{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T08:45:57Z","timestamp":1777538757242,"version":"3.51.4"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["#310113\/2017-2"],"award-info":[{"award-number":["#310113\/2017-2"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005667","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e Inova\u00e7\u00e3o do Estado de Santa Catarina","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005667","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>This study investigated the involvement of heme oxygenase-1 (HO-1) in the antidepressant-like effects of ursolic acid (UA), a plant-derived compound with neuroprotective and antidepressant-like properties.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Mice received intracerebroventricular injections of zinc protoporphyrin IX (ZnPP) or cobalt protoporphyrin IX (CoPP) to inhibit or induce HO-1, respectively, together with effective (0.1 mg\/kg, p.o.) or sub-effective (0.01 mg\/kg, p.o.) doses of UA or fluoxetine (10 mg\/kg, p.o.). Immobility time was assessed using the tail suspension test (TST) and the ambulatory behaviour with the open field test. HO-1 immunocontent was evaluated in mice hippocampus and prefrontal cortex.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>ZnPP prevented the anti-immobility effects of UA and fluoxetine. Combined treatment with a sub-effective dose of CoPP and UA synergistically exerted antidepressant-like effects in the TST. Acute administration of UA or CoPP, but not fluoxetine, increased the HO-1 immunocontent in the hippocampus. None of the treatments altered the HO-1 immunocontent in the prefrontal cortex.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In conclusion, this work shows that increased hippocampal HO-1 content and activity mediate the antidepressant-like effect of UA in the TST.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpp\/rgab128","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T19:10:51Z","timestamp":1628881851000},"page":"13-21","source":"Crossref","is-referenced-by-count":6,"title":["Role of heme oxygenase-1 in the antidepressant-like effect of ursolic acid in the tail suspension test"],"prefix":"10.1093","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3376-5977","authenticated-orcid":false,"given":"Ana Belen","family":"Ramos-Hryb","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Center of Biological Sciences, Universidade Federal de Santa Catarina, Campus Universit\u00e1rio , Florian\u00f3polis ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis L","family":"Pazini","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Center of Biological Sciences, Universidade Federal de Santa Catarina, Campus Universit\u00e1rio , Florian\u00f3polis ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Paula","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Center of Biological Sciences, Universidade Federal de Santa Catarina, Campus Universit\u00e1rio , Florian\u00f3polis ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauricio P","family":"Cunha","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Center of Biological Sciences, Universidade Federal de Santa Catarina, Campus Universit\u00e1rio , Florian\u00f3polis ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuella P","family":"Kaster","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Center of Biological Sciences, Universidade Federal de Santa Catarina, Campus Universit\u00e1rio , Florian\u00f3polis ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana L\u00facia S","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Center of Biological Sciences, Universidade Federal de Santa Catarina, Campus Universit\u00e1rio , Florian\u00f3polis ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,1,1]]},"reference":[{"key":"2024103012162325500_CIT0001","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/S0531-5565(00)00148-0","article-title":"Heme oxygenase-1: role in brain aging and neurodegeneration","volume":"35","author":"Schipper","year":"2000","journal-title":"Exp Gerontol"},{"key":"2024103012162325500_CIT0002","doi-asserted-by":"crossref","first-page":"e50138","DOI":"10.1371\/journal.pone.0050138","article-title":"Desipramine protects neuronal cell death and induces heme oxygenase-1 expression in Mes23.5 dopaminergic neurons","volume":"7","author":"Lin","year":"2012","journal-title":"PLoS One"},{"key":"2024103012162325500_CIT0003","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.3892\/etm.2013.995","article-title":"Upregulation of heme oxygenase-1 expression may facilitate memory and learning in mice","volume":"5","author":"Chen","year":"2013","journal-title":"Exp Ther Med"},{"key":"2024103012162325500_CIT0004","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0021-9258(17)42488-4","article-title":"Characterization of two constitutive forms of rat liver microsomal heme oxygenase. 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