{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T12:08:32Z","timestamp":1782302912184,"version":"3.54.5"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>We investigated, the effects of aprepitant (APRE) on the lung tissues of rats with an experimental polymicrobial sepsis model (CLP: cecal ligation and puncture) biochemically, molecularly and histopathologically.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A total of 40 rats were divided into 5 groups with 8 animals in each group. Group 1 (SHAM), control group; Group 2 (CLP), cecal ligation and puncture; Group 3 (CLP + APRE10), rats were administered CLP + 10 mg\/kg aprepitant; Group 4 (CLP + APRE20), rats were administered CLP + 20 mg\/kg aprepitant; and Group 5 (CLP + APRE40), rats were administered CLP + 40 mg\/kg aprepitant. A polymicrobial sepsis model was induced with CLP. After 16 h, lung tissues were taken for examination. Tumour necrosis factor \u03b1 (TNF-\u03b1) and nuclear factor-kappa b (NFK-b) messenger ribonucleic acid (mRNA) expressions were analysed by real-time PCR (RT-PCR), biochemically antioxidant parameters such as superoxide dismutase (SOD) and glutathione (GSH) and oxidant parameters such as malondialdehyde (MDA) and lung damage histopathologically.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings and conclusions<\/jats:title>\n                  <jats:p>The GSH level and SOD activity increased while the MDA level and the expressions of TNF-\u03b1 and NFK-b were reduced in the groups treated with APRE, especially in the CLP + APRE40 group. The histopathology results supported the molecular and biochemical results.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpp\/rgab088","type":"journal-article","created":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T19:18:40Z","timestamp":1621538320000},"page":"1302-1309","source":"Crossref","is-referenced-by-count":17,"title":["Aprepitant: an antiemetic drug, contributes to the prevention of acute lung injury with its anti-inflammatory and antioxidant properties"],"prefix":"10.1093","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3468-1567","authenticated-orcid":false,"given":"Duygu","family":"Kose","sequence":"first","affiliation":[{"name":"Clinical Research, Development and Design Application, and Research Center, Ataturk University , Erzurum ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harun","family":"Un","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Department of Biochemistry, Agri \u0130brahim \u00c7e\u00e7en University , A\u011fr\u0131 ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rustem Anil","family":"Ugan","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Department of Pharmacology, Atat\u00fcrk University , Erzurum ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8109-8390","authenticated-orcid":false,"given":"Zekai","family":"Halici","sequence":"additional","affiliation":[{"name":"Clinical Research, Development and Design Application, and Research Center, Ataturk University , Erzurum ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif","family":"Cadirci","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pharmacology, Atat\u00fcrk University , Erzurum ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tugba Bal","family":"Tastan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Histology and Embryology Department, Binali Y\u0131ld\u0131r\u0131m University , Erzincan ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aysenur","family":"Kahramanlar","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Department of Biochemistry, Ataturk University , Erzurum ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,10,1]]},"reference":[{"key":"2024110604185234500_CIT0001","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1056\/NEJMoa022139","article-title":"The epidemiology of sepsis in the United States from 1979 through 2000","volume":"348","author":"Martin","year":"2003","journal-title":"N Engl J Med"},{"key":"2024110604185234500_CIT0002","first-page":"1","article-title":"Protective effects of idebenone against sepsis induced acute lung damage","volume":"15","author":"Akpinar","year":"2021","journal-title":"J Invest Surg"},{"key":"2024110604185234500_CIT0003","first-page":"807","article-title":"Lipoxin A4 alleviates lung injury in sepsis rats through p38\/MAPK signaling pathway","volume":"34","author":"Hu","year":"2020","journal-title":"J Biol Regul Homeost Agents"},{"key":"2024110604185234500_CIT0004","first-page":"664","article-title":"Paeoniflorin improves acute lung injury in sepsis by activating Nrf2\/Keap1 signaling pathway","volume":"51","author":"Ling","year":"2020","journal-title":"Sichuan Da Xue Xue Bao Yi Xue Ban"},{"key":"2024110604185234500_CIT0005","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1056\/NEJMra1208623","article-title":"Severe sepsis and septic shock","volume":"369","author":"Angus","year":"2013","journal-title":"N Engl J Med"},{"key":"2024110604185234500_CIT0006","first-page":"665","article-title":"Acute respiratory distress syndrome. 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