{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T18:31:36Z","timestamp":1779301896856,"version":"3.51.4"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100013704","name":"Council for Science and Technology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100013704","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Program for Technological Research and Innovation Projects UNAM-DGAPA-PAPIIT","award":["IN201820"],"award-info":[{"award-number":["IN201820"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To analyse the antinociceptive interaction between quercetin (QUER) and diclofenac (DIC) in experimental arthritic gout-pain.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The antinociceptive effect of DIC and QUER alone and in combination were evaluated using an arthritic gout-pain model. Pain was induced through intra-articular administration of uric acid in the rats and the treatments were administered 2 h later. Additionally, the cyclooxygenase (COX) activity was determined in rats treated with DIC, QUER and their combination.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>DIC induced a maximal effect of 69.7 \u00b1 2.7% with 3.1 mg\/kg; whereas QUER only produced 17.6 \u00b1 2.6% with the maximal dose (316 mg\/kg). Ten of twelve DIC + QUER combinations showed a lesser antinociceptive effect than DIC alone did (P &amp;lt; 0.05). Moreover, DIC reduced total-COX (70.4 \u00b1 1.3 versus 52.4 \u00b1 1.8 and 77.4 \u00b1 9.0 versus 56.1 \u00b1 1.3, P &amp;lt; 0.05) and COX-2 (60.1 \u00b1 1.0 versus 42.4 \u00b1 1.8 and 58.1 \u00b1 2.4 versus 48.7 \u00b1 1.3, P &amp;lt; 0.05) activity after 1 and 3 h, respectively. Nevertheless, only the COX-2 activity induced by DIC was prevented in the presence of QUER (63.2 \u00b1 3.0 versus 60.1 \u00b1 1.0 and 56.6 \u00b1 1.3 versus 58.1 \u00b1 2.4 at 1 and 3 h, respectively).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>All these data demonstrated that the simultaneous administration of QUER + DIC produces an unfavorable interaction on the antinociceptive effect of DIC. Therefore, this combination might not be recommendable to relieve arthritic gout-pain.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpp\/rgab093","type":"journal-article","created":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T19:53:10Z","timestamp":1623095590000},"page":"1310-1318","source":"Crossref","is-referenced-by-count":8,"title":["Quercetin decreases the antinociceptive effect of diclofenac in an arthritic gout-pain model in rats"],"prefix":"10.1093","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6580-2886","authenticated-orcid":false,"given":"Rosa","family":"Ventura-Mart\u00ednez","sequence":"first","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM) , Ciudad de M\u00e9xico ,","place":["M\u00e9xico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1467-9486","authenticated-orcid":false,"given":"Myrna","family":"D\u00e9ciga-Campos","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional (IPN) , Ciudad de M\u00e9xico ,","place":["M\u00e9xico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Araceli","family":"Bustamante-Marquina","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional (IPN) , Ciudad de M\u00e9xico ,","place":["M\u00e9xico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guadalupe Esther","family":"\u00c1ngeles-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM) , Ciudad de M\u00e9xico ,","place":["M\u00e9xico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Aviles-Herrera","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM) , Ciudad de M\u00e9xico ,","place":["M\u00e9xico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Eva","family":"Gonz\u00e1lez-Trujano","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurofarmacolog\u00eda de Productos Naturales, Direcci\u00f3n de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatr\u00eda \u201cRam\u00f3n de la Fuente Mu\u00f1iz\u201d , Ciudad de M\u00e9xico ,","place":["M\u00e9xico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Navarrete-V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Facultad de Farmacia, Universidad Aut\u00f3noma del Estado de Morelos (UAEM) , Cuernavaca, Morelos ,","place":["M\u00e9xico"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,10,1]]},"reference":[{"key":"2024110604191577400_CIT0001","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1097\/j.pain.0000000000001939","article-title":"The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises","volume":"161","author":"Raja","year":"2020","journal-title":"Pain"},{"key":"2024110604191577400_CIT0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/pr.55.1.1","article-title":"Topical and peripherally acting analgesics","volume":"55","author":"Sawynok","year":"2003","journal-title":"Pharmacol Rev"},{"key":"2024110604191577400_CIT0003","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1073\/pnas.0409225102","article-title":"A cascade of cytokines mediates mechanical inflammatory hypernociception in mice","volume":"102","author":"Cunha","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024110604191577400_CIT0004","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3899\/jrheum.100951","article-title":"Epidemiology of the rheumatic diseases in Mexico. 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