{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:19:10Z","timestamp":1790518750492,"version":"4.1.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T00:00:00Z","timestamp":1581984000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"French National Health Ministry Hospital Research Program","award":["2008-A01239-46"],"award-info":[{"award-number":["2008-A01239-46"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,31]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Congenital cytomegalovirus (CMV) remains an important healthcare burden, resulting from primary or secondary infection in pregnant women. Exposure to young children\u2019s saliva is a major risk factor, as prevalence of CMV shedding can reach 34%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross-sectional, multicenter, nationwide study was conducted in randomly selected day care centers (DCCs), and complemented with a survey among parents and DCCs. All children aged &amp;gt;3 months were eligible. The study measured the CMV shedding prevalence in children\u2019s saliva and described CMV genotypes epidemiology. The risk factors for CMV shedding and high viral load were evaluated using multivariable models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 93 DCCs participated. Among the 1770 enrolled children with evaluable samples, the CMV shedding prevalence was 40% (713\/1770, 95% confidence interval, 34.6\u201346.1), independently associated with children aged between 12 and 18 months, history of CMV infection in \u22651 parents, a mid-level income. Prevalence increased with DCC staff workload and attending children number. Viral load was \u22655 log-copies CMV\/mL in 48% (342\/713). Risk factors for higher viral load included children aged between 12 and 18 months, and still being breastfed. The most frequent genotype combinations were gB1-gN4c-gH2 (6.9%), gB1-gN2-gH2 (6.3%), gB4a-gN3a-gH1 (6.3%), and gB1-gN3b-gH2 (5,7%). CMV awareness was low in parents: their serological status was unknown by 72% of mothers and 82% of fathers. Only 41% knew something about CMV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CMV shedding was independently associated with risk factors related to the children, family and DCC. Some of these risk factors may influence prevention strategies, including through an improved information provided to parents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Trials Registration<\/jats:title><jats:p>NCT01704222.<\/jats:p><\/jats:sec>","DOI":"10.1093\/jpids\/piz097","type":"journal-article","created":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T20:12:53Z","timestamp":1581538373000},"page":"686-694","source":"Crossref","is-referenced-by-count":15,"title":["Cytomegalovirus (CMV) Shedding in French Day-Care Centers: A Nationwide Study of Epidemiology, Risk Factors, Centers\u2019 Practices, and Parents\u2019 Awareness of CMV"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9787-1421","authenticated-orcid":false,"given":"Sophie","family":"Alain","sequence":"first","affiliation":[{"name":"National Reference Center for Herpesviruses, Limoges, France"},{"name":"Inserm U1092 University Limoges, Limoges, France"},{"name":"Bacteriology, Virology, Hygiene Department, CHU Limoges, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Garnier-Geoffroy","sequence":"additional","affiliation":[{"name":"National Reference Center for Herpesviruses, Limoges, France"},{"name":"Inserm U1092 University Limoges, Limoges, France"},{"name":"Bacteriology, Virology, Hygiene Department, CHU Limoges, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana\u00efs","family":"Labrunie","sequence":"additional","affiliation":[{"name":"Centre for Methodology and Data Management (Cebimer Department), CHU Limoges, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lie","family":"Montan\u00e9","sequence":"additional","affiliation":[{"name":"Paediatrics Department, CHU Limoges, 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