{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T05:00:50Z","timestamp":1764997250207,"version":"3.37.3"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T00:00:00Z","timestamp":1570752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Hepatitis C virus (HCV) infection has a strong association with intravenous drug use (IVDU). IVDU is a growing public health concern, even in the adolescent population. To our knowledge, there are no published HCV screening studies targeting high-risk adolescents who attend drug rehabilitation centers.<\/jats:p>\n                  <jats:p>This study was designed to determine the seroprevalence of HCV infection utilizing point-of-care (POC) testing at an adolescent drug rehabilitation center and gain a preliminary understanding of the acceptance rate for HCV screening in this high-risk population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This single-center, observational study was conducted at a major drug rehabilitation center in northeast Ohio from July 2016 to June 2017. The consented adolescents who presented at the center were recruited to participate in HCV screening. The participants were administered a survey to assess their demographics and risk behavior profile followed by HCV testing utilizing a POC test.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>During the study period, 150 adolescents were admitted to the drug rehabilitation center, of whom 100 were approached and 85 agreed to participate. Forty percent of the participants (34\/85) were females, and 78% (66\/85) were white. HCV prevalence among participants was 5% (4\/85), all of whom were females. History of heroin use was reported by 15% (13\/85) and it was associated with HCV seropositivity; 100% (4\/4) of all HCV-positive individuals reported the use of heroin vs only 11% (9\/81) of HCV-negative individuals (P = .0004).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our study showed a high prevalence of HCV among adolescents attending a drug rehabilitation center with high acceptance of POC HCV testing.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpids\/piz065","type":"journal-article","created":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T11:30:14Z","timestamp":1566387014000},"page":"437-441","source":"Crossref","is-referenced-by-count":13,"title":["Hepatitis C Virus Screening Among Adolescents Attending a Drug Rehabilitation Center"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3024-1994","authenticated-orcid":false,"given":"Neil Dominic","family":"Fernandes","sequence":"first","affiliation":[{"name":"Department of Pediatrics, MetroHealth Medical Center, Cleveland, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swagata","family":"Banik","sequence":"additional","affiliation":[{"name":"Department of Public Health & Prevention Science, Baldwin Wallace University, Berea, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazha","family":"Abughali","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, MetroHealth Medical Center, Cleveland, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bonisha","family":"Sthapit","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, MetroHealth Medical Center, Cleveland, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neelab","family":"Abdullah","sequence":"additional","affiliation":[{"name":"Department of Public Health & Prevention Science, Baldwin Wallace University, Berea, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8383-091X","authenticated-orcid":false,"given":"Philip","family":"Fragassi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, MetroHealth Medical Center, Cleveland, Ohio, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,10,11]]},"reference":[{"key":"2020091707241933100_CIT0001","doi-asserted-by":"crossref","first-page":"293","DOI":"10.7326\/M13-1133","article-title":"Chronic hepatitis C virus infection in the United States, National Health and Nutrition Examination Survey 2003 to 2010","volume":"160","author":"Denniston","year":"2014","journal-title":"Ann Intern Med"},{"key":"2020091707241933100_CIT0002","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1056\/NEJMp1302973","article-title":"Hepatitis C in the United States","volume":"368","author":"Holmberg","year":"2013","journal-title":"N Engl J Med"},{"key":"2020091707241933100_CIT0003","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1002\/hep.30297","article-title":"Estimating prevalence of hepatitis C virus infection in the United States, 2013-2016","volume":"69","author":"Hofmeister","year":"2019","journal-title":"Hepatology"},{"key":"2020091707241933100_CIT0004","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1053\/j.gastro.2018.02.035","article-title":"Individual state hepatitis C data supports expanding screening beyond baby boomers to all adults","volume":"154","author":"Morse","year":"2018","journal-title":"Gastroenterology"},{"key":"2020091707241933100_CIT0005","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.3748\/wjg.v24.i24.2555","article-title":"Hepatitis C virus infection in children in the era of direct-acting antiviral","volume":"24","author":"Pawlowska","year":"2018","journal-title":"World J Gastroenterol"},{"key":"2020091707241933100_CIT0006","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/S1471-4906(03)00178-9","article-title":"Hepatitis C virus infection: when silence is deception","volume":"24","author":"Racanelli","year":"2003","journal-title":"Trends Immunol"},{"volume-title":"HCV FAQs for Health Professionals, Division of Viral Hepatitis. 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