{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:26:06Z","timestamp":1787009166650,"version":"build-2736575974"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T00:00:00Z","timestamp":1625788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study was to determine whether alamandine (Ala) could reduce ischaemia and reperfusion (I\/R) injury of kidney in rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Renal I\/R was induced by an occlusion of bilateral renal arteries for 70 min and a 24-h reperfusion in vivo, and rat kidney proximal tubular epithelial cells NRK52E were exposed to 24 h of hypoxia and followed by 3-h reoxygenation (H\/R) in vitro.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The elevated serum creatinine (Cr), blood cystatin C (CysC) and blood urea nitrogen (BUN) levels in I\/R rats were inhibited by Ala treatment. Tumour necrosis factor alpha (TNF)-\u03b1, IL-1\u03b2, IL-6, cleaved caspase-3, cleaved caspase-8 and Bax were increased, and Bcl2 was reduced in the kidney of I\/R rats, which were reversed by Ala administration. Ala reversed the increase of TNF-\u03b1, IL-1\u03b2, IL-6, cleaved caspase-3, cleaved caspase-8 and Bax and the decrease of Bcl2 in the H\/R NRK52E cells. Ala could also inhibit the increase of oxidative stress levels in the kidney of I\/R rats. NADPH oxidase 1 (Nox1) overexpression reversed the improving effects of Ala on renal function, inflammation and apoptosis of I\/R rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These results indicated that Ala could improve renal function, attenuate inflammation and apoptosis in the kidney of I\/R rats via inhibiting oxidative stress.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jpp\/rgab091","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T07:57:43Z","timestamp":1623225463000},"page":"1491-1502","source":"Crossref","is-referenced-by-count":21,"title":["Alamandine protects against renal ischaemia\u2013reperfusion injury in rats via inhibiting oxidative stress"],"prefix":"10.1093","volume":"73","author":[{"given":"Jue","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Nephrology, People\u2019s Hospital of Liyang , Changzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Guo","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Urology, Lianshui People\u2019s Hospital Affiliated to Kangda College of Nanjing Medical University , Huaian ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Tao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Zaozhuang Mining Group Central Hospital , Zaozhuang ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Xiang","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Urology, People\u2019s Hospital of Liyang , Changzhou 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