{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T07:34:06Z","timestamp":1782977646637,"version":"3.54.5"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Our aim is to explain the relationship between Ang II and Scl in osteoporotic (OP) rats and the contribution of Scl in the antiosteoporotic effect mechanism of angiotensin receptor blockers (ARB).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This study consists of two sub-studies conducted on 4th and 12th weeks after ovariectomy. In study 1, treatment was started immediately after bilateral ovariectomy (OVX), while, in study 2, treatment was started 2 months after OVX. Two different doses of telmisartan (5 and 10 mg\/kg) were administered with the aid of gavage for 30 days in both sub-study groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Serum and tissue Scl, osteocalcin, osteopontin and tartrate-resistant acid phosphatase mRNA expressions were higher and bone mineral densities (BMD) and bone-specific alkaline phosphatase (BALP) mRNA expressions were found to be lower in the OVX groups compared with the sham group. In OVX groups where two different doses of telmisartan were administered, BMD and BALP mRNA expressions increased and serum and tissue Scl decreased.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>There may be a close relationship between angiotensin II and sclerostin in the development of osteoporosis. In this study, telmisartan administration showed an antiosteoporotic effect and significantly decreased the level of sclerostin. These results strongly support this relationship.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpp\/rgab123","type":"journal-article","created":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T20:37:58Z","timestamp":1629232678000},"page":"1693-1702","source":"Crossref","is-referenced-by-count":2,"title":["The relationship of telmisartan with sclerostin in the osteoporosis model induced by ovariectomy in rats"],"prefix":"10.1093","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6279-9810","authenticated-orcid":false,"given":"Zerrin","family":"Kutlu","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy, Ataturk University , Erzurum ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9017-8344","authenticated-orcid":false,"given":"Arzu","family":"Bilen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Ataturk University , Erzurum ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9536-8101","authenticated-orcid":false,"given":"Muhammet","family":"Celik","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, School of Medicine, Ataturk University , Erzurum ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7742-1028","authenticated-orcid":false,"given":"Adem","family":"Maman","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, School of Medicine, Ataturk University , Erzurum ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mine","family":"Gulaboglu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy, Ataturk University , Erzurum ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1313-9469","authenticated-orcid":false,"given":"Ayhan","family":"Kul","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Medical Faculty of Ataturk University Erzurum , Erzurum ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynep","family":"Celik","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy, Ataturk University , Erzurum ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6854-6059","authenticated-orcid":false,"given":"Zekai","family":"Halici","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pharmacology, Ataturk University , Erzurum ,","place":["Turkey"]},{"name":"Clinical Research, Development and Design Application and Research Center, Ataturk University , Erzurum ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,12,1]]},"reference":[{"key":"2024103012144222100_CIT0001","doi-asserted-by":"crossref","first-page":"115121","DOI":"10.1016\/j.bone.2019.115121","article-title":"Denosumab or romosozumab therapy and risk of cardiovascular events in patients with primary osteoporosis: systematic review and meta-analysis","volume":"130","author":"Fang","year":"2020","journal-title":"Bone"},{"key":"2024103012144222100_CIT0002","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/s00223-013-9731-9","article-title":"The association between osteoporosis and hypertension: the role of a low dairy intake","volume":"93","author":"Varenna","year":"2013","journal-title":"Calcif Tissue Int"},{"key":"2024103012144222100_CIT0003","doi-asserted-by":"crossref","first-page":"100216","DOI":"10.1016\/j.bonr.2019.100216","article-title":"An insight into the paradigms of osteoporosis: from genetics to biomechanics","volume":"11","author":"Al Anouti","year":"2019","journal-title":"Bone Rep"},{"key":"2024103012144222100_CIT0004","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.17219\/acem\/68739","article-title":"Sclerostin: intracellular mechanisms of action and its role in the pathogenesis of skeletal and vascular disorders","volume":"26","author":"Pietrzyk","year":"2017","journal-title":"Adv Clin Exp Med"},{"key":"2024103012144222100_CIT0005","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.beem.2018.05.003","article-title":"Bone turnover: biology and assessment tools","volume":"32","author":"Szulc","year":"2018","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"2024103012144222100_CIT0006","doi-asserted-by":"crossref","first-page":"58","DOI":"10.4274\/tod.19483","article-title":"Yeni tan\u0131 alan postmenopozal osteoporozda kemik d\u00f6ng\u00fcs\u00fc belirte\u00e7leri k\u0131r\u0131k riski ile ili\u015fkili midir? 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