{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T10:23:37Z","timestamp":1785752617182,"version":"3.56.0"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Jiangxi Province","award":["JXSYLXK-ZHYAO059"],"award-info":[{"award-number":["JXSYLXK-ZHYAO059"]}]},{"name":"Science and the Technology Plan of Jiangxi Health"},{"name":"Family Planning Commission","award":["20181140"],"award-info":[{"award-number":["20181140"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The current study was focused on preparing curcumin (CUR) supersaturated self-nano-emulsion (PI-CUR-SNEDDS) using hydrophilic polymer and to study the influence of polymer precipitation inhibitor on the physicochemical and biopharmaceutical properties of the PI-CUR-SNEDDS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>PI-CUR-SNEDDS were prepared using hydrophilic polymer in order to maintain the supersaturation of CUR in nano-emulsion solution, artificial gastrointestinal fluid (AGF), and the precipitates formed, and characterised by in vitro dispersion tests, in vitro intestinal absorption and in vivo pharmacokinetic and compared with CUR-SNEDDS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>PI-CUR-SNEDDS prepared with 2% hydroxypropyl methylcellulose 55\u201360 (HPMC55-60) as precipitation inhibitor (PI) significantly improved the viscosity, physical stability and CUR\u2019s equilibrium solubility of nanoemulsion. HPMC55-60 and CUR interact in AGF through intermolecular interactions, form hydrogen bonds, and produce amorphous precipitates. Compared with CUR-SNEDDS, the proportion of CUR in the hydrophilic phase increased by about 3-fold, and apparent permeability coefficient (Papp) in duodenum, jejunum, ileum, and colon increased by 2.30, 3.65, 1.54 and 2.08-fold, respectively, and the area under the plasma concentration-time curve0-12h of PI-CUR-SNEDDS also increased by 3.50-fold.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our results suggested that HPMC55-60 maintained the CUR supersaturation state by forming hydrogen bonds with CUR, increasing the solution\u2019s viscosity and drug solubilisation, thus improving the absorption and bioavailability of CUR.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpp\/rgaa073","type":"journal-article","created":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T20:35:24Z","timestamp":1609792524000},"page":"641-652","source":"Crossref","is-referenced-by-count":24,"title":["Improvement of the bioavailability of curcumin by a supersaturatable self nanoemulsifying drug delivery system with incorporation of a hydrophilic polymer: <i>in vitro<\/i> and <i>in vivo<\/i> characterisation"],"prefix":"10.1093","volume":"73","author":[{"given":"Xu-long","family":"Chen","sequence":"first","affiliation":[{"name":"Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Traditional Chinese Medicine , Nanchang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-li","family":"Liang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Traditional Chinese Medicine , Nanchang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-wei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Traditional Chinese Medicine , Nanchang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-yun","family":"Zeng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Traditional Chinese Medicine , Nanchang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Dong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Traditional Chinese Medicine , Nanchang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-quan","family":"Ou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Traditional Chinese Medicine , Nanchang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-nan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Traditional Chinese Medicine , Nanchang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qie-ying","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Traditional Chinese Medicine , Nanchang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3256-7549","authenticated-orcid":false,"given":"Zheng-gen","family":"Liao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Traditional Chinese Medicine , Nanchang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,5,1]]},"reference":[{"key":"2024103012060420900_CIT0001","first-page":"8","article-title":"Solubilization and protection of curcumin by mixed surfactants","volume":"54","author":"Liu","year":"2019","journal-title":"Acta Pharm Sin"},{"key":"2024103012060420900_CIT0002","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.foodchem.2015.12.077","article-title":"Enhanced solubilization of curcumin in mixed surfactant vesicles","volume":"199","author":"Kumar","year":"2016","journal-title":"Food Chem"},{"key":"2024103012060420900_CIT0003","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0378-5173(02)00323-X","article-title":"Studies of curcumin and curcuminoids. XXVII. Cyclodextrin complexation: solubility, chemical and photochemical stability","volume":"244","author":"T\u00f8nnesen","year":"2002","journal-title":"Int J Pharm"},{"key":"2024103012060420900_CIT0004","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s13318-019-00545-z","article-title":"Enhancing curcumin oral bioavailability through nanoformulations","volume":"44","author":"Ipar","year":"2019","journal-title":"Eur J Drug Metab Pharmacokinet"},{"key":"2024103012060420900_CIT0005","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/j.xphs.2019.11.019","article-title":"The preparation of curcumin sustained-release solid dispersion by hot melt extrusion. optimization of the formulation","volume":"109","author":"Fan","year":"2020","journal-title":"J Pharm Sci"},{"key":"2024103012060420900_CIT0006","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.3390\/molecules25092244","article-title":"Formulation, characterization and biological activity screening of sodium alginate-gum arabic nanoparticles loaded with curcumin","volume":"25","author":"Hassani","year":"2020","journal-title":"Molecules"},{"key":"2024103012060420900_CIT0007","doi-asserted-by":"crossref","first-page":"110853","DOI":"10.1016\/j.msec.2020.110853","article-title":"Curcumin and silver nanoparticles carried out from polysaccharide-based hydrogels improved the photodynamic properties of curcumin through metal-enhanced singlet oxygen effect","volume":"112","author":"de Freitas","year":"2020","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"2024103012060420900_CIT0008","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/jphp.12857","article-title":"Studies on the curcumin phospholipid complex solidified with soluplus\u00ae","volume":"70","author":"Wang","year":"2018","journal-title":"J Pharm Pharmacol"},{"key":"2024103012060420900_CIT0009","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.2147\/IJN.S200847","article-title":"Hybrid curcumin-phospholipid complex-near-infrared dye oral drug delivery system to inhibit lung metastasis of breast cancer","volume":"14","author":"Liu","year":"2019","journal-title":"Int J Nanomed"},{"key":"2024103012060420900_CIT0010","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1208\/s12249-020-01644-w","article-title":"Improved oral pharmacokinetics of pentoxifylline with palm oil and capmul\u00ae mcm containing self-nano-emulsifying drug delivery system","volume":"21","author":"Shailendrakumar","year":"2020","journal-title":"AAPS PharmSciTech"},{"key":"2024103012060420900_CIT0011","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.3390\/molecules25071703","article-title":"Bioactive self-nanoemulsifying drug delivery systems (bio-snedds) for combined oral delivery of curcumin and piperine","volume":"25","author":"Kazi","year":"2020","journal-title":"Molecules"},{"key":"2024103012060420900_CIT0012","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.addr.2016.04.007","article-title":"50years of oral lipid-based formulations: provenance, progress and future perspectives","volume":"101","author":"Feeney","year":"2016","journal-title":"Adv Drug Deliv Rev"},{"key":"2024103012060420900_CIT0013","first-page":"4091","article-title":"Preparation and in vitro quality evaluation of silybin supersaturated self-microemulsion drug delivery system","volume":"17","author":"Lai","year":"2019","journal-title":"Chin Tradit Herbal Drugs"},{"key":"2024103012060420900_CIT0014","doi-asserted-by":"crossref","first-page":"4982","DOI":"10.1002\/jps.22226","article-title":"Precipitation of a poorly soluble model drug during in vitro lipolysis: characterization and dissolution of the precipitate","volume":"99","author":"Sassene","year":"2010","journal-title":"J Pharm Sci"},{"key":"2024103012060420900_CIT0015","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1208\/s12248-014-9589-4","article-title":"In vitro lipolysis data does not adequately predict the in vivo performance of lipid-based drug delivery systems containing fenofibrate","volume":"16","author":"Thomas","year":"2014","journal-title":"Aaps J"},{"key":"2024103012060420900_CIT0016","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1007\/s11095-013-1038-z","article-title":"Toward the establishment of standardized in vitro tests for lipid-based formulations, part 3: understanding supersaturation versus precipitation potential during the in vitro digestion of type I, II, IIIA, IIIB and IV lipid-based formulations","volume":"30","author":"Williams","year":"2013","journal-title":"Pharm Res"},{"key":"2024103012060420900_CIT0017","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ejpb.2011.11.005","article-title":"Effects of solid carriers on the crystalline properties, dissolution and bioavailability of flurbiprofen in solid self-nanoemulsifying drug delivery system (solid snedds)","volume":"80","author":"Kang","year":"2012","journal-title":"Eur J Pharm Biopharm"},{"key":"2024103012060420900_CIT0018","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.ultsonch.2013.10.013","article-title":"Skin permeation of d-limonene-based nanoemulsions as a transdermal carrier prepared by ultrasonic emulsification","volume":"21","author":"Lu","year":"2014","journal-title":"Ultrason Sonochem"},{"key":"2024103012060420900_CIT0019","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1002\/jps.23054","article-title":"Influence of lipid composition and drug load on the in vitro performance of self-nanoemulsifying drug delivery systems","volume":"101","author":"Thomas","year":"2012","journal-title":"J pharm sci"},{"key":"2024103012060420900_CIT0020","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1002\/jps.21246","article-title":"Evaluation of the impact of surfactant digestion on the bioavailability of danazol after oral administration of lipidic self-emulsifying formulations to dogs","volume":"97","author":"Cuine","year":"2008","journal-title":"J Pharm Sci"},{"key":"2024103012060420900_CIT0021","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ejps.2004.08.003","article-title":"Solubilisation of poorly water-soluble drugs during in vitro lipolysis of medium- and long-chain triacylglycerols","volume":"23","author":"Christensen","year":"2004","journal-title":"Eur J Pharm Sci"},{"key":"2024103012060420900_CIT0022","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.ejpb.2010.04.009","article-title":"Combined use of ordered mesoporous silica and precipitation inhibitors for improved oral absorption of the poorly soluble weak base itraconazole","volume":"75","author":"Van Speybroeck","year":"2010","journal-title":"Eur J Pharm Biopharm"},{"key":"2024103012060420900_CIT0023","doi-asserted-by":"crossref","first-page":"475","DOI":"10.3109\/10837450.2012.710239","article-title":"Enhanced dissolution performance of curcumin with the use of supersaturatable formulations","volume":"18","author":"Gosangari","year":"2013","journal-title":"Pharm Dev Technol"},{"key":"2024103012060420900_CIT0024","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1021\/la503644m","article-title":"Impact of polymer conformation on the crystal growth inhibition of a poorly water-soluble drug in aqueous solution","volume":"31","author":"Schram","year":"2015","journal-title":"Langmuir"},{"key":"2024103012060420900_CIT0025","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1002\/jps.21451","article-title":"Characterization and optimization of AMG 517 supersaturatable self-emulsifying drug delivery system (S-SEDDS) for improved oral absorption","volume":"98","author":"Gao","year":"2009","journal-title":"J Pharm Sci"},{"key":"2024103012060420900_CIT0026","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3390\/polym9040124","article-title":"A polyvinylpyrrolidone-based supersaturable self-emulsifying drug delivery system for enhanced dissolution of cyclosporine A","volume":"9","author":"Lee","year":"2017","journal-title":"Polymers"},{"key":"2024103012060420900_CIT0027","first-page":"1115","article-title":"Improved oral bioavailability of poorly water-soluble indirubin by a supersaturatable self-microemulsifying drug delivery system","volume":"7","author":"Chen","year":"2012","journal-title":"Int J Nanomed"},{"key":"2024103012060420900_CIT0028","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1208\/s12248-016-9865-6","article-title":"Influence of copolymer composition on in vitro and in vivo performance of celecoxib-PVP\/VA amorphous solid dispersions","volume":"18","author":"Knopp","year":"2016","journal-title":"AAPS J"},{"key":"2024103012060420900_CIT0029","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ijpharm.2014.03.017","article-title":"Amorphous solid dispersion of berberine with absorption enhancer demonstrates a remarkable hypoglycemic effect via improving its bioavailability","volume":"467","author":"Meng","year":"2014","journal-title":"Int J Pharm"},{"key":"2024103012060420900_CIT0030","doi-asserted-by":"crossref","first-page":"675","DOI":"10.3109\/10717544.2014.896058","article-title":"Self-microemulsifying drug delivery system (SNEDDS)-challenges and road ahead","volume":"22","author":"Dokania","year":"2015","journal-title":"Drug Deliv"},{"key":"2024103012060420900_CIT0031","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.apsb.2015.07.003","article-title":"Insoluble drug delivery strategies: review of recent advances and business prospects","volume":"5","author":"Kalepu","year":"2015","journal-title":"Acta Pharm Sin B"},{"key":"2024103012060420900_CIT0032","doi-asserted-by":"crossref","first-page":"5352","DOI":"10.1021\/acs.jafc.8b00693","article-title":"Supersaturable selfemulsifying drug delivery system of krill oil with improved oral absorption and hypotriglyceridemic function","volume":"66","author":"Seto","year":"2018","journal-title":"J Agric Food Chem"},{"key":"2024103012060420900_CIT0033","first-page":"1109","article-title":"Enhanced dissolution and oral absorption of tacrolimus by supersaturable self-emulsifying drug delivery system","volume":"11","author":"Lee","year":"2016","journal-title":"Int J Nanomed"},{"key":"2024103012060420900_CIT0034","first-page":"1","article-title":"Characterization of self-emulsifying drug delivery systems using in situ raman spectroscopy to study the precipitation inhibition mechanism of poorly water-soluble drugs","volume":"1","author":"Raut","year":"2018","journal-title":"J Pharm Innov"},{"key":"2024103012060420900_CIT0035","first-page":"3672","article-title":"Preparation and in vitro quality evaluation of curcumin supersaturated self-nanoemulsion","volume":"45","author":"Chen","year":"2020","journal-title":"Chin J Chin Mater Med"},{"key":"2024103012060420900_CIT0036","first-page":"154","article-title":"Investigation on correlation of phase behavior and stability of curcumin self-nanoemulsion with different drug loading after in vitro dispersion","volume":"27","author":"Chen","year":"2020","journal-title":"Chin J Exp Tradit Med Form"},{"key":"2024103012060420900_CIT0037","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s11596-017-1742-8","article-title":"Therapeutic effects of curcumin nanoemulsions on prostate cancer","volume":"37","author":"Guan","year":"2017","journal-title":"J Huazhong Univ Sci Technol"},{"key":"2024103012060420900_CIT0038","doi-asserted-by":"crossref","first-page":"520","DOI":"10.2174\/1567201814666171120121217","article-title":"Preferential formulation of second generation antipsychotic a senapine as inclusion complex with sulphobutylether-betaCD (captisol): in vitro and in vivo evaluation","volume":"15","author":"Kulkarni","year":"2018","journal-title":"Curr Drug Deliv"},{"key":"2024103012060420900_CIT0039","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.carbpol.2018.02.010","article-title":"Improving the stability of thyme essential oil solid liposome by using beta-cyclodextrin as a cryoprotectant","volume":"188","author":"Lin","year":"2018","journal-title":"Carbohydr Polym"},{"key":"2024103012060420900_CIT0040","first-page":"4928","article-title":"Effect of radix astragali and aconiti lateralis radix preparata on intestinal absorption of six kinds of alkaloids in aconiti lateralis radix preparata","volume":"48","author":"Kong","year":"2017","journal-title":"Chin Tradit Herbal Drugs"},{"key":"2024103012060420900_CIT0041","first-page":"60","article-title":"Enhanced solubility and anticancer efficacy of curcumin by reduction-sensitive chondroitin sulfate a-ss-deoxycholic acid micelles","volume":"37","author":"Wu","year":"2018","journal-title":"Lat Am J Pharm"},{"key":"2024103012060420900_CIT0042","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.ijpharm.2017.06.017","article-title":"Self-micellizing solid dispersions enhance the properties and therapeutic potential of fenofibrate: advantages, profiles and mechanisms","volume":"528","author":"Shi","year":"2017","journal-title":"Int J pharmaceut"},{"key":"2024103012060420900_CIT0043","first-page":"462","article-title":"Rules and characteristics of crystallization inhibition of cellulose polymers against drugs in supersaturated states","volume":"51","author":"Shi","year":"2016","journal-title":"Acta pharm Sin"},{"key":"2024103012060420900_CIT0044","first-page":"3509","article-title":"Self-assembled nanoparticles based on the c(RGDfk) peptide for the delivery of siRNA targeting the VEGFR2 gene for tumor therapy","volume":"9","author":"Liu","year":"2014","journal-title":"Int J Nanomed"},{"key":"2024103012060420900_CIT0045","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1080\/15685551.2020.1804183","article-title":"Polyvinyl alcohol\/sodium alginate hydrogels incorporated with silver nanoclusters via green tea extract for antibacterial applications","volume":"23","author":"Wang","year":"2020","journal-title":"Des Monomers Polym"},{"key":"2024103012060420900_CIT0046","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1186\/s11671-017-2256-9","article-title":"Effects of micro-environmental pH of liposome on chemical stability of loaded drug","volume":"12","author":"Shao","year":"2017","journal-title":"Nanoscale Res Lett"},{"key":"2024103012060420900_CIT0047","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.2147\/IJN.S204550","article-title":"Formulation and characterization of chlorhexidine hcl nanoemulsion as a promising antibacterial root canal irrigant: in-vitro and ex-vivo studies","volume":"14","author":"Abdelmonem","year":"2019","journal-title":"Int J Nanomed"},{"key":"2024103012060420900_CIT0048","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.2147\/DDDT.S106356","article-title":"Design and optimization of self-nanoemulsifying drug delivery systems for improved bioavailability of cyclovirobuxine D","volume":"10","author":"Ke","year":"2016","journal-title":"Drug Des Devel Ther"},{"key":"2024103012060420900_CIT0049","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1021\/mp800142z","article-title":"Effects of polymer additives on the crystallization of hydrates: a molecular-level modulation","volume":"6","author":"Tian","year":"2009","journal-title":"Mol Pharm"},{"key":"2024103012060420900_CIT0050","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.3390\/molecules25122791","article-title":"Formulation of more efficacious curcumin delivery systems using colloid science: enhanced solubility, stability, and bioavailability","volume":"25","author":"Zheng","year":"2020","journal-title":"Molecules"},{"key":"2024103012060420900_CIT0051","doi-asserted-by":"crossref","first-page":"236","DOI":"10.3390\/mi7120236","article-title":"Microfluidic fabrication of hydrocortisone nanocrystals coated with polymeric stabilisers","volume":"7","author":"Odetade","year":"2016","journal-title":"Micromachines (Basel)"},{"key":"2024103012060420900_CIT0052","doi-asserted-by":"crossref","first-page":"105035","DOI":"10.1016\/j.ejps.2019.105035","article-title":"Enhancing the physical stability and supersaturation generation of amorphous drug-polyelectrolyte nanoparticle complex via incorporation of crystallization inhibitor at the nanoparticle formation step: a case of HPMC versus PVP","volume":"138","author":"Dong","year":"2019","journal-title":"Eur J Pharm Sci"},{"key":"2024103012060420900_CIT0053","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.3390\/molecules21101386","article-title":"Characterization, in vivo and in vitro evaluation of solid dispersion of curcumin containing d-\u0251-tocopheryl polyethylene glycol 1000 succinate and mannitol","volume":"21","author":"Song","year":"2016","journal-title":"Molecules"},{"key":"2024103012060420900_CIT0054","first-page":"140","article-title":"Relation between drug release and the drug status within curcumin-loaded microsphere","volume":"51","author":"Chen","year":"2016","journal-title":"Acta Pharm Sin"},{"key":"2024103012060420900_CIT0055","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0378-5173(00)00610-4","article-title":"Crystallization of hydrocortisone acetate: influence of polymers","volume":"212","author":"Raghavan","year":"2001","journal-title":"Int J Pharm"},{"key":"2024103012060420900_CIT0056","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jconrel.2012.02.027","article-title":"In vitro and in vivo performance of novel supersaturated self-nanoemulsifying drug delivery systems (super-SNEDDS)","volume":"160","author":"Thomas","year":"2012","journal-title":"J Control Release"},{"key":"2024103012060420900_CIT0057","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1021\/js950472p","article-title":"A physicochemical basis for the effect of food on the absolute oral bioavailability of halofantrine","volume":"85","author":"Humberstone","year":"1996","journal-title":"J Pharm Sci"}],"container-title":["Journal of Pharmacy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/73\/5\/641\/60217881\/rgaa073.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/73\/5\/641\/60217881\/rgaa073.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T16:47:59Z","timestamp":1730306879000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpp\/article\/73\/5\/641\/6144892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,1]]},"references-count":57,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,5,1]]},"published-print":{"date-parts":[[2021,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jpp\/rgaa073","relation":{},"ISSN":["0022-3573","2042-7158"],"issn-type":[{"value":"0022-3573","type":"print"},{"value":"2042-7158","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,5,1]]},"published":{"date-parts":[[2021,5,1]]}}}