{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T15:50:02Z","timestamp":1775058602472,"version":"3.50.1"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860647"],"award-info":[{"award-number":["81860647"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Foundation for Directors of Key Laboratory of Basic Pharmacology of Ministry of Education","award":["JCYL-Z-002"],"award-info":[{"award-number":["JCYL-Z-002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To assess the effect of sildenafil on monocrotaline-induced right ventricular (RV) remodeling and investigate the possible mechanism.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Rats were subcutaneously injected with monocrotaline to establish an RV remodeling model and then administered sildenafil (25 mg\/kg) from days 1 to 28. After 28 days of administration, the RV systolic pressure and the RV hypertrophy index (RVHI) were measured. The morphology of the right ventricle was observed by H&amp;E staining. The ultrastructure of the right ventricle was observed using a transmission electron microscope. The myocardial apoptosis of the right ventricle was evaluated by TUNEL staining. The protein expression of apoptosis-related proteins and PPARs were examined by western blotting.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>The results indicated that sildenafil decreased the RV systolic pressure and RVHI, and improved the microstructure and ultrastructure of the right ventricle in monocrotaline-induced rats. In addition, sildenafil suppressed myocardial apoptosis and promoted the protein expression of PPARs of the right ventricle in monocrotaline-induced rats.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Sildenafil inhibits RV remodeling in monocrotaline-induced rats, which might be partially mediated by reducing myocardial apoptosis and activating PPARs.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpp\/rgaa017","type":"journal-article","created":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T04:13:53Z","timestamp":1609474433000},"page":"145-151","source":"Crossref","is-referenced-by-count":3,"title":["Sildenafil improves right ventricular remodelling in monocrotaline-induced rats by decreasing myocardial apoptosis and activating peroxisome proliferator-activated receptors"],"prefix":"10.1093","volume":"73","author":[{"given":"Ye-li","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University , Zunyi,","place":["China"]},{"name":"Key Laboratory of Basic Pharmacology of Guizhou Province, Zunyi Medical University , Zunyi,","place":["China"]},{"name":"Department of Pharmacology, School of Pharmacy, Zunyi Medical University , Zunyi,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-qi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Zunyi Medical University, Zhuhai Campus , Zhuhai,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan-qun","family":"Zeng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University , Zunyi,","place":["China"]},{"name":"Key Laboratory of Basic Pharmacology of Guizhou Province, Zunyi Medical University , Zunyi,","place":["China"]},{"name":"Department of Pharmacology, School of Pharmacy, Zunyi Medical University , Zunyi,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-ying","family":"Lin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University , Zunyi,","place":["China"]},{"name":"Key Laboratory of Basic Pharmacology of Guizhou Province, Zunyi Medical University , Zunyi,","place":["China"]},{"name":"Department of Pharmacology, School of Pharmacy, Zunyi Medical University , Zunyi,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-tong","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University , Zunyi,","place":["China"]},{"name":"Key Laboratory of Basic Pharmacology of Guizhou Province, Zunyi Medical University , Zunyi,","place":["China"]},{"name":"Department of Pharmacology, School of Pharmacy, Zunyi Medical University , Zunyi,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing-qiao","family":"Ren","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University , Zunyi,","place":["China"]},{"name":"Key Laboratory of Basic Pharmacology of Guizhou Province, Zunyi Medical University , Zunyi,","place":["China"]},{"name":"Department of Pharmacology, School of Pharmacy, Zunyi Medical University , Zunyi,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2346-6404","authenticated-orcid":false,"given":"Dan-li","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University , Zunyi,","place":["China"]},{"name":"Key Laboratory of Basic Pharmacology of Guizhou Province, Zunyi Medical University , Zunyi,","place":["China"]},{"name":"Department of Pharmacology, School of Pharmacy, Zunyi Medical University , 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