{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T17:47:14Z","timestamp":1772819234470,"version":"3.50.1"},"reference-count":78,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Al Jalila Foundation, United Arab Emirates","award":["AJF2018050"],"award-info":[{"award-number":["AJF2018050"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Cancer is a leading cause of disabling morbidities and death worldwide. Although there are various strategies for the management of cancer, the severe adverse effects negatively impact the patient\u2019s quality of life. In addition, the development of resistance limits the efficacy of many chemotherapeutics. Many natural agents are capable of reducing the adverse effects associated with chemotherapy and improving the therapeutic outcome. Tangeretin, a polymethoxy flavone, is one of the promising natural anticancer agents.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>Tangeretin not only targets various malignancies but also synergizes chemotherapeutic agents and reverses cancer resistance. Hence, the application of tangeretin as an adjuvant in cancer chemotherapy would be a promising strategy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>This work critically highlighted the proposed anticancer activity of tangeretin and discussed its potential combination with various chemotherapeutic agents. Additionally, it shed light on tangeretin chemical derivatives with improved pharmacokinetic and pharmacodynamic activity. Finally, this review described flavonoid biosynthetic pathways and how bioengineering can be employed to enhance the production yield of tangeretin. Thus, this work paves the way for the rational clinical utilization of tangeretin as a safe and effective adjuvant in chemotherapeutic protocols.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpp\/rgab013","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T12:51:07Z","timestamp":1610974267000},"page":"601-610","source":"Crossref","is-referenced-by-count":13,"title":["Tangeretin as an adjuvant and chemotherapeutic sensitizer against various types of cancers: a comparative overview"],"prefix":"10.1093","volume":"73","author":[{"given":"Dima W","family":"Alhamad","sequence":"first","affiliation":[{"name":"College of Pharmacy, University of Sharjah , Sharjah,","place":["United Arab Emirates"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara M","family":"Elgendy","sequence":"additional","affiliation":[{"name":"College of Pharmacy, University of Sharjah , Sharjah,","place":["United Arab Emirates"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taleb H","family":"Al-Tel","sequence":"additional","affiliation":[{"name":"College of Pharmacy, University of Sharjah , Sharjah,","place":["United Arab Emirates"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4670-8149","authenticated-orcid":false,"given":"Hany A","family":"Omar","sequence":"additional","affiliation":[{"name":"College of Pharmacy, University of Sharjah , Sharjah,","place":["United Arab Emirates"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,5,1]]},"reference":[{"key":"2024103012060009200_CIT0001","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21551","article-title":"Cancer statistics, 2019","volume":"69","author":"Siegel","year":"2019","journal-title":"CA Cancer J Clin"},{"key":"2024103012060009200_CIT0002","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/nrclinonc.2013.158","article-title":"Drug rechallenge and treatment beyond progression-implications for drug resistance","volume":"10","author":"Kuczynski","year":"2013","journal-title":"Nat Rev Clin Oncol"},{"key":"2024103012060009200_CIT0003","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/sj.bjc.6600775","article-title":"Vegetables and fruit intake and cancer mortality in the Hiroshima\/Nagasaki Life Span Study","volume":"88","author":"Sauvaget","year":"2003","journal-title":"Br J Cancer"},{"key":"2024103012060009200_CIT0004","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1158\/1055-9965.EPI-07-2665","article-title":"Vegetables and fruits in relation to cancer risk: evidence from the Greek EPIC cohort study","volume":"17","author":"Benetou","year":"2008","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2024103012060009200_CIT0005","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/aje\/kwm263","article-title":"Fruit and vegetable intake and risk of total cancer and cardiovascular disease: Japan Public Health Center-Based Prospective Study","volume":"167","author":"Takachi","year":"2008","journal-title":"Am J Epidemiol"},{"key":"2024103012060009200_CIT0006","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.amjmed.2006.03.045","article-title":"Fruit and vegetable juices and Alzheimer\u2019s disease: the Kame Project","volume":"119","author":"Dai","year":"2006","journal-title":"Am J Med"},{"key":"2024103012060009200_CIT0007","doi-asserted-by":"crossref","first-page":"780","DOI":"10.3389\/fphar.2018.00780","article-title":"Enhancing the Anticancer Activity of Antrodia cinnamomea in Hepatocellular Carcinoma Cells via Cocultivation With Ginger: The Impact on Cancer Cell Survival Pathways","volume":"9","author":"Chen","year":"2018","journal-title":"Front Pharmacol"},{"key":"2024103012060009200_CIT0008","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s10555-012-9347-y","article-title":"Flavonoids, a ubiquitous dietary phenolic subclass, exert extensive in vitro anti-invasive and in vivo anti-metastatic activities","volume":"31","author":"Weng","year":"2012","journal-title":"Cancer Metastasis Rev"},{"key":"2024103012060009200_CIT0009","doi-asserted-by":"crossref","first-page":"8203","DOI":"10.1002\/jcp.27628","article-title":"Leukemia therapy by flavonoids: Future and involved mechanisms","volume":"234","author":"Saraei","year":"2019","journal-title":"J Cell Physiol"},{"key":"2024103012060009200_CIT0010","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1021\/jf1033224","article-title":"Pharmacokinetic study of nobiletin and tangeretin in rat serum by high-performance liquid chromatography-electrospray ionization-mass spectrometry","volume":"59","author":"Manthey","year":"2011","journal-title":"J Agric Food Chem"},{"key":"2024103012060009200_CIT0011","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.1097\/00001756-200112040-00053","article-title":"Tissue distribution and neuroprotective effects of citrus flavonoid tangeretin in a rat model of Parkinson\u2019s disease","volume":"12","author":"Datla","year":"2001","journal-title":"Neuroreport"},{"key":"2024103012060009200_CIT0012","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.intimp.2014.01.011","article-title":"Tangeretin exerts anti-neuroinflammatory effects via NF-\u03baB modulation in lipopolysaccharide-stimulated microglial cells","volume":"19","author":"Shu","year":"2014","journal-title":"Int Immunopharmacol"},{"key":"2024103012060009200_CIT0013","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.phymed.2014.01.007","article-title":"Effect of tangeretin, a polymethoxylated flavone on glucose metabolism in streptozotocin-induced diabetic rats","volume":"21","author":"Sundaram","year":"2014","journal-title":"Phytomedicine"},{"key":"2024103012060009200_CIT0014","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1016\/j.foodchem.2011.12.021","article-title":"Antimicrobial activity of nobiletin and tangeretin against Pseudomonas","volume":"132","author":"Yao","year":"2012","journal-title":"Food Chem"},{"key":"2024103012060009200_CIT0015","doi-asserted-by":"crossref","first-page":"111529","DOI":"10.1016\/j.fct.2020.111529","article-title":"Synergistic therapy with tangeretin and 5-fluorouracil accelerates the ROS\/JNK mediated apoptotic pathway in human colorectal cancer cell","volume":"143","author":"Dey","year":"2020","journal-title":"Food Chem Toxicol"},{"key":"2024103012060009200_CIT0016","first-page":"103","article-title":"A safety study of oral tangeretin and xanthohumol administration to laboratory mice","volume":"19","author":"Vanhoecke","year":"2005","journal-title":"In Vivo"},{"key":"2024103012060009200_CIT0017","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.jfda.2017.08.003","article-title":"Pharmacokinetics, bioavailability, tissue distribution and excretion of tangeretin in rat","volume":"26","author":"Hung","year":"2018","journal-title":"J Food Drug Anal"},{"key":"2024103012060009200_CIT0018","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1021\/bk-2008-0987.ch016","article-title":"Bioavailability of Polymethoxyflavones","volume":"987","author":"Li","year":"2008","journal-title":"ACS Symposium Series"},{"key":"2024103012060009200_CIT0019","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.foodres.2015.04.031","article-title":"Safety evaluation of tangeretin and the effect of using emulsion-based delivery system: Oral acute and 28-day sub-acute toxicity study using mice","volume":"74","author":"Ting","year":"2015","journal-title":"Food Res Int"},{"key":"2024103012060009200_CIT0020","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.biochi.2013.11.017","article-title":"Chemotherapeutic effect of tangeretin, a polymethoxylated flavone studied in 7,-12-dimethylbenz(a)anthracene induced mammary carcinoma in experimental rats","volume":"99","author":"Lakshmi","year":"2014","journal-title":"Biochimie"},{"key":"2024103012060009200_CIT0021","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1002\/mnfr.200900186","article-title":"The flavonoid tangeretin activates the unfolded protein response and synergizes with imatinib in the erythroleukemia cell line K562","volume":"54","author":"Lust","year":"2010","journal-title":"Mol Nutr Food Res"},{"key":"2024103012060009200_CIT0022","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.canlet.2006.11.016","article-title":"Tangeretin and nobiletin induce G1 cell cycle arrest but not apoptosis in human breast and colon cancer cells","volume":"251","author":"Morley","year":"2007","journal-title":"Cancer Lett"},{"key":"2024103012060009200_CIT0023","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1038\/bjc.1995.518","article-title":"Citrus flavone tangeretin inhibits leukaemic HL-60 cell growth partially through induction of apoptosis with less cytotoxicity on normal lymphocytes","volume":"72","author":"Hirano","year":"1995","journal-title":"Br J Cancer"},{"key":"2024103012060009200_CIT0024","doi-asserted-by":"crossref","first-page":"8910","DOI":"10.1158\/0008-5472.CAN-09-1543","article-title":"Tangeretin sensitizes cisplatin-resistant human ovarian cancer cells through downregulation of phosphoinositide 3-kinase\/Akt signaling pathway","volume":"69","author":"Arafa","year":"2009","journal-title":"Cancer Res"},{"key":"2024103012060009200_CIT0025","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0098-2997(00)00007-8","article-title":"The molecular biology of cancer","volume":"21","author":"Bertram","year":"2000","journal-title":"Mol Aspects Med"},{"key":"2024103012060009200_CIT0026","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/978-1-4757-5235-9_12","article-title":"The citrus methoxyflavone tangeretin affects human cell-cell interactions","volume":"505","author":"Brack","year":"2002","journal-title":"Adv Exp Med Biol"},{"key":"2024103012060009200_CIT0027","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1016\/j.febslet.2004.10.114","article-title":"Tangeretin inhibits extracellular-signal-regulated kinase (ERK) phosphorylation","volume":"579","author":"Van Slambrouck","year":"2005","journal-title":"FEBS Lett"},{"key":"2024103012060009200_CIT0028","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.tiv.2018.04.001","article-title":"Tangeretin inhibits the proliferation of human breast cancer cells via CYP1A1\/CYP1B1 enzyme induction and CYP1A1\/CYP1B1-mediated metabolism to the product 4\u2019 hydroxy tangeretin","volume":"50","author":"Surichan","year":"2018","journal-title":"Toxicol In Vitro"},{"key":"2024103012060009200_CIT0029","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s00280-014-2629-z","article-title":"Antitumor efficacy of tangeretin by targeting the oxidative stress mediated on 7,12-dimethylbenz(a) anthracene-induced proliferative breast cancer in Sprague-Dawley rats","volume":"75","author":"Periyasamy","year":"2015","journal-title":"Cancer Chemother Pharmacol"},{"key":"2024103012060009200_CIT0030","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/j.jnutbio.2014.06.007","article-title":"Tangeretin, a citrus pentamethoxyflavone, exerts cytostatic effect via p53\/p21 up-regulation and suppresses metastasis in 7,12-dimethylbenz(\u03b1)anthracene-induced rat mammary carcinoma","volume":"25","author":"Arivazhagan","year":"2014","journal-title":"J Nutr Biochem"},{"key":"2024103012060009200_CIT0031","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1093\/carcin\/23.10.1677","article-title":"Tangeretin induces cell-cycle G1 arrest through inhibiting cyclin-dependent kinases 2 and 4 activities as well as elevating Cdk inhibitors p21 and p27 in human colorectal carcinoma cells","volume":"23","author":"Pan","year":"2002","journal-title":"Carcinogenesis"},{"key":"2024103012060009200_CIT0032","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1634\/theoncologist.7-5-401","article-title":"Clinical trial design for target-based therapy","volume":"7","author":"Fox","year":"2002","journal-title":"Oncologist"},{"key":"2024103012060009200_CIT0033","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.jff.2015.03.034","article-title":"In vitro and in vivo anti-cancer activity of tangeretin against colorectal cancer was enhanced by emulsion-based delivery system","volume":"15","author":"Ting","year":"2015","journal-title":"J Funct Foods"},{"key":"2024103012060009200_CIT0034","doi-asserted-by":"crossref","first-page":"17036","DOI":"10.1038\/nrdp.2017.36","article-title":"Gastric adenocarcinoma","volume":"3","author":"Ajani","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"2024103012060009200_CIT0035","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1038\/bjc.2015.25","article-title":"Dietary intake of flavonoids and oesophageal and gastric cancer: incidence and survival in the United States of America (USA)","volume":"112","author":"Petrick","year":"2015","journal-title":"Br J Cancer"},{"key":"2024103012060009200_CIT0036","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.3892\/or.2014.3034","article-title":"Tangeretin, a citrus polymethoxyflavonoid, induces apoptosis of human gastric cancer AGS cells through extrinsic and intrinsic signaling pathways","volume":"31","author":"Dong","year":"2014","journal-title":"Oncol Rep"},{"key":"2024103012060009200_CIT0037","first-page":"3249","article-title":"Identification of a novel biomarker in tangeretin-induced cell death in AGS human gastric cancer cells","volume":"40","author":"Yumnam","year":"2018","journal-title":"Oncol Rep"},{"key":"2024103012060009200_CIT0038","doi-asserted-by":"crossref","first-page":"302","DOI":"10.3892\/or.2015.3982","article-title":"Tangeretin enhances radiosensitivity and inhibits the radiation-induced epithelial-mesenchymal transition of gastric cancer cells","volume":"34","author":"Zhang","year":"2015","journal-title":"Oncol Rep"},{"key":"2024103012060009200_CIT0039","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/0024-3205(94)00641-5","article-title":"Natural flavonoids and lignans are potent cytostatic agents against human leukemic HL-60 cells","volume":"55","author":"Hirano","year":"1994","journal-title":"Life Sci"},{"key":"2024103012060009200_CIT0040","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3109\/07357900902744486","article-title":"Effects of naturally occurring polymethyoxyflavonoids on cell growth, P-glycoprotein function, cell cycle, and apoptosis of daunorubicin-resistant T lymphoblastoid leukemia cells","volume":"28","author":"Ishii","year":"2010","journal-title":"Cancer Invest"},{"key":"2024103012060009200_CIT0041","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1271\/bbb.63.896","article-title":"Antiproliferative activity of flavonoids on several cancer cell lines","volume":"63","author":"Kawaii","year":"1999","journal-title":"Biosci Biotechnol Biochem"},{"key":"2024103012060009200_CIT0042","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3322\/caac.21565","article-title":"Cancer treatment and survivorship statistics, 2019","volume":"69","author":"Miller","year":"2019","journal-title":"CA Cancer J Clin"},{"key":"2024103012060009200_CIT0043","first-page":"433","article-title":"Dietary flavonoid tangeretin induces reprogramming of epithelial to mesenchymal transition in prostate cancer cells by targeting the PI3K\/Akt\/mTOR signaling pathway","volume":"15","author":"Zhu","year":"2018","journal-title":"Oncol Lett"},{"key":"2024103012060009200_CIT0044","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.bcp.2006.09.018","article-title":"Tangeretin suppresses IL-1\u03b2-induced cyclooxygenase (COX)-2 expression through inhibition of p38 MAPK, JNK, and AKT activation in human lung carcinoma cells","volume":"73","author":"Chen","year":"2007","journal-title":"Biochem Pharmacol"},{"key":"2024103012060009200_CIT0045","doi-asserted-by":"crossref","first-page":"6791","DOI":"10.1021\/jf058050g","article-title":"Treatment of metastatic melanoma B16F10 by the flavonoids tangeretin, rutin, and diosmin","volume":"53","author":"Martinez Conesa","year":"2005","journal-title":"J Agric Food Chem"},{"key":"2024103012060009200_CIT0046","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0304-3835(91)90089-Z","article-title":"Antiproliferative effects of citrus flavonoids on a human squamous cell carcinoma in vitro","volume":"56","author":"Kandaswami","year":"1991","journal-title":"Cancer Lett"},{"key":"2024103012060009200_CIT0047","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.cbi.2016.09.008","article-title":"Tangeretin attenuates cisplatin-induced renal injury in rats: impact on the inflammatory cascade and oxidative perturbations","volume":"258","author":"Arab","year":"2016","journal-title":"Chem Biol Interact"},{"key":"2024103012060009200_CIT0048","doi-asserted-by":"crossref","first-page":"e0151649","DOI":"10.1371\/journal.pone.0151649","article-title":"Tangeretin alleviates cisplatin-induced acute hepatic injury in rats: Targeting MAPKs and Apoptosis","volume":"11","author":"Omar","year":"2016","journal-title":"PLoS One"},{"key":"2024103012060009200_CIT0049","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.phrs.2016.04.003","article-title":"Tangeretin, a citrus pentamethoxyflavone, antagonizes ABCB1-mediated multidrug resistance by inhibiting its transport function","volume":"110","author":"Feng","year":"2016","journal-title":"Pharmacol Res"},{"key":"2024103012060009200_CIT0050","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1007\/s11095-007-9320-6","article-title":"Effects of various methoxyflavones on vincristine uptake and multidrug resistance to vincristine in P-gp-overexpressing K562\/ADM cells","volume":"24","author":"Ohtani","year":"2007","journal-title":"Pharm Res"},{"key":"2024103012060009200_CIT0051","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1093\/jnci\/91.4.354","article-title":"Influence of tangeretin on tamoxifen\u2019s therapeutic benefit in mammary cancer","volume":"91","author":"Bracke","year":"1999","journal-title":"J Natl Cancer Inst"},{"key":"2024103012060009200_CIT0052","first-page":"230","article-title":"Polymethoxylated flavones in orange juice are inhibitors of P-glycoprotein but not cytochrome P450 3A4","volume":"293","author":"Takanaga","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"key":"2024103012060009200_CIT0053","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/sj.bjp.0706008","article-title":"Effects of grapefruit juice and orange juice components on P-glycoprotein- and MRP2-mediated drug efflux","volume":"143","author":"Honda","year":"2004","journal-title":"Br J Pharmacol"},{"key":"2024103012060009200_CIT0054","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0304-3835(00)00549-8","article-title":"Inhibition of P-glycoprotein by orange juice components, polymethoxyflavones in adriamycin-resistant human myelogenous leukemia (K562\/ADM) cells","volume":"160","author":"Ikegawa","year":"2000","journal-title":"Cancer Lett"},{"key":"2024103012060009200_CIT0055","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1182\/blood.V104.11.2093.2093","article-title":"Tangeretin synergizes with imatinib in inhibiting growth of Bcr-Abl positive K562 erythroleukemia cells in an Erk-dependent way","volume":"104","author":"Lust","year":"2004","journal-title":"Blood"},{"key":"2024103012060009200_CIT0056","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1002\/mnfr.201300136","article-title":"5-Demethyltangeretin inhibits human nonsmall cell lung cancer cell growth by inducing G2\/M cell cycle arrest and apoptosis","volume":"57","author":"Charoensinphon","year":"2013","journal-title":"Mol Nutr Food Res"},{"key":"2024103012060009200_CIT0057","doi-asserted-by":"crossref","first-page":"119134","DOI":"10.1016\/j.ijpharm.2020.119134","article-title":"Preparation and evaluation of self-microemulsifying delivery system containing 5-demethyltangeretin on inhibiting xenograft tumor growth in mice","volume":"579","author":"Chou","year":"2020","journal-title":"Int J Pharm"},{"key":"2024103012060009200_CIT0058","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1016\/j.bmc.2007.03.021","article-title":"Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines","volume":"15","author":"Li","year":"2007","journal-title":"Bioorg Med Chem"},{"key":"2024103012060009200_CIT0059","doi-asserted-by":"crossref","first-page":"S244","DOI":"10.1002\/mnfr.200900605","article-title":"Inhibitory effects of 5-hydroxy polymethoxyflavones on colon cancer cells","volume":"54","author":"Qiu","year":"2010","journal-title":"Mol Nutr Food Res"},{"key":"2024103012060009200_CIT0060","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/mnfr.201000269","article-title":"The p53-, Bax- and p21-dependent inhibition of colon cancer cell growth by 5-hydroxy polymethoxyflavones","volume":"55","author":"Qiu","year":"2011","journal-title":"Mol Nutr & Food Res"},{"key":"2024103012060009200_CIT0061","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.jff.2014.08.009","article-title":"5-Demethyltangeretin is more potent than tangeretin in inhibiting dimethylbenz(a)anthracene (DMBA)\/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin tumorigenesis","volume":"11","author":"Ma","year":"2014","journal-title":"J Funct Foods"},{"key":"2024103012060009200_CIT0062","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1007\/s12013-014-0049-7","article-title":"Pro-apoptotic effects of the novel tangeretin derivate 5-acetyl-6,7,8,4\u2019-tetramethylnortangeretin on MCF-7 breast cancer cells","volume":"70","author":"Wang","year":"2014","journal-title":"Cell Biochem Biophys"},{"key":"2024103012060009200_CIT0063","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.fshw.2014.12.003","article-title":"5-Acetyl-6,7,8,4\u2032-tetramethylnortangeretin induces apoptosis in multiple myeloma U266 cells","volume":"3","author":"Zhi","year":"2014","journal-title":"Food Sci Hum Well"},{"key":"2024103012060009200_CIT0064","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1080\/15384047.2015.1108491","article-title":"Tangeretin derivative, 5-acetyloxy-6,7,8,4\u2019-tetramethoxyflavone induces G2\/M arrest, apoptosis and autophagy in human non-small cell lung cancer cells in vitro and in vivo","volume":"17","author":"Li","year":"2016","journal-title":"Cancer Biol Ther"},{"key":"2024103012060009200_CIT0065","doi-asserted-by":"crossref","first-page":"3366","DOI":"10.3390\/ijms20133366","article-title":"Blockade of STAT3 Signaling Contributes to Anticancer Effect of 5-acetyloxy-6,7,8,4\u2019-tetra-methoxyflavone, a tangeretin derivative, on human glioblastoma multiforme cells","volume":"20","author":"Cheng","year":"2019","journal-title":"Int J Mol Sci"},{"key":"2024103012060009200_CIT0066","first-page":"30","article-title":"lavonoid functions in plants and their interactions with other organisms","volume":"7","author":"Mathesius","year":"2018","journal-title":"Plants (Basel)"},{"key":"2024103012060009200_CIT0067","first-page":"27","article-title":"Flavones: from biosynthesis to health benefits","volume":"5","author":"Jiang","year":"2016","journal-title":"Plants (Basel)"},{"key":"2024103012060009200_CIT0068","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1080\/10408398.2018.1544885","article-title":"Biosynthesis of citrus flavonoids and their health effects","volume":"60","author":"Zhao","year":"2020","journal-title":"Crit Rev Food Sci Nutr"},{"key":"2024103012060009200_CIT0069","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1016\/j.phytochem.2005.07.013","article-title":"Flavones and flavone synthases","volume":"66","author":"Martens","year":"2005","journal-title":"Phytochemistry"},{"key":"2024103012060009200_CIT0070","doi-asserted-by":"crossref","first-page":"225","DOI":"10.2503\/hortj.UTD-146","article-title":"Accumulation of polymethoxyflavones and O-methyltransferase gene expression in various citrus cultivars","volume":"89","author":"Tuz Zohra","year":"2020","journal-title":"Hort J"},{"key":"2024103012060009200_CIT0071","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1002\/biot.200700184","article-title":"Biotechnology of flavonoids and other phenylpropanoid-derived natural products. Part II: reconstruction of multienzyme pathways in plants and microbes","volume":"2","author":"Ververidis","year":"2007","journal-title":"Biotechnol J"},{"key":"2024103012060009200_CIT0072","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.ymben.2009.07.004","article-title":"Metabolic engineering of the complete pathway leading to heterologous biosynthesis of various flavonoids and stilbenoids in Saccharomyces cerevisiae","volume":"11","author":"Trantas","year":"2009","journal-title":"Metab Eng"},{"key":"2024103012060009200_CIT0073","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3389\/fpls.2015.00007","article-title":"When plants produce not enough or at all: metabolic engineering of flavonoids in microbial hosts","volume":"6","author":"Trantas","year":"2015","journal-title":"Front Plant Sci"},{"key":"2024103012060009200_CIT0074","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/1475-2859-11-155","article-title":"De novo production of the flavonoid naringenin in engineered Saccharomyces cerevisiae","volume":"11","author":"Koopman","year":"2012","journal-title":"Microb Cell Fact"},{"key":"2024103012060009200_CIT0075","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00253-005-0116-5","article-title":"Combinatorial biosynthesis of flavones and flavonols in Escherichia coli","volume":"71","author":"Miyahisa","year":"2006","journal-title":"Appl Microbiol Biotechnol"},{"key":"2024103012060009200_CIT0076","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.chembiol.2007.05.004","article-title":"Synthesis of unnatural flavonoids and stilbenes by exploiting the plant biosynthetic pathway in Escherichia coli","volume":"14","author":"Katsuyama","year":"2007","journal-title":"Chem Biol"},{"key":"2024103012060009200_CIT0077","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1186\/s12870-016-0870-9","article-title":"Molecular cloning and characterization of a flavonoid-O-methyltransferase with broad substrate specificity and regioselectivity from Citrus depressa","volume":"16","author":"Itoh","year":"2016","journal-title":"BMC Plant Biol"},{"key":"2024103012060009200_CIT0078","doi-asserted-by":"crossref","first-page":"3066","DOI":"10.1093\/jxb\/eraa083","article-title":"Characterization of a caffeoyl-CoA O-methyltransferase-like enzyme involved in biosynthesis of polymethoxylated flavones in Citrus reticulata","volume":"71","author":"Liu","year":"2020","journal-title":"J Exp Bot"}],"container-title":["Journal of Pharmacy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/73\/5\/601\/60217081\/rgab013.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/73\/5\/601\/60217081\/rgab013.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T16:47:27Z","timestamp":1730306847000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpp\/article\/73\/5\/601\/6158537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,1]]},"references-count":78,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,5,1]]},"published-print":{"date-parts":[[2021,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jpp\/rgab013","relation":{},"ISSN":["0022-3573","2042-7158"],"issn-type":[{"value":"0022-3573","type":"print"},{"value":"2042-7158","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,5,1]]},"published":{"date-parts":[[2021,5,1]]}}}