{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T09:02:50Z","timestamp":1784192570265,"version":"3.55.0"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T00:00:00Z","timestamp":1569283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Neonatal toxic shock syndrome (TSS)-like exanthematous disease (NTED) is a syndrome first reported in Japan. Neonates develop systemic exanthema, thrombocytopenia, and fever usually during the first week of life. The disease is distinguished from frank TSS because affected infants are not severely ill and do not meet TSS criteria. Most infants are confirmed to be colonized with TSST-1 producing strains of S. aureus. Suggested diagnostic criteria for NTED include a skin rash with generalized macular erythema and one of the following symptoms: fever &amp;gt;38.0\u00b0C, thrombocytopenia &amp;lt;150 x103uL, or low positive C-reactive protein (1-5 mg\/dL) in the absence of another known disease process. NTED is common in Japanese NICUs, but outside Japan, only one case has been reported in France. We describe the first case of NTED reported in North America.<\/jats:p>","DOI":"10.1093\/jpids\/piz060","type":"journal-article","created":{"date-parts":[[2019,8,17]],"date-time":"2019-08-17T19:12:42Z","timestamp":1566069162000},"page":"205-206","source":"Crossref","is-referenced-by-count":6,"title":["Neonatal Toxic Shock Syndrome\u2013Like Exanthematous Disease in North America"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3389-6731","authenticated-orcid":false,"given":"Megan Culler","family":"Freeman","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Pennsylvania"},{"name":"Division of Pediatric Infectious Disease, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Department of Pathology, UPMC Children\u2019s Hospital of Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pennsylvania"},{"name":"Division of Newborn Medicine, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John V","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pennsylvania"},{"name":"Division of Pediatric Infectious Disease, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,9,24]]},"reference":[{"key":"2021032615555688900_CIT0001","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1016\/S0140-6736(97)11125-4","article-title":"Exanthematous disease induced by toxic shock syndrome toxin 1 in the early neonatal period","volume":"351","author":"Takahashi","year":"1998","journal-title":"Lancet"},{"key":"2021032615555688900_CIT0002","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1128\/JCM.41.7.3001-3006.2003","article-title":"Molecular epidemiology of methicillin-resistant Staphylococcus aureus strains causing neonatal toxic shock syndrome-like exanthematous disease in neonatal and perinatal wards","volume":"41","author":"Kikuchi","year":"2003","journal-title":"J Clin Microbiol"},{"key":"2021032615555688900_CIT0003","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.jinf.2009.06.010","article-title":"Clinical features of neonatal toxic shock syndrome-like exanthematous disease emerging in Japan","volume":"59","author":"Takahashi","year":"2009","journal-title":"J Infect"},{"key":"2021032615555688900_CIT0004","doi-asserted-by":"crossref","first-page":"4883","DOI":"10.1128\/JCM.41.10.4883-4884.2003","article-title":"Staphylococcal exanthematous disease in a newborn due to a virulent methicillin-resistant Staphylococcus aureus strain containing the TSST-1 gene in Europe: an alert for neonatologists","volume":"41","author":"van der Mee-Marquet","year":"2003","journal-title":"J Clin Microbiol"},{"key":"2021032615555688900_CIT0005","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1111\/1348-0421.12094","article-title":"Overall picture of an emerging neonatal infectious disease induced by a superantigenic exotoxin mainly produced by methicillin-resistant Staphylococcus aureus","volume":"57","author":"Takahashi","year":"2013","journal-title":"Microbiol Immunol"}],"container-title":["Journal of the Pediatric Infectious Diseases Society"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jpids\/article-pdf\/10\/2\/205\/36740119\/piz060.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jpids\/article-pdf\/10\/2\/205\/36740119\/piz060.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T15:56:08Z","timestamp":1616774168000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpids\/article\/10\/2\/205\/5573378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,24]]},"references-count":5,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,9,24]]},"published-print":{"date-parts":[[2021,3,26]]}},"URL":"https:\/\/doi.org\/10.1093\/jpids\/piz060","relation":{},"ISSN":["2048-7207"],"issn-type":[{"value":"2048-7207","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,2,1]]},"published":{"date-parts":[[2019,9,24]]}}}