{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:32:47Z","timestamp":1762522367463,"version":"3.37.3"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T00:00:00Z","timestamp":1571616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"Fondo Europeo de Desarrollo Regional","doi-asserted-by":"publisher","award":["PI18\/00223","AC16\/00025"],"award-info":[{"award-number":["PI18\/00223","AC16\/00025"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["SLT006\/17\/00199","SLT008\/18\/00193","SGR00742"],"award-info":[{"award-number":["SLT006\/17\/00199","SLT008\/18\/00193","SGR00742"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fundaci\u00f3n God\u00eda and CIBER en Epidemiolog\u00eda y Salud P\u00fablica"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Neisseria meningitidis serogroup B (MenB) is the most frequent cause of invasive meningococcal disease (IMD) in Spain. The multicomponent vaccine against MenB (4CMenB) was approved in Spain in January 2014.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We present 4 cases of children who developed MenB-associated IMD despite previous vaccination with 4CMenB. Extensive immunologic diagnostic work-up was performed in order to rule out any immunodeficiency. Also, molecular characterization of the MenB strain was conducted to determine whether bacterial antigens matched vaccine antigens.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among the 4 patients (2 girls), 2 had previous risk factors for IMD (recurrent bacterial meningitis of unknown origin and treatment with eculizumab). All patients developed meningitis, but only 2 developed septic shock; they were all cured without sequelae. No other primary or secondary immunodeficiencies were detected. MenB sequence type 213 was identified in 3 cases. With the exception of neisserial heparin-binding antigen peptide 465 present in 1 isolate, the rest of the isolated strains harbored vaccine antigen variants that did not match antigen variants included in the vaccine.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We present 4 children who developed MenB-associated IMD despite previous vaccination with 4CMenB. In 2 cases, the antibodies induced by 4CMenB likely were not effective against the isolated strains. A high level of suspicion for IMD seems advisable regardless of the patient\u2019s vaccination history.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpids\/piz071","type":"journal-article","created":{"date-parts":[[2019,9,28]],"date-time":"2019-09-28T03:02:28Z","timestamp":1569639748000},"page":"454-459","source":"Crossref","is-referenced-by-count":6,"title":["Meningococcal Serogroup B Disease in Vaccinated Children"],"prefix":"10.1093","volume":"9","author":[{"given":"Aleix","family":"Soler-Garcia","sequence":"first","affiliation":[{"name":"Malalties Infeccioses i Resposta Inflamat\u00f2ria Sist\u00e8mica en Pediatria, Institut de Recerca Pedi\u00e0trica, Hospital Sant Joan de D\u00e9u, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariona","family":"Fern\u00e1ndez de Sevilla","sequence":"additional","affiliation":[{"name":"Malalties Infeccioses i Resposta Inflamat\u00f2ria Sist\u00e8mica en Pediatria, Institut de Recerca Pedi\u00e0trica, Hospital Sant Joan de D\u00e9u, Barcelona, Spain"},{"name":"Departament de Pediatria, Universitat de Barcelona, Barcelona, Spain"},{"name":"CIBER de Epidemiolog\u00eda y Salud P\u00fablica, CIBERESP, Madrid, Spain"},{"name":"Red de Investigaci\u00f3n Translacional en Infectolog\u00eda Pedi\u00e1trica, RITIP, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"Abad","sequence":"additional","affiliation":[{"name":"Unidad de Neisseria, Listeria y Bordetella, Centro Nacional de Microbiolog\u00eda, Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Esteva","sequence":"additional","affiliation":[{"name":"Malalties Infeccioses i Resposta Inflamat\u00f2ria Sist\u00e8mica en Pediatria, Institut de Recerca Pedi\u00e0trica, Hospital Sant Joan de D\u00e9u, Barcelona, Spain"},{"name":"CIBER de Epidemiolog\u00eda y Salud P\u00fablica, CIBERESP, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laia","family":"Alsina","sequence":"additional","affiliation":[{"name":"Malalties Infeccioses i Resposta Inflamat\u00f2ria Sist\u00e8mica en Pediatria, Institut de Recerca Pedi\u00e0trica, Hospital Sant Joan de D\u00e9u, Barcelona, Spain"},{"name":"Departament de Pediatria, Universitat de Barcelona, Barcelona, Spain"},{"name":"Clinical Immunology and Primary Immunodeficiencies Unit, Pediatric Allergy and Clinical Immunology Department, Hospital Sant Joan de D\u00e9u, Barcelona, Spain"},{"name":"Clinical Immunology Unit Hospital Sant Joan de D\u00e9u-Hospital Cl\u00ednic Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Unidad de Neisseria, Listeria y Bordetella, Centro Nacional de Microbiolog\u00eda, Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Mu\u00f1oz-Almagro","sequence":"additional","affiliation":[{"name":"Malalties Infeccioses i Resposta Inflamat\u00f2ria Sist\u00e8mica en Pediatria, Institut de Recerca Pedi\u00e0trica, Hospital Sant Joan de D\u00e9u, Barcelona, Spain"},{"name":"CIBER de Epidemiolog\u00eda y Salud P\u00fablica, CIBERESP, Madrid, Spain"},{"name":"Red de Investigaci\u00f3n Translacional en Infectolog\u00eda Pedi\u00e1trica, RITIP, Madrid, Spain"},{"name":"Departament de Medicina, Universitat Internacional de Catalunya, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoni","family":"Noguera-Julian","sequence":"additional","affiliation":[{"name":"Malalties Infeccioses i Resposta Inflamat\u00f2ria Sist\u00e8mica en Pediatria, Institut de Recerca Pedi\u00e0trica, Hospital Sant Joan de D\u00e9u, Barcelona, Spain"},{"name":"Departament de Pediatria, Universitat de Barcelona, Barcelona, Spain"},{"name":"CIBER de Epidemiolog\u00eda y Salud P\u00fablica, CIBERESP, Madrid, Spain"},{"name":"Red de Investigaci\u00f3n Translacional en Infectolog\u00eda Pedi\u00e1trica, RITIP, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,10,21]]},"reference":[{"key":"2020091707142017300_CIT0001","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1586\/14760584.2015.1071670","article-title":"Multivalent meningococcal serogroup B vaccines: challenges in predicting protection and measuring effectiveness","volume":"14","author":"Poolman","year":"2015","journal-title":"Expert Rev Vaccines"},{"key":"2020091707142017300_CIT0002","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.vacun.2014.01.001","article-title":"Enfermedad meningoc\u00f3cica en Espa\u00f1a (1940\u20132012). 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