{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T19:58:35Z","timestamp":1790452715229,"version":"4.1.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773971"],"award-info":[{"award-number":["81773971"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Double First-rate Discipline Innovation Team of China Pharmaceutical University","award":["CPU2018GF07"],"award-info":[{"award-number":["CPU2018GF07"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Sepsis-associated acute lung injury (ALI) occurs with the highest morbidity and carries the highest mortality rates among the pathogenies of ALI. Ruscogenin (RUS) has been found to exhibit anti-inflammation property and rescue lipopolysaccharide-induced ALI, but little is known about its role in sepsis-triggered ALI. The aim of this study was to investigate the potential role of RUS in sepsis-induced ALI and the probable mechanism.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Mice model of cecal ligation and puncture (CLP) was replicated, and three doses of RUS (0.01, 0.03 and 0.1 mg\/kg) were administrated 1 h before CLP surgeries.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>RUS significantly extended the survival time and attenuated the lung pathological injury, oedema and vascular leakage in sepsis-induced ALI mice. RUS efficiently decreased the level of MPO in lung tissue and the WBC, NEU counts in BALF. In addition, RUS rescued the expression of VE-cadherin and p120-catenin and suppressed the TLR4\/Src signalling in lung tissue.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>RUS attenuated sepsis-induced ALI via protecting pulmonary endothelial barrier and regulating TLR4\/Src\/p120-catenin\/VE-cadherin signalling pathway.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpp\/rgaa039","type":"journal-article","created":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T04:13:53Z","timestamp":1609474433000},"page":"893-900","source":"Crossref","is-referenced-by-count":31,"title":["Ruscogenin attenuates sepsis-induced acute lung injury and pulmonary endothelial barrier dysfunction via TLR4\/Src\/p120-catenin\/VE-cadherin signalling pathway"],"prefix":"10.1093","volume":"73","author":[{"given":"Yuwei","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Department of Pharmacology of Chinese Material Medica, School of Traditional Chinese Pharmacy, China Pharmaceutical University , Nanjing, Jiangsu ,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixuan","family":"Xue","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Department of Pharmacology of Chinese Material Medica, School of Traditional Chinese Pharmacy, China Pharmaceutical University , Nanjing, Jiangsu ,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhao","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Department of Pharmacology of Chinese Material Medica, School of Traditional Chinese Pharmacy, China Pharmaceutical University , Nanjing, Jiangsu ,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiazhi","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Department of Pharmacology of Chinese Material Medica, School of Traditional Chinese Pharmacy, China Pharmaceutical University , Nanjing, Jiangsu ,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Dai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Department of Pharmacology of Chinese Material Medica, School of Traditional Chinese Pharmacy, China Pharmaceutical University , Nanjing, Jiangsu ,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Department of Pharmacology of Chinese Material Medica, School of Traditional Chinese Pharmacy, China Pharmaceutical University , Nanjing, Jiangsu ,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junping","family":"Kou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Department of Pharmacology of Chinese Material Medica, School of Traditional Chinese Pharmacy, China Pharmaceutical University , Nanjing, Jiangsu ,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3662-4398","authenticated-orcid":false,"given":"Yuanyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Department of Pharmacology of Chinese Material Medica, School of Traditional Chinese Pharmacy, China Pharmaceutical University , Nanjing, Jiangsu ,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,7,1]]},"reference":[{"key":"2024103012061452200_CIT0001","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41572-019-0069-0","article-title":"Acute respiratory distress syndrome","volume":"5","author":"Matthay","year":"2019","journal-title":"Nat Rev Dis Primers"},{"key":"2024103012061452200_CIT0002","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.resp.2014.10.006","article-title":"Biomarkers in acute lung injury","volume":"209","author":"Mokra","year":"2015","journal-title":"Respir Physiol Neurobiol"},{"key":"2024103012061452200_CIT0003","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1183\/09031936.00221611","article-title":"Effectiveness of an inspiratory pressure-limited approach to mechanical ventilation in septic patients","volume":"41","author":"Martin-Loeches","year":"2013","journal-title":"Eur Respir J"},{"key":"2024103012061452200_CIT0004","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(18)30696-2","article-title":"Sepsis and septic shock","volume":"392","author":"Cecconi","year":"2018","journal-title":"Lancet"},{"key":"2024103012061452200_CIT0005","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1038\/nm.2843","article-title":"The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis","volume":"18","author":"Schmidt","year":"2012","journal-title":"Nat Med"},{"key":"2024103012061452200_CIT0006","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1172\/JCI60331","article-title":"The acute respiratory distress syndrome","volume":"122","author":"Matthay","year":"2012","journal-title":"J Clin Invest"},{"key":"2024103012061452200_CIT0007","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1172\/JCI77701","article-title":"HIF2\u03b1 signaling inhibits adherens junctional disruption in acute lung injury","volume":"125","author":"Gong","journal-title":"J Clin Invest 2015"},{"key":"2024103012061452200_CIT0008","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1080\/15548627.2018.1476811","article-title":"RAB26-dependent autophagy protects adherens junctional integrity in acute lung injury","volume":"14","author":"Dong","year":"2018","journal-title":"Autophagy"},{"key":"2024103012061452200_CIT0009","doi-asserted-by":"crossref","first-page":"C987","DOI":"10.1152\/ajpcell.00522.2003","article-title":"VE-cadherin: adhesion at arm\u2019s length","volume":"286","author":"Vincent","year":"2004","journal-title":"Am J Physiol Cell Physiol"},{"key":"2024103012061452200_CIT0010","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1083\/jcb.201205029","article-title":"P120-catenin binding masks an endocytic signal conserved in classical cadherins","volume":"199","author":"Nanes","year":"2012","journal-title":"J Cell Biol"},{"key":"2024103012061452200_CIT0011","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1001\/jama.2013.2194","article-title":"Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial","volume":"309","author":"Opal","year":"2013","journal-title":"JAMA"},{"key":"2024103012061452200_CIT0012","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1007\/s00134-010-1799-3","article-title":"Mechanical ventilation modulates Toll-like receptor signaling pathway in a sepsis-induced lung injury model","volume":"36","author":"Villar","year":"2020","journal-title":"Intensive Care Med"},{"key":"2024103012061452200_CIT0013","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1186\/s13054-018-2237-0","article-title":"Mechanical ventilation enhances extrapulmonary sepsis-induced lung injury: role of WISP1-\u03b1v\u03b25 integrin pathway in TLR4-mediated inflammation and injury","volume":"22","author":"Ding","year":"2018","journal-title":"Crit Care"},{"key":"2024103012061452200_CIT0014","doi-asserted-by":"crossref","first-page":"L332","DOI":"10.1152\/ajplung.00247.2018","article-title":"Histone deacetylase 6 regulates endothelial MyD88-dependent canonical TLR signaling, lung inflammation, and alveolar remodeling in the developing lung","volume":"317","author":"Menden","year":"2019","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2024103012061452200_CIT0015","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1002\/jcb.28199","article-title":"Shikonin improve sepsis-induced lung injury via regulation of miRNA-140-5p\/TLR4-a in vitro and vivo study","volume":"121","author":"Zhang","year":"2020","journal-title":"J Cell Biochem"},{"key":"2024103012061452200_CIT0016","doi-asserted-by":"crossref","first-page":"13437","DOI":"10.1074\/jbc.M707986200","article-title":"TLR4 signaling is coupled to SRC family kinase activation, tyrosine phosphorylation of zonula adherens proteins, and opening of the paracellular pathway in human lung microvascular endothelia","volume":"283","author":"Gong","year":"2008","journal-title":"J Biol Chem"},{"key":"2024103012061452200_CIT0017","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jep.2016.01.037","article-title":"Ophiopogon japonicus--A phytochemical, ethnomedicinal and pharmacological review","volume":"181","author":"Chen","year":"2016","journal-title":"J Ethnopharmacol"},{"key":"2024103012061452200_CIT0018","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.intimp.2011.10.018","article-title":"Ruscogenin inhibits lipopolysaccharide-induced acute lung injury in mice: involvement of tissue factor, inducible NO synthase and nuclear factor (NF)-\u03baB","volume":"12","author":"Sun","year":"2012","journal-title":"Int Immunopharmacol"},{"key":"2024103012061452200_CIT0019","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.intimp.2013.03.010","article-title":"Ruscogenin attenuates monocrotaline-induced pulmonary hypertension in rats","volume":"16","author":"Bi","year":"2013","journal-title":"Int Immunopharmacol"},{"key":"2024103012061452200_CIT0020","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.3390\/ijms17091418","article-title":"Ruscogenin attenuates cerebral ischemia-induced blood-brain barrier dysfunction by suppressing TXNIP\/NLRP3 inflammasome activation and the MAPK pathway","volume":"17","author":"Cao","year":"2016","journal-title":"Int J Mol Sci"},{"key":"2024103012061452200_CIT0021","doi-asserted-by":"crossref","first-page":"e797","DOI":"10.1097\/CCM.0000000000003201","article-title":"Cecal ligation and puncture alters glucocorticoid receptor expression","volume":"46","author":"Abraham","year":"2008","journal-title":"Crit Care Med"},{"key":"2024103012061452200_CIT0022","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1177\/0885066617711882","article-title":"Epidemiology and changes in mortality of sepsis after the implementation of surviving sepsis campaign guidelines","volume":"34","author":"Herr\u00e1n-Monge","year":"2019","journal-title":"J Intensive Care Med"},{"key":"2024103012061452200_CIT0023","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1097\/01.ccm.0000435676.68435.56","article-title":"Impact of distinct definitions of acute lung injury on its incidence and outcomes in Brazilian ICUs: prospective evaluation of 7,133 patients","volume":"42","author":"Caser","year":"2014","journal-title":"Crit Care Med"},{"key":"2024103012061452200_CIT0024","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s11908-016-0535-8","article-title":"Differential paradigms in animal models of sepsis","volume":"18","author":"Kingsley","year":"2016","journal-title":"Curr Infect Dis Rep"},{"key":"2024103012061452200_CIT0025","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.tim.2011.01.001","article-title":"Cecal ligation and puncture: the gold standard model forpolymicrobial sepsis?","volume":"19","author":"Dejager","year":"2011","journal-title":"Trends Microbiol"},{"key":"2024103012061452200_CIT0026","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.lfs.2019.02.039","article-title":"Ameliorative effect of gossypin against acute lung injury in experimental sepsis model of rats","volume":"221","author":"Cinar","year":"2019","journal-title":"Life Sci"},{"key":"2024103012061452200_CIT0027","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40635-016-0096-z","article-title":"Sepsis modeling in mice: ligation length is a major severity factor in cecal ligation and puncture","volume":"4","author":"Ruiz","year":"2016","journal-title":"Intensive Care Med Exp"},{"key":"2024103012061452200_CIT0028","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.intimp.2016.11.011","article-title":"Systematic investigation on the turning point of over-inflammation to immunosuppression in CLP mice model and their characteristics","volume":"42","author":"Deng","year":"2017","journal-title":"Int Immunopharmacol"},{"key":"2024103012061452200_CIT0029","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nri.2017.36","article-title":"The immunopathology of sepsis and potential therapeutic targets","volume":"17","author":"van der Poll","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"2024103012061452200_CIT0030","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1007\/s10620-019-05581-y","article-title":"Gut leakage of fungal-derived inflammatory mediators: part of a gut-liver-kidney axis in bacterial sepsis","volume":"64","author":"Amornphimoltham","year":"2019","journal-title":"Dig Dis Sci"},{"key":"2024103012061452200_CIT0031","doi-asserted-by":"crossref","first-page":"16113","DOI":"10.1038\/nmicrobiol.2016.113","article-title":"Enrichment of the lung microbiome with gut bacteria in sepsis and the acute respiratory distress syndrome","volume":"1","author":"Dickson","year":"2016","journal-title":"Nat Microbiol"},{"key":"2024103012061452200_CIT0032","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s00281-017-0639-8","article-title":"Cytokine storm and sepsis disease pathogenesis","volume":"39","author":"Chousterman","year":"2017","journal-title":"Semin Immunopathol"},{"key":"2024103012061452200_CIT0033","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.abb.2018.01.004","article-title":"Myeloperoxidase: its role for host defense, inflammation, and neutrophil function","volume":"640","author":"Aratani","year":"2018","journal-title":"Arch Biochem Biophys"},{"key":"2024103012061452200_CIT0034","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.cca.2016.03.017","article-title":"Neutrophil left shift and white blood cell count as markers of bacterial infection","volume":"457","author":"Honda","year":"2016","journal-title":"Clin Chim Acta"},{"key":"2024103012061452200_CIT0035","doi-asserted-by":"crossref","first-page":"293","DOI":"10.2119\/molmed.2010.00138","article-title":"Contribution of neutrophils to acute lung injury","volume":"17","author":"Grommes","year":"2011","journal-title":"Mol Med"},{"key":"2024103012061452200_CIT0036","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1164\/rccm.200207-664OC","article-title":"Early alterations in neutrophil activation are associated with outcome in acute lung injury","volume":"167","author":"Yang","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"2024103012061452200_CIT0037","doi-asserted-by":"crossref","first-page":"L51","DOI":"10.1152\/ajplung.00028.2005","article-title":"Role of alveolar macrophage and migrating neutrophils in hemorrhage-induced priming for ALI subsequent to septic challenge","volume":"290","author":"Lomas-Neira","year":"2006","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2024103012061452200_CIT0038","doi-asserted-by":"crossref","first-page":"e124061","DOI":"10.1172\/jci.insight.124061","article-title":"Integrating molecular pathogenesis and clinical translation in sepsis-induced acute respiratory distress syndrome","volume":"4","author":"Englert","year":"2019","journal-title":"JCI Insight"},{"key":"2024103012061452200_CIT0039","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1161\/CIRCRESAHA.116.306534","article-title":"Protein interactions at endothelial junctions and signaling mechanisms regulating endothelial permeability","volume":"120","author":"Komarova","year":"2017","journal-title":"Circ Res"},{"key":"2024103012061452200_CIT0040","doi-asserted-by":"crossref","first-page":"4849","DOI":"10.1007\/s00018-015-1973-4","article-title":"Rab5-mediated VE-cadherin internalization regulates the barrier function of the lung microvascular endothelium","volume":"72","author":"Yang","year":"2015","journal-title":"Cell Mol Life Sci"},{"key":"2024103012061452200_CIT0041","doi-asserted-by":"crossref","first-page":"5141","DOI":"10.1091\/mbc.e05-05-0440","article-title":"P120-Catenin regulates clathrin-dependent endocytosis of VE-cadherin","volume":"16","author":"Xiao","year":"2005","journal-title":"Mol Biol Cell"},{"key":"2024103012061452200_CIT0042","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.intimp.2019.04.009","article-title":"Inhibition of MRP4 alleviates sepsis-induced acute lung injury in rats","volume":"72","author":"Xia","year":"2019","journal-title":"Int Immunopharmacol"},{"key":"2024103012061452200_CIT0043","doi-asserted-by":"crossref","first-page":"3180","DOI":"10.4049\/jimmunol.1001252","article-title":"Innate immune function of the adherens junction protein p120-catenin in endothelial response to endotoxin","volume":"186","author":"Wang","year":"2011","journal-title":"J Immunol"},{"key":"2024103012061452200_CIT0044","doi-asserted-by":"crossref","first-page":"L832","DOI":"10.1152\/ajplung.00233.2016","article-title":"Regulation of pulmonary endothelial barrier function by kinases","volume":"311","author":"Barabutis","year":"2016","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2024103012061452200_CIT0045","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3390\/vaccines5040034","article-title":"TLR4 signaling pathway modulators as potential therapeutics in inflammation and sepsis","volume":"5","author":"Kuzmich","year":"2017","journal-title":"Vaccines (Basel)"},{"key":"2024103012061452200_CIT0046","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.3389\/fimmu.2019.02575","article-title":"Siglec-G deficiency ameliorates hyper-inflammation and immune collapse in sepsis via regulating Src activation","volume":"10","author":"Li","year":"2019","journal-title":"Front Immunol"},{"key":"2024103012061452200_CIT0047","doi-asserted-by":"crossref","first-page":"6191","DOI":"10.4049\/jimmunol.1300873","article-title":"Caveolin-1 Tyr14 phosphorylation induces interaction with TLR4 in endothelial cells and mediates MyD88-dependent signaling and sepsis-induced lung inflammation","volume":"191","author":"Jiao","year":"2013","journal-title":"J Immunol"},{"key":"2024103012061452200_CIT0048","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1517\/14728214.2015.1000299","article-title":"Emerging drugs for acute lung injury","volume":"20","author":"Impellizzeri","year":"2015","journal-title":"Expert Opin Emerg Drugs"},{"key":"2024103012061452200_CIT0049","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1254\/jphs.08083FP","article-title":"Possible mechanism of the anti-inflammatory activity of ruscogenin: role of intercellular adhesion molecule-1 and nuclear factor-kappaB","volume":"108","author":"Huang","year":"2008","journal-title":"J Pharmacol Sci"},{"key":"2024103012061452200_CIT0050","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.ejphar.2013.07.036","article-title":"Ruscogenin reduces cerebral ischemic injury via NF-\u03baB-mediated inflammatory pathway in the mouse model of experimental stroke","volume":"714","author":"Guan","year":"2013","journal-title":"Eur J Pharmacol"},{"key":"2024103012061452200_CIT0051","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/1472-6882-14-110","article-title":"Ruscogenin ameliorates diabetic nephropathy by its anti-inflammatory and anti-fibrotic effects in streptozotocin-induced diabetic rat","volume":"14","author":"Lu","year":"2014","journal-title":"BMC Complement Altern Med"},{"key":"2024103012061452200_CIT0052","doi-asserted-by":"crossref","first-page":"652680","DOI":"10.1155\/2014\/652680","article-title":"Ruscogenin ameliorates experimental nonalcoholic steatohepatitis via suppressing lipogenesis and inflammatory pathway","volume":"2014","author":"Lu","year":"2014","journal-title":"Biomed Res Int"}],"container-title":["Journal of Pharmacy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/73\/7\/893\/60218671\/rgaa039.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/73\/7\/893\/60218671\/rgaa039.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T16:49:20Z","timestamp":1730306960000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpp\/article\/73\/7\/893\/6188965"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,1]]},"references-count":52,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2021,7,1]]},"published-print":{"date-parts":[[2021,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jpp\/rgaa039","relation":{},"ISSN":["0022-3573","2042-7158"],"issn-type":[{"value":"0022-3573","type":"print"},{"value":"2042-7158","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,7,1]]},"published":{"date-parts":[[2021,7,1]]}}}