botswana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shabir A","family":"Madhi","sequence":"first","affiliation":[{"name":"Medical Research Council, Respiratory and Meningeal Pathogens Research Unit"},{"name":"Department of Science and Technology\/National Research Foundation, Vaccine Preventable Diseases Research Chair, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen A","family":"Feemster","sequence":"first","affiliation":[{"name":"Global Health Center, Children\u2019s Hospital of Philadelphia, Pennsylvania"},{"name":"Division of Pediatric Infectious Diseases, Children\u2019s Hospital of Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew P","family":"Steenhoff","sequence":"first","affiliation":[{"name":"Botswana\u2013University of Pennsylvania Partnership, Gaborone, Botswana"},{"name":"Global Health Center, Children\u2019s Hospital of Philadelphia, Pennsylvania"},{"name":"Division of Pediatric Infectious Diseases, Children\u2019s Hospital of Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tonya","family":"Arscott-Mills","sequence":"first","affiliation":[{"name":"Botswana\u2013University of Pennsylvania Partnership, Gaborone, Botswana"},{"name":"Global Health Center, Children\u2019s Hospital of Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Muthoga","sequence":"first","affiliation":[{"name":"Botswana\u2013University of Pennsylvania Partnership, Gaborone, Botswana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gbolahan","family":"Ajibola","sequence":"first","affiliation":[{"name":"Botswana\u2013Harvard AIDS Institute Partnership, Gaborone, Botswana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Shapiro","sequence":"first","affiliation":[{"name":"Botswana\u2013Harvard AIDS Institute Partnership, Gaborone, Botswana"},{"name":"Harvard T. 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Chan School of Public Health, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samir S","family":"Shah","sequence":"first","affiliation":[{"name":"Divisions of Hospital Medicine and Infectious Diseases, Cincinnati Children\u2019s Hospital Medical Center, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Coleen K","family":"Cunningham","sequence":"first","affiliation":[{"name":"Division of Pediatric Infectious Diseases, Duke University, Durham, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew S","family":"Kelly","sequence":"first","affiliation":[{"name":"Botswana\u2013University of Pennsylvania Partnership, Gaborone, Botswana"},{"name":"Division of Pediatric Infectious Diseases, Duke University, Durham, North 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