{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:29:13Z","timestamp":1790015353956,"version":"4.0.1"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T00:00:00Z","timestamp":1612396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["#2013\/05355-1"],"award-info":[{"award-number":["#2013\/05355-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the antibacterial, antifungal and anthelmintic activities of the ethanolic extract (EEMz), fractions (LPFMz and HPFMz) and compounds isolated from the leaves of Manilkara zapota L. P. Royen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Extract and fractions were produced by turbolization. LPFMz fraction was analysed by gas chromatography\u2013mass spectrometry. The isolated compounds from HPFMz were purified by flash and preparative chromatographic methods, and chemically characterised by UPLC-ESITOFMS, optical rotation, and one- and two-dimensional 1H and 13C NMR techniques. Anthelmintic against Strongyloides venezuelensis and antimicrobial activities against Candida albicans, Trichophyton rubrum and Staphylococcus aureus were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key findings<\/jats:title>\n                    <jats:p>EEMz showed mainly phenolic compounds and pentacyclic triterpenes from \u039412-oleane\/\u039412-ursane series. Chlorogenic acid, myricetin-3-O-\u03b2-D-glucopyranoside, mearnsitrin, germanicol and germanicol acetate were reported to M. zapota leaves for the first time in this work. EEMz, HPFMz, LPFMz showed significative activity against C. albicans (16 \u00b5g\/mL), while isolated flavonoids were active against S. aureus (&amp;lt;32 \u00b5g\/mL). EEMz, phenolic-rich compounds (F2), and chlorogenic acid were potentially active against S. venezuelensis at 24 h.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>M. zapota and its bioactive compound can be eligible such as a potential phytomedicine for the treatment of microbial and strongyloidiasis drug-resistant infections.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jpp\/rgaa030","type":"journal-article","created":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T23:13:53Z","timestamp":1609456433000},"page":"377-387","source":"Crossref","is-referenced-by-count":9,"title":["Antimicrobial and anthelmintic activities of the ethanolic extract, fractions and isolated compounds from\n                    <i>Manilkara zapota<\/i>\n                    L. P. Royen (Sapotaceae)"],"prefix":"10.1093","volume":"73","author":[{"given":"Layany Carolyny","family":"Mour\u00e3o Mulvaney","sequence":"first","affiliation":[{"name":"Chemical, Biological and Agricultural Pluridisciplinary Research Center, University of Campinas , Campinas, SP,","place":["Brazil"]},{"name":"CNRS- Institut de Chimie des Substances Naturelles , Gif-sur-Yvette,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8238-3380","authenticated-orcid":false,"given":"Francisco Humberto","family":"Xavier-J\u00fanior","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biotecnologia, Universidade Potiguar (UnP) , Campus Salgado Filho, Natal, RN,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice M S","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Sorbonne Universite\u0301s, UPMC Univ Paris 06, CNRS, Laboratoire de Biodiversite\u0301 et Biotechnologies Microbiennes (LBBM), Observatoire Oce\u0301anologique , Banyuls-sur-mer,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Stien","sequence":"additional","affiliation":[{"name":"CNRS- Institut de Chimie des Substances Naturelles , Gif-sur-Yvette,","place":["France"]},{"name":"Sorbonne Universite\u0301s, UPMC Univ Paris 06, CNRS, Laboratoire de Biodiversite\u0301 et Biotechnologies Microbiennes (LBBM), Observatoire Oce\u0301anologique , Banyuls-sur-mer,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silmara Marques","family":"Allegretti","sequence":"additional","affiliation":[{"name":"Department of Animal Biology, Institute of Biology, University of Campinas , Campinas, SP,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera L\u00facia","family":"Garcia","sequence":"additional","affiliation":[{"name":"Chemical, Biological and Agricultural Pluridisciplinary Research Center, University of Campinas , Campinas, SP,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,3,1]]},"reference":[{"key":"2026041420233233500_CIT0001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/5245021","article-title":"Emerging and neglected infectious diseases: insights, advances, and challenges","volume":"6","author":"Nii-Trebi","year":"2017","journal-title":"Biomed Res Int"},{"key":"2026041420233233500_CIT0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13756-017-0208-x","article-title":"The threat of antimicrobial resistance in developing countries: causes and control strategies","volume":"6","author":"Ayukekbong","year":"2017","journal-title":"Antimicrob Resist Infect Control"},{"key":"2026041420233233500_CIT0003","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1089\/acm.2013.0036","article-title":"A comparison of the anti- Staphylococcus aureus activity of extracts from commonly used medicinal Plants","volume":"5","author":"Snowden","year":"2014","journal-title":"J Altern Complement Med"},{"key":"2026041420233233500_CIT0004","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.jaad.2018.05.041","article-title":"A cohort study of risk factors, clinical presentations, and outcomes for dermatophyte, nondermatophyte, and mixed toenail infections","volume":"6","author":"Salakshna","year":"2018","journal-title":"J Am Acad Dermatol"},{"key":"2026041420233233500_CIT0005","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.simyco.2018.02.004","article-title":"Phylogeny of dermatophytes with genomic character evaluation of clinically distinct Trichophyton rubrum and T-violaceum","volume":"89","author":"Zhan","year":"2018","journal-title":"Stud Mycol"},{"key":"2026041420233233500_CIT0006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mycmed.2016.10.002","article-title":"Anti-Candida albicans natural products, sources of new antifungal drugs: a review","volume":"1","author":"Zida","year":"2017","journal-title":"J Mycol Med"},{"key":"2026041420233233500_CIT0007","doi-asserted-by":"crossref","first-page":"e1582","DOI":"10.1371\/journal.pntd.0001582","article-title":"A research agenda for helminth diseases of humans: the problem of helminthiases","volume":"4","author":"Lustigman","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"2026041420233233500_CIT0008","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.trstmh.2009.02.013","article-title":"Strongyloidiasis - 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