{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T14:16:34Z","timestamp":1787580994453,"version":"build-2736575974"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Autism spectrum disorder (ASD) is categorized as a neurodevelopmental disorder, presenting with a variety of aetiological and phenotypical features. Inhibiting the enzyme phosphodiesterase-3 (PDE3) with cilostazol is known to produce beneficial effects in several brain disorders. The pharmacological outcome of cilostazol administration was investigated in prenatal valproic acid (VPA)-induced ASD deficits in albino Wistar rats.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Cilostazol was administered in two doses (30\/60 mg\/kg) to male rats born of females administered with VPA on gestational day 12. Behavioural assays on locomotion (open field), social interaction, repetitive behaviour (y-maze) and anxiety (elevated plus maze) were performed in all groups. Further, biochemical assessments of markers associated with neuronal function (BDNF, pCREB), inflammation (TNF-\u03b1, IL-6, IL-10) and oxidative stress were carried out in frontal cortex, hippocampus, striatum and cerebellum.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>The cilostazol regimen, attenuated prenatal VPA exposure associated hyperlocomotion, social interaction deficits, repetitive behavior, and anxiety. Further, biochemical markers such as BDNF, pCREB, IL-10 and GSH were found to be significantly increased contrary to markers such as TNF-\u03b1, IL-6 and TBARS in the assessed brain regions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Cilostazol rectified core behavioural traits while producing significant changes to biochemistry in the brain, suggesting benefits of cilostazol administration in experimental models of ASD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpp\/rgab115","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T11:13:57Z","timestamp":1627643637000},"page":"1460-1469","source":"Crossref","is-referenced-by-count":22,"title":["Cilostazol attenuated prenatal valproic acid-induced behavioural and biochemical deficits in a rat model of autism spectrum disorder"],"prefix":"10.1093","volume":"73","author":[{"given":"Kanishk","family":"Luhach","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Amity Institute of Pharmacy, Amity University Uttar Pradesh , Noida, Uttar Pradesh ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giriraj T","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Gokaraju Rangaraju College of Pharmacy , Hyderabad ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay P","family":"Singh","sequence":"additional","affiliation":[{"name":"CSIR-Institute of Genomics & Integrative Biology, Academy of Scientific and Innovative Research , New Delhi 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