{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T17:40:55Z","timestamp":1780940455917,"version":"3.54.1"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The study was carried out to evaluate the in vivo antiurolithic efficaciousness of an ethyl acetate fraction of Aerva lanata (EAFAL) derived from the hydromethanolic extract of its aerial parts (HMEAL).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In vivo pharmacological potency of EAFAL was assessed by ethylene glycol (EG) induced urolithiasis model in male Wistar albino rats. Urine samples of the animals were analysed for physical parameters, stone promoters, inhibitors along with an evaluation of the biochemical parameters of serum and kidneys. Histopathological investigation of the kidneys was done. The fraction was further subjected to LC-MS and HPLC for its phytochemical evaluation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>EAFAL demonstrated a significant antiurolithic effect by a restoration of the balance between urinary promoters and inhibitors along with an amelioration of the urinary pH. The abnormally elevated levels of serum nitrogenous substances, calcium, albumin, globulin, total protein along with altered renal calcium, oxalate and uric acid were also alleviated significantly followed by an improvement of the histopathological aberrancies. Phytochemical analysis showed evidence of phenolic components and flavonoids.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The current findings prove the beneficial role of phenolic and flavonoid rich EAFAL in ameliorating urolithiasis induced abnormalities of urine, serum and kidneys.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpp\/rgaa071","type":"journal-article","created":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T17:37:32Z","timestamp":1609868252000},"page":"560-572","source":"Crossref","is-referenced-by-count":13,"title":["Antiurolithic efficacy of a phenolic rich ethyl acetate fraction of the aerial parts of <i>Aerva lanata<\/i> (Linn) Juss. ex Schult. in ethylene glycol induced urolithic rats"],"prefix":"10.1093","volume":"73","author":[{"given":"Bitasta","family":"Mandal","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Technology, Adamas University , Barasat, Kolkata,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8404-7919","authenticated-orcid":false,"given":"Swati","family":"Madan","sequence":"additional","affiliation":[{"name":"Amity Institute of Pharmacy, Amity University , Noida, Uttar Pradesh,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayeed","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Bioactive Natural Product Laboratory, School of Pharmaceutical Education and Research, Jamia Hamdard, Hamdard University , New Delhi,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun K","family":"Sharma","sequence":"additional","affiliation":[{"name":"Amity University, Amity Education Valley Gurugram , Manesar, Panchgaon, Haryana,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Hafizur Rehman","family":"Ansari","sequence":"additional","affiliation":[{"name":"Bioactive Natural Product Laboratory, School of Pharmaceutical Education and Research, Jamia Hamdard, Hamdard University , New Delhi,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,4,1]]},"reference":[{"key":"2024103012055196600_CIT0001","doi-asserted-by":"crossref","first-page":"e5594","DOI":"10.1097\/MD.0000000000005594","article-title":"Associations between interventions for urolithiasis and urinary tract cancer among patients in Taiwan: The effect of early intervention","volume":"95","author":"Lin","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"2024103012055196600_CIT0002","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/S2222-1808(13)60107-3","article-title":"Pathophysiology of kidney, gall bladder and urinary stones treatment with herbal and allopathic medicine: A review","volume":"3","author":"Alok","year":"2013","journal-title":"Asian Pac J Trop Dis"},{"key":"2024103012055196600_CIT0003","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1475-2891-5-23","article-title":"Renal lithiasis and nutrition","volume":"5","author":"Grases","year":"2006","journal-title":"Nutr J"},{"key":"2024103012055196600_CIT0004","doi-asserted-by":"crossref","first-page":"292953","DOI":"10.1155\/2013\/292953","article-title":"Nephrolithiasis: molecular mechanism of renal stone formation and the critical role played by modulators","volume":"2013","author":"Aggarwal","year":"2013","journal-title":"Biomed Res Int"},{"key":"2024103012055196600_CIT0005","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1442-2042.2007.01953.x","article-title":"Mechanism of calcium oxalate renal stone formation and renal tubular cell injury","volume":"15","author":"Tsujihata","year":"2008","journal-title":"Int J Urol"},{"key":"2024103012055196600_CIT0006","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/B978-1-4160-3204-5.00048-7","article-title":"Urolithiasis in children.","volume-title":"Pediatric Urology","author":"Lottmann","year":"2010"},{"key":"2024103012055196600_CIT0007","first-page":"1935","article-title":"Herbal and allopathic medicine for kidney, gallbladder and urinary stones: A review","volume":"8","author":"Bijauliya","year":"2017","journal-title":"Int J Pharm Sci Res"},{"key":"2024103012055196600_CIT0008","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3923\/ajava.2016.9.16","article-title":"Urolithiasis: Critical analysis of mechanism of renal stone formation and use of medicinal plants as antiurolithiatic agents","volume":"11","author":"Panigrahi","year":"2016","journal-title":"Asian J Anim Vet Adv"},{"key":"2024103012055196600_CIT0009","first-page":"253","article-title":"A pharmacological review on gorakha ganja (Aerva lanata (Linn) Juss. ex. 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