{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:26:06Z","timestamp":1787009166987,"version":"build-2736575974"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Cyclophosphamide (CPA) is highly effective in treating several human tumours and autoimmune disorders; but, it triggers deleterious side effects. Avocado, Persea americana (Mill.), is a widely consumed fruit with pronounced nutritional and medicinal value. Though many studies examined the protective mechanisms of natural products against CPA toxicity, almost none investigated the modulation of CPA metabolism as a potential underlying mechanism for protection. Here, we investigated the modulating effect of avocado extract (AE) on certain CPA metabolizing enzymes and its correlation with the extent of CPA-induced pulmonary toxicity and urotoxicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Rats received oral AE (0.9 g\/kg body weight\/day) 7 days before a single CPA injection (150 mg\/kg body weight) and continued AE intake for 2, 7 or 28 days to study three phases of CPA-induced urotoxicity and pulmonary toxicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key findings<\/jats:title>\n                    <jats:p>CPA acutely elevated then reduced hepatic microsomal cytochrome P450 2B6 (CYP2B6) content and significantly suppressed bladder and lung glutathione-S-transferase activity. Furthermore, CPA elevated lung myeloperoxidase activity, DNA content and hydroxyproline level and bladder blood content. AE ameliorated CPA-induced derangements through suppression of CYP2B6 and myeloperoxidase and augmentation of glutathione-S-transferase activity in CPA-treated rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>AE modulation of CPA metabolizing enzymes and potential anti-inflammatory effect may mitigate CPA-induced toxicity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jpp\/rgab084","type":"journal-article","created":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T07:23:05Z","timestamp":1620890585000},"page":"367-376","source":"Crossref","is-referenced-by-count":5,"title":["Amelioration of cyclophosphamide toxicity via modulation of metabolizing enzymes by avocado (\n                    <i>Persea<\/i>\n                    americana) extract"],"prefix":"10.1093","volume":"74","author":[{"given":"Tarek Mohamed Kamal","family":"Motawi","sequence":"first","affiliation":[{"name":"Biochemistry Department, Faculty of Pharmacy, Cairo University , Cairo ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mira Magdy","family":"William","sequence":"additional","affiliation":[{"name":"Biochemistry Department, Faculty of Pharmacy, October 6 University , Giza ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9794-4099","authenticated-orcid":false,"given":"Mohammed Mostafa","family":"Nooh","sequence":"additional","affiliation":[{"name":"Biochemistry Department, Faculty of Pharmacy, Cairo University , Cairo ,","place":["Egypt"]},{"name":"Biochemistry Department, Faculty of Pharmacy, October 6 University , Giza ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan Muhammad","family":"Abd-Elgawad","sequence":"additional","affiliation":[{"name":"Biochemistry Department, Faculty of Pharmacy, Cairo University , Cairo ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,3,1]]},"reference":[{"key":"2024103012162528900_CIT0001","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1517\/14740338.6.2.183","article-title":"The safety profile of cyclophosphamide in multiple sclerosis therapy","volume":"6","author":"Perini","year":"2007","journal-title":"Expert Opin Drug Saf"},{"key":"2024103012162528900_CIT0002","doi-asserted-by":"crossref","first-page":"41","DOI":"10.2165\/00003088-200140010-00004","article-title":"Clinical pharmacokinetics and pharmacodynamics of ifosfamide and its metabolites","volume":"40","author":"Kerbusch","year":"2001","journal-title":"Clin Pharmacokinet"},{"key":"2024103012162528900_CIT0003","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/toxsci\/57.1.6","article-title":"The molecular effects of acrolein","volume":"57","author":"Kehrer","year":"2000","journal-title":"Toxicol Sci"},{"key":"2024103012162528900_CIT0004","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1016\/j.juro.2009.01.015","article-title":"Sesquiterpene lactone parthenolide ameliorates bladder inflammation and bladder overactivity in cyclophosphamide induced rat cystitis model by inhibiting nuclear factor-kappaB phosphorylation","volume":"181","author":"Kiuchi","year":"2009","journal-title":"J Urol"},{"key":"2024103012162528900_CIT0005","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0940-2993(98)80085-7","article-title":"Cyclophosphamide-induced generation of reactive oxygen species. Comparison with morphological changes in type II alveolar epithelial cells and lung capillaries","volume":"50","author":"Sulkowska","year":"1998","journal-title":"Exp Toxicol Pathol"},{"key":"2024103012162528900_CIT0006","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0300-483X(92)90007-2","article-title":"Murine strain differences in metabolism and bladder toxicity of cyclophosphamide","volume":"75","author":"Fraiser","year":"1992","journal-title":"Toxicology"},{"key":"2024103012162528900_CIT0007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0041-008X(92)90089-B","article-title":"Pharmacokinetics, metabolic activation, and lung toxicity of cyclophosphamide in C57\/B16 and ICR mice","volume":"114","author":"Kanekal","year":"1992","journal-title":"Toxicol Appl Pharmacol"},{"key":"2024103012162528900_CIT0008","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0021-9673(92)87092-M","article-title":"Determination of the triglyceride composition of avocado oil by high-performance liquid chromatography using a light-scattering detector","volume":"607","author":"Hierro","year":"1992","journal-title":"J Chromatogr"},{"key":"2024103012162528900_CIT0009","first-page":"537","article-title":"Effects of a vegetarian diet vs. a vegetarian diet enriched with avocado in hypercholesterolemic patients","volume":"28","author":"Carranza-Madrigal","year":"1997","journal-title":"Arch Med Res"},{"key":"2024103012162528900_CIT0010","article-title":"The odyssey of bioactive compounds in Avocado (Persea americana) and their health benefits","volume":"8","author":"Bhuyan","year":"2019","journal-title":"Antioxidants (Basel)"},{"key":"2024103012162528900_CIT0011","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1021\/jf0207934","article-title":"Effect of different extraction methods on fatty acids, volatile compounds, and physical and chemical properties of avocado (Persea americana Mill.) oil","volume":"51","author":"Moreno","year":"2003","journal-title":"J Agric Food Chem"},{"key":"2024103012162528900_CIT0012","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0189-7241(15)30057-6","article-title":"Phytochemical, toxicological, biochemical and haematological studies on Avocado (Persea americana) in experimental animals","volume":"31","author":"Gouegni","year":"2013","journal-title":"Niger Food J"},{"key":"2024103012162528900_CIT0013","doi-asserted-by":"crossref","first-page":"210","DOI":"10.4314\/ajtcam.v8i3.65277","article-title":"Remnant B-cell-stimulative and anti-oxidative effects of Persea americana fruit extract studied in rats introduced into streptozotocin - induced hyperglycaemic state","volume":"8","author":"Rao","year":"2011","journal-title":"Afr J Tradit Complement Altern Med"},{"key":"2024103012162528900_CIT0014","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jchromb.2013.10.013","article-title":"Activity-guided identification of acetogenins as novel lipophilic antioxidants present in avocado pulp (Persea americana)","volume":"942-943","author":"Rodr\u00edguez-S\u00e1nchez","year":"2013","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"2024103012162528900_CIT0015","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.5897\/AJPP11.239","article-title":"Hypolipidemic and antioxidant activities of avocado fruit pulp on high cholesterol fed diet in rats","volume":"5","author":"Al-Dosari","year":"2011","journal-title":"Afr J Pharm Pharmacol"},{"key":"2024103012162528900_CIT0016","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1039\/C4FO00610K","article-title":"Isolation and chemical identification of lipid derivatives from avocado (Persea americana) pulp with antiplatelet and antithrombotic activities","volume":"6","author":"Rodriguez-Sanchez","year":"2015","journal-title":"Food Funct"},{"key":"2024103012162528900_CIT0017","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.urology.2005.10.003","article-title":"Epinephrine promotes hemostasis in rats with cyclophosphamide-induced hemorrhagic cystitis","volume":"67","author":"Chow","year":"2006","journal-title":"Urology"},{"key":"2024103012162528900_CIT0018","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1080\/00498250500057369","article-title":"Cyclophosphamide induces mRNA, protein and enzyme activity of cytochrome P450 in rat","volume":"35","author":"Xie","year":"2005","journal-title":"Xenobiotica"},{"key":"2024103012162528900_CIT0019","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","article-title":"Glutathione S-transferases. The first enzymatic step in mercapturic acid formation","volume":"249","author":"Habig","year":"1974","journal-title":"J Biol Chem"},{"key":"2024103012162528900_CIT0020","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/0016-5085(84)90202-6","article-title":"Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Assessment of inflammation in rat and hamster models","volume":"87","author":"Krawisz","year":"1984","journal-title":"Gastroenterology"},{"key":"2024103012162528900_CIT0021","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0003-2697(88)90156-X","article-title":"Diphenylamine-colorimetric method for DNA assay: a shortened procedure by incubating samples at 50 degrees C","volume":"173","author":"Gendimenico","year":"1988","journal-title":"Anal Biochem"},{"key":"2024103012162528900_CIT0022","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0009-9120(96)00003-6","article-title":"A simplified method for the analysis of hydroxyproline in biological tissues","volume":"29","author":"Reddy","year":"1996","journal-title":"Clin Biochem"},{"key":"2024103012162528900_CIT0023","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J Biol Chem"},{"key":"2024103012162528900_CIT0024","doi-asserted-by":"crossref","first-page":"36636","DOI":"10.1074\/jbc.M113.507756","article-title":"Potent reversible inhibition of myeloperoxidase by aromatic hydroxamates","volume":"288","author":"Forbes","year":"2013","journal-title":"J Biol Chem"},{"key":"2024103012162528900_CIT0025","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0031-9422(00)00055-8","article-title":"Antifungal compounds from idioblast cells isolated from avocado fruits","volume":"54","author":"Domergue","year":"2000","journal-title":"Phytochemistry"},{"key":"2024103012162528900_CIT0026","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1021\/jf990977r","article-title":"Novel nitric oxide and superoxide generation inhibitors, persenone A and B, from avocado fruit","volume":"48","author":"Kim","year":"2000","journal-title":"J Agric Food Chem"},{"key":"2024103012162528900_CIT0027","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1021\/jf0015120","article-title":"Liver injury suppressing compounds from avocado (Persea americana)","volume":"49","author":"Kawagishi","year":"2001","journal-title":"J Agric Food Chem"},{"key":"2024103012162528900_CIT0028","doi-asserted-by":"crossref","first-page":"194","DOI":"10.2165\/00003088-199120030-00002","article-title":"Clinical pharmacokinetics of cyclophosphamide","volume":"20","author":"Moore","year":"1991","journal-title":"Clin Pharmacokinet"},{"key":"2024103012162528900_CIT0029","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1124\/mol.65.5.1278","article-title":"Activation of the anticancer prodrugs cyclophosphamide and ifosfamide: identification of cytochrome P450 2B enzymes and site-specific mutants with improved enzyme kinetics","volume":"65","author":"Chen","year":"2004","journal-title":"Mol Pharmacol"},{"key":"2024103012162528900_CIT0030","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/00008571-199906000-00004","article-title":"Human CYP2B6: expression, inducibility and catalytic activities","volume":"9","author":"Gervot","year":"1999","journal-title":"Pharmacogenetics"},{"key":"2024103012162528900_CIT0031","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1124\/dmd.30.7.814","article-title":"The effect of cyclophosphamide with and without dexamethasone on cytochrome P450 3A4 and 2B6 in human hepatocytes","volume":"30","author":"Lindley","year":"2002","journal-title":"Drug Metab Dispos"},{"key":"2024103012162528900_CIT0032","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1023\/A:1023234429596","article-title":"Induction of cytochrome P450 2B6 and 3A4 expression by phenobarbital and cyclophosphamide in cultured human liver slices","volume":"20","author":"Martin","year":"2003","journal-title":"Pharm Res"},{"key":"2024103012162528900_CIT0033","first-page":"258","article-title":"Suppression of rat hepatic microsomal cytochromes P450 by cyclophosphamide is correlated with plasma thyroid hormone levels and displays differential strain sensitivity","volume":"276","author":"Kraner","year":"1996","journal-title":"J Pharmacol Exp Ther"},{"key":"2024103012162528900_CIT0034","first-page":"110","article-title":"Metabolism and distribution of [2,3-14C]acrolein in Sprague-Dawley rats. II. Identification of urinary and fecal metabolites","volume":"43","author":"Parent","year":"1998","journal-title":"Toxicol Sci"},{"key":"2024103012162528900_CIT0035","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1089\/ars.2007.1916","article-title":"Antioxidants as potential therapeutics for lung fibrosis","volume":"10","author":"Day","year":"2008","journal-title":"Antioxid Redox Signal"},{"key":"2024103012162528900_CIT0036","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s11033-011-0763-9","article-title":"The cyclophosphamide metabolite, acrolein, induces cytoskeletal changes and oxidative stress in Sertoli cells","volume":"39","author":"Liu","year":"2012","journal-title":"Mol Biol Rep"},{"key":"2024103012162528900_CIT0037","doi-asserted-by":"crossref","first-page":"237","DOI":"10.4314\/ajtcam.v11i2.2","article-title":"Hepatoprotective properties of aqueous leaf extract of Persea Americana, Mill (Lauraceae) \u2018avocado\u2019 against CCL4-induced damage in rats","volume":"11","author":"Brai","year":"2014","journal-title":"Afr J Tradit Complement Altern Med"},{"key":"2024103012162528900_CIT0038","doi-asserted-by":"crossref","first-page":"3204","DOI":"10.1021\/jf900541r","article-title":"Fatty acids, sterols, and antioxidant activity in minimally processed avocados during refrigerated storage","volume":"57","author":"Plaza","year":"2009","journal-title":"J Agric Food Chem"},{"key":"2024103012162528900_CIT0039","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.nutres.2014.07.010","article-title":"Carotenoids, inflammation, and oxidative stress\u2013implications of cellular signaling pathways and relation to chronic disease prevention","volume":"34","author":"Kaulmann","year":"2014","journal-title":"Nutr Res"},{"key":"2024103012162528900_CIT0040","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1097\/CEJ.0b013e32835b69ff","article-title":"Effect of carotenoid lutein on N-nitrosodiethylamine-induced hepatocellular carcinoma and its mechanism of action","volume":"22","author":"Sindhu","year":"2013","journal-title":"Eur J Cancer Prev"},{"key":"2024103012162528900_CIT0041","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/sj.bmt.1704763","article-title":"Cardiac toxicity of high-dose chemotherapy","volume":"35","author":"Morandi","year":"2005","journal-title":"Bone Marrow Transplant"},{"key":"2024103012162528900_CIT0042","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.fct.2013.11.023","article-title":"Mechanism for the protective effect of diallyl disulfide against cyclophosphamide acute urotoxicity in rats","volume":"64","author":"Kim","year":"2014","journal-title":"Food Chem Toxicol"},{"key":"2024103012162528900_CIT0043","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s002800050594","article-title":"Urinary excretion of ifosfamide, 4-hydroxyifosfamide, 3- and 2-dechloroethylifosfamide, mesna, and dimesna in patients on fractionated intravenous ifosfamide and concomitant mesna therapy","volume":"39","author":"Kurowski","year":"1997","journal-title":"Cancer Chemother Pharmacol"},{"key":"2024103012162528900_CIT0044","doi-asserted-by":"crossref","first-page":"180","DOI":"10.4062\/biomolther.2014.126","article-title":"Diallyl disulfide prevents cyclophosphamide-induced hemorrhagic cystitis in rats through the inhibition of oxidative damage, MAPKs, and NF-\u03baB pathways","volume":"23","author":"Kim","year":"2015","journal-title":"Biomol Ther (Seoul)"},{"key":"2024103012162528900_CIT0045","doi-asserted-by":"crossref","first-page":"R574","DOI":"10.1152\/ajpregu.00465.2002","article-title":"COX-2 and prostanoid expression in micturition pathways after cyclophosphamide-induced cystitis in the rat","volume":"284","author":"Hu","year":"2003","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2024103012162528900_CIT0046","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1271\/bbb.64.2504","article-title":"An avocado constituent, persenone A, suppresses expression of inducible forms of nitric oxide synthase and cyclooxygenase in macrophages, and hydrogen peroxide generation in mouse skin","volume":"64","author":"Kim","year":"2000","journal-title":"Biosci Biotechnol Biochem"},{"key":"2024103012162528900_CIT0047","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0378-4274(96)03845-3","article-title":"Pirfenidone diminishes cyclophosphamide-induced lung fibrosis in mice","volume":"90","author":"Kehrer","year":"1997","journal-title":"Toxicol Lett"},{"key":"2024103012162528900_CIT0048","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0163-7258(90)90049-8","article-title":"Metabolism and pulmonary toxicity of cyclophosphamide","volume":"47","author":"Patel","year":"1990","journal-title":"Pharmacol Ther"},{"key":"2024103012162528900_CIT0049","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.fct.2013.03.046","article-title":"Ellagic acid attenuates bleomycin and cyclophosphamide-induced pulmonary toxicity in Wistar rats","volume":"58","author":"","year":"2013","journal-title":"Food Chem Toxicol"},{"key":"2024103012162528900_CIT0050","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/S0006-2952(98)00221-4","article-title":"Biochemical and connective tissue changes in cyclophosphamide-induced lung fibrosis in rats","volume":"56","author":"Venkatesan","year":"1998","journal-title":"Biochem Pharmacol"},{"key":"2024103012162528900_CIT0051","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.bbrc.2011.05.027","article-title":"Aliphatic acetogenin constituents of avocado fruits inhibit human oral cancer cell proliferation by targeting the EGFR\/RAS\/RAF\/MEK\/ERK1\/2 pathway","volume":"409","author":"D'Ambrosio","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"key":"2024103012162528900_CIT0052","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1167\/iovs.05-1429","article-title":"Inhibitory effects of lutein on endotoxin-induced uveitis in Lewis rats","volume":"47","author":"Jin","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2024103012162528900_CIT0053","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0300-483X(97)00149-2","article-title":"Mixed effects of 2,6-dithiopurine against cyclophosphamide mediated bladder and lung toxicity in mice","volume":"125","author":"Datta","year":"1998","journal-title":"Toxicology"},{"key":"2024103012162528900_CIT0054","first-page":"188","article-title":"Natural remedies for scleroderma","volume":"11","author":"Gaby","year":"2006","journal-title":"Altern Med Rev"},{"key":"2024103012162528900_CIT0055","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/BF02638904","article-title":"Chemical characterization of lysyl oxidase inhibitor from avocado seed oil","volume":"72","author":"Rosenblat","year":"1995","journal-title":"J Am Oil Chem Soc"}],"container-title":["Journal of Pharmacy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/74\/3\/367\/60218516\/rgab084.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/74\/3\/367\/60218516\/rgab084.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T12:57:13Z","timestamp":1730293033000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpp\/article\/74\/3\/367\/6309951"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,1]]},"references-count":55,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,3,1]]},"published-print":{"date-parts":[[2022,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jpp\/rgab084","relation":{},"ISSN":["0022-3573","2042-7158"],"issn-type":[{"value":"0022-3573","type":"print"},{"value":"2042-7158","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,3,1]]},"published":{"date-parts":[[2022,3,1]]}}}