{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:54:02Z","timestamp":1761648842968,"version":"3.37.3"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"e Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","award":["APQ-01059-14","APQ-01403-14","APQ-00487-16"],"award-info":[{"award-number":["APQ-01059-14","APQ-01403-14","APQ-00487-16"]}]},{"DOI":"10.13039\/501100007378","name":"Federal University of Juiz de Fora","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007378","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Evaluation of the in-vivo anti-inflammatory activity of the methanolic extract obtained from the aerial parts of Mitracarpus frigidus (MFM) in the infection caused by two Salmonella strains and its chemical fingerprint by UFLC-quadrupole time of flight-MS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The efficacy of MFM was investigated in a classical in-vivo Salmonella infection mouse model. A Salmonella reference strain (ATCC 13311) and a clinical isolate were used to infect mice and then MFM was orally administered during 14 days. At the end of the treatment with MFM, the infection and inflammatory levels were assayed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>MFM treatment showed a significant reduction in mice mortality by Salmonella infection and, also, did not cause alterations in the liver function. Inhibitions of inflammatory and oxidative stress mediators [malondialdehyde (MDA), catalase, and metalloproteinase] were possibly involved in the observed effects. Chlorogenic acid, clarinoside, quercetin-pentosylhexoside, rutin, kaempferol-3O-rutinoside, kaempferol-rhamnosylhexoside and 2-azaanthraquinone were identified in MFM.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>MFM was effective in some inflammatory parameters, in the experimental conditions that were used in the study. The results presented in this study and the previous in-vitro anti-Salmonella activity reported by our research group reinforce the importance of MFM studies to considerer it as an alternative treatment for salmonellosis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpp\/rgaa001","type":"journal-article","created":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T04:13:53Z","timestamp":1609474433000},"page":"82-92","source":"Crossref","is-referenced-by-count":5,"title":["<i>Mitracarpus frigidus<\/i> (Rubiaceae) inhibits inflammatory and oxidative stress mediators in <i>Salmonella<\/i> sp. mouse infection"],"prefix":"10.1093","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0167-2277","authenticated-orcid":false,"given":"Rodrigo Luiz","family":"Fabri","sequence":"first","affiliation":[{"name":"Bioactive Natural Products Laboratory, Department of Biochemistry, Biological Sciences Institute, Federal University of Juiz de Fora , Juiz de Fora, 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MG,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle Maria de Oliveira","family":"Arag\u00e3o","sequence":"additional","affiliation":[{"name":"Bioactive Natural Products Laboratory, Department of Biochemistry, Biological Sciences Institute, Federal University of Juiz de Fora , Juiz de Fora, MG,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana L\u00facia Pires","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Laboratory of Bacteriology, University Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro , Rio de Janeiro, RJ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2088-8871","authenticated-orcid":false,"given":"Jair Adriano Kopke","family":"de Aguiar","sequence":"additional","affiliation":[{"name":"Glycoconjugate Analysis Laboratory, Department of Biochemistry, Biological Sciences Institute, 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