{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:13:44Z","timestamp":1790792024972,"version":"4.1.0"},"reference-count":118,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773941"],"award-info":[{"award-number":["81773941"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key Subject of Drug Innovation","award":["2019ZX09201005-007"],"award-info":[{"award-number":["2019ZX09201005-007"]}]},{"name":"National key R & D program for key research project of modernization of traditional Chinese medicine","award":["2019YFC1711602"],"award-info":[{"award-number":["2019YFC1711602"]}]},{"name":"Xinglin Scholar Discipline Promotion Talent Program of Chengdu University of Traditional Chinese Medicine","award":["BSH2018006"],"award-info":[{"award-number":["BSH2018006"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Isatis indigotica Fort. (I. indigotica) is an herbaceous plant belonging to Cruciferae family. Its leaf (IIL) and root (IIR) are commonly used in traditional Chinese medicines (TCMs) with good clinical efficacies such as clearing away heat and detoxification, cooling blood and reducing swelling. This review aimed to provide a systematic summary on the phytochemistry, pharmacology and clinical applications of I. indigotica.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>This plant contains alkaloids, organic acids, flavonoids, lignans, nucleosides, amino acids, and steroids. Previous pharmacological researches indicated that I. indigotica possesses promising antivirus, antibacterial, immunoregulatory, anti-inflammation, and cholagogic effects. Importantly, it can inhibit various viruses, such as influenza, hepatitis B, mumps, herpes simplex, cytomegalovirus, and coxsachievirus. Clinically, it is frequently used to treat various viral diseases like viral influenza, parotitis and viral hepatitis. Consequently, I. indigotica may be beneficial for the prevention and treatment of coronavirus disease 2019 (COVID-19).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>This paper reviewed the chemical constituents, pharmacological effects and clinical applications of I. indigotica which may guide further research and application of this plant.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpp\/rgab014","type":"journal-article","created":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T20:14:14Z","timestamp":1611087254000},"page":"1137-1150","source":"Crossref","is-referenced-by-count":66,"title":["<i>Isatis indigotica<\/i>: a review of phytochemistry, pharmacological activities and clinical applications"],"prefix":"10.1093","volume":"73","author":[{"given":"Qiong","family":"Chen","sequence":"first","affiliation":[{"name":"Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine , Shanghai ,","place":["China"]},{"name":"School of Pharmacy, Chengdu University of Traditional Chinese Medicine , Chengdu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Yue","family":"Lan","sequence":"additional","affiliation":[{"name":"Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Peng","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Chengdu University of Traditional Chinese Medicine , Chengdu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid","family":"Rahman","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Biomolecular Sciences, Faculty of Science, Liverpool John Moores University , Liverpool, England ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Chun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Chengdu Brilliant Pharmaceutical Co. Ltd. \u00a0 , Chengdu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Luan","sequence":"additional","affiliation":[{"name":"Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6191-0046","authenticated-orcid":false,"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine , Shanghai ,","place":["China"]},{"name":"School of Pharmacy, Chengdu University of Traditional Chinese Medicine , Chengdu 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