{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T18:52:48Z","timestamp":1789671168271,"version":"4.0.1"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173911"],"award-info":[{"award-number":["82173911"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973406"],"award-info":[{"award-number":["81973406"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012476","name":"Fundamental Research Funds for Central Universities of the Central South University","doi-asserted-by":"publisher","award":["2021zzts1057"],"award-info":[{"award-number":["2021zzts1057"]}],"id":[{"id":"10.13039\/501100012476","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hunan Provincial Natural Scientific Foundation","award":["2019JJ50849"],"award-info":[{"award-number":["2019JJ50849"]}]},{"name":"Hunan Provincial Natural Scientific Foundation","award":["2020JJ4823"],"award-info":[{"award-number":["2020JJ4823"]}]},{"name":"Scientific Research Project of Hunan Provincial Health and Family Planning Commission","award":["No. 202113050843"],"award-info":[{"award-number":["No. 202113050843"]}]},{"name":"Bethune Quest-Pharmaceutical Research Capacity Building Project","award":["B-19-H-20200622"],"award-info":[{"award-number":["B-19-H-20200622"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Disulfiram (DSF), an old drug for treating chronic alcohol addiction, has been reported to exhibit widely pharmacological actions. This study aimed to explore the protective effect of DSF on lipopolysaccharide (LPS)-induced acute kidney injury (AKI).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>C57BL\/6J mice were treated with 15 mg\/kg LPS (i.p.) with or without DSF pre-treatment (i.p.). The histopathological analysis was conducted by H&amp;E staining and TUNEL kit assay. An automatic biochemical analyser was used to determine the serum creatinine and blood urea nitrogen (BUN). Expressions of 8-OHdG, NLRP3 and IL-1\u03b2 in the kidney tissues were observed by IHC staining. The protein expressions of \u03b2-actin, Bax, Bcl-2, NLRP3, caspase-1 (p20), pro-IL-1\u03b2 and IL-1\u03b2 were analysed by western blot.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>DSF attenuated the histopathologic deterioration of the kidney and inhibited the elevation of creatinine and BUN levels in mice. DSF inhibited LPS-induced cell apoptosis. Moreover, DSF treatment reversed the LPS-induced excessive oxidative stress. The NLRP3 inflammasome activation induced by the LPS, as indicated by up-regulation of NLRP3 expression, cleaved caspase-1 (p20) and IL-1\u03b2, was also suppressed by DSF.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The study here shows that DSF protects against the AKI induced by LPS at least partially via inhibiting oxidative stress and NLRP3 inflammasome activation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpp\/rgab171","type":"journal-article","created":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T12:16:16Z","timestamp":1637669776000},"page":"259-267","source":"Crossref","is-referenced-by-count":14,"title":["Disulfiram attenuates lipopolysaccharide-induced acute kidney injury by suppressing oxidative stress and NLRP3 inflammasome activation in mice"],"prefix":"10.1093","volume":"74","author":[{"given":"Jie","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Pharmacy, The Second Xiangya Hospital, Central South University , Changsha, Hunan ,","place":["China"]},{"name":"Institute of Clinical Pharmacy, Central South University , Changsha, Hunan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Second Xiangya Hospital, Central South University , Changsha, Hunan ,","place":["China"]},{"name":"Institute of Clinical Pharmacy, Central South University , Changsha, Hunan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Second Xiangya Hospital, Central South University , Changsha, Hunan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijun","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Second Xiangya Hospital, Central South University , Changsha, Hunan ,","place":["China"]},{"name":"Institute of Clinical Pharmacy, Central South University , Changsha, Hunan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanying","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Second Xiangya Hospital, Central South University , Changsha, Hunan ,","place":["China"]},{"name":"Institute of Clinical Pharmacy, Central South University , Changsha, Hunan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Second Xiangya Hospital, Central South University , Changsha, Hunan ,","place":["China"]},{"name":"Institute of Clinical Pharmacy, Central South University , Changsha, Hunan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bikui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Second Xiangya Hospital, Central South University , Changsha, Hunan ,","place":["China"]},{"name":"Institute of Clinical Pharmacy, Central South University , Changsha, Hunan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2939-7710","authenticated-orcid":false,"given":"Wenqun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Second Xiangya Hospital, Central South University , Changsha, Hunan ,","place":["China"]},{"name":"Institute of Clinical Pharmacy, Central South University , Changsha, Hunan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,2,1]]},"reference":[{"key":"2024103012162686500_CIT0001","doi-asserted-by":"crossref","first-page":"ITC66","DOI":"10.7326\/AITC201711070","article-title":"Acute kidney injury","volume":"167","author":"Levey","year":"2017","journal-title":"Ann Intern Med"},{"key":"2024103012162686500_CIT0002","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1016\/S0140-6736(15)60126-X","article-title":"International Society of Nephrology\u2019s 0by25 initiative for acute kidney injury (zero preventable deaths by 2025): a human rights case for nephrology","volume":"385","author":"Mehta","year":"2015","journal-title":"Lancet"},{"key":"2024103012162686500_CIT0003","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.kint.2019.05.026","article-title":"Acute kidney injury from sepsis: current concepts, epidemiology, pathophysiology, prevention and treatment","volume":"96","author":"Peerapornratana","year":"2019","journal-title":"Kidney Int"},{"key":"2024103012162686500_CIT0004","doi-asserted-by":"crossref","first-page":"k4891","DOI":"10.1136\/bmj.k4891","article-title":"Sepsis associated acute kidney injury","volume":"364","author":"Poston","year":"2019","journal-title":"BMJ"},{"key":"2024103012162686500_CIT0005","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(18)30696-2","article-title":"Sepsis and septic shock","volume":"392","author":"Cecconi","year":"2018","journal-title":"Lancet"},{"key":"2024103012162686500_CIT0006","doi-asserted-by":"crossref","first-page":": e45517","DOI":"10.15252\/embr.201745517","article-title":"Serum amyloid A promotes LPS clearance and suppresses LPS-induced inflammation and tissue injury","volume":"19","author":"Cheng","year":"2018","journal-title":"EMBO Rep"},{"key":"2024103012162686500_CIT0007","doi-asserted-by":"crossref","first-page":"18994","DOI":"10.1002\/jcp.28539","article-title":"Dexmedetomidine ameliorates lipopolysaccharide-induced acute kidney injury in rats by inhibiting inflammation and oxidative stress via the GSK-3\u03b2\/Nrf2 signaling pathway","volume":"234","author":"Feng","year":"2019","journal-title":"J Cell Physiol"},{"key":"2024103012162686500_CIT0008","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.intimp.2015.08.002","article-title":"Alpinetin inhibits lipopolysaccharide-induced acute kidney injury in mice","volume":"28","author":"Huang","year":"2015","journal-title":"Int Immunopharmacol"},{"key":"2024103012162686500_CIT0009","doi-asserted-by":"crossref","first-page":": BSR20201812","DOI":"10.1042\/BSR20201812","article-title":"Protective effect of anisodamine hydrobromide on lipopolysaccharide-induced acute kidney injury","volume":"40","author":"Zeng","year":"2020","journal-title":"Biosci Rep"},{"key":"2024103012162686500_CIT0010","doi-asserted-by":"crossref","first-page":"6717212","DOI":"10.1155\/2018\/6717212","article-title":"Hydrogen sulfide attenuates LPS-induced acute kidney injury by inhibiting inflammation and oxidative stress","volume":"2018","author":"Chen","year":"2018","journal-title":"Oxid Med Cell Longev"},{"key":"2024103012162686500_CIT0011","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3892\/ijmm.2020.4769","article-title":"Echinacea polysaccharide attenuates lipopolysaccharide-induced acute kidney injury via inhibiting inflammation, oxidative stress and the MAPK signaling pathway","volume":"47","author":"Shi","year":"2021","journal-title":"Int J Mol Med"},{"key":"2024103012162686500_CIT0012","doi-asserted-by":"crossref","first-page":": 5717","DOI":"10.3390\/molecules25235717","article-title":"Antioxidative, antiapoptotic, and anti-inflammatory effects of apamin in a murine model of lipopolysaccharide-induced acute kidney injury","volume":"25","author":"Kim","year":"2020","journal-title":"Molecules"},{"key":"2024103012162686500_CIT0013","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/nature25016","article-title":"Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4","volume":"552","author":"Skrott","year":"2017","journal-title":"Nature"},{"key":"2024103012162686500_CIT0014","doi-asserted-by":"crossref","first-page":"115101","DOI":"10.1088\/1361-6528\/ab5b35","article-title":"A disulfiram-loaded electrospun poly(vinylidene fluoride) nanofibrous scaffold for cancer treatment","volume":"31","author":"Xie","year":"2020","journal-title":"Nanotechnology"},{"key":"2024103012162686500_CIT0015","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.molonc.2015.02.007","article-title":"Disulfiram (DSF) acts as a copper ionophore to induce copper-dependent oxidative stress and mediate anti-tumor efficacy in inflammatory breast cancer","volume":"9","author":"Allensworth","year":"2015","journal-title":"Mol Oncol"},{"key":"2024103012162686500_CIT0016","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/s41590-020-0669-6","article-title":"FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation","volume":"21","author":"Hu","year":"2020","journal-title":"Nat Immunol"},{"key":"2024103012162686500_CIT0017","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.freeradbiomed.2020.03.007","article-title":"Disulfiram suppresses NLRP3 inflammasome activation to treat peritoneal and gouty inflammation","volume":"152","author":"Deng","year":"2020","journal-title":"Free Radic Biol Med"},{"key":"2024103012162686500_CIT0018","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12964-019-0366-y","article-title":"Oridonin protects LPS-induced acute lung injury by modulating Nrf2-mediated oxidative stress and Nrf2-independent NLRP3 and NF-\u03bab pathways","volume":"17","author":"Yang","year":"2019","journal-title":"Cell Commun Signal"},{"key":"2024103012162686500_CIT0019","doi-asserted-by":"crossref","first-page":"111488","DOI":"10.1016\/j.yexcr.2019.07.001","article-title":"NLRP3 inflammasome inhibition attenuates cisplatin-induced renal fibrosis by decreasing oxidative stress and inflammation","volume":"383","author":"Li","year":"2019","journal-title":"Exp Cell Res"},{"key":"2024103012162686500_CIT0020","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.2147\/IJN.S192382","article-title":"NLRP3 inflammasome, oxidative stress, and apoptosis induced in the intestine and liver of rats treated with titanium dioxide nanoparticles: in vivo and in vitro study","volume":"14","author":"Abbasi-Oshaghi","year":"2019","journal-title":"Int J Nanomedicine"},{"key":"2024103012162686500_CIT0021","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.cmet.2020.04.019","article-title":"Disulfiram treatment normalizes body weight in obese mice","volume":"32","author":"Bernier","year":"2020","journal-title":"Cell Metab"},{"key":"2024103012162686500_CIT0022","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1039\/C9CC09074F","article-title":"Disulfiram as a potent metallo-\u03b2-lactamase inhibitor with dual functional mechanisms","volume":"56","author":"Chen","year":"2020","journal-title":"Chem Commun (Camb)"},{"key":"2024103012162686500_CIT0023","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.antiviral.2017.12.015","article-title":"Disulfiram can inhibit MERS and SARS coronavirus papain-like proteases via different modes","volume":"150","author":"Lin","year":"2018","journal-title":"Antiviral Res"},{"key":"2024103012162686500_CIT0024","doi-asserted-by":"crossref","first-page":": 15","DOI":"10.3390\/molecules25010015","article-title":"Protopine protects mice against LPS-induced acute kidney injury by inhibiting apoptosis and inflammation via the tlr4 signaling pathway","volume":"25","author":"Zhang","year":"2019","journal-title":"Molecules"},{"key":"2024103012162686500_CIT0025","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1186\/s13054-014-0501-5","article-title":"Septic acute kidney injury: molecular mechanisms and the importance of stratification and targeting therapy","volume":"18","author":"Morrell","year":"2014","journal-title":"Crit Care"},{"key":"2024103012162686500_CIT0026","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1053\/j.ajkd.2013.11.027","article-title":"Alkaline phosphatase: a possible treatment for sepsis-associated acute kidney injury in critically ill patients","volume":"63","author":"Peters","year":"2014","journal-title":"Am J Kidney Dis"},{"key":"2024103012162686500_CIT0027","doi-asserted-by":"crossref","first-page":"919","DOI":"10.3389\/fphar.2019.00919","article-title":"Innovative drugs to target renal inflammation in sepsis: alkaline phosphatase","volume":"10","author":"H\u00fcmmeke-Oppers","year":"2019","journal-title":"Front Pharmacol"},{"key":"2024103012162686500_CIT0028","doi-asserted-by":"crossref","first-page":"e22554","DOI":"10.1002\/jbt.22554","article-title":"Local anesthetic articaine ameliorates LPS-induced acute kidney injury via inhibition of NF-\u03baB activation and the nlrp3 inflammasome pathway","volume":"34","author":"Zhao","year":"2020","journal-title":"J Biochem Mol Toxicol"},{"key":"2024103012162686500_CIT0029","first-page":"17:","article-title":"Inhibiting NLRP3 inflammasome attenuates apoptosis in contrast-induced acute kidney injury through the upregulation of HIF1A and BNIP3-mediated mitophagy","author":"Lin","year":"2021","journal-title":"Autophagy"},{"key":"2024103012162686500_CIT0030","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.imbio.2012.07.019","article-title":"Bride and groom in systemic inflammation \u2013 the bells ring for complement and Toll in cooperation","volume":"217","author":"Barratt-Due","year":"2012","journal-title":"Immunobiology"},{"key":"2024103012162686500_CIT0031","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1681\/ASN.2011020203","article-title":"Endotoxin uptake by S1 proximal tubular segment causes oxidative stress in the downstream S2 segment","volume":"22","author":"Kalakeche","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"2024103012162686500_CIT0032","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1681\/ASN.2010050484","article-title":"Sepsis and acute kidney injury","volume":"22","author":"Zarjou","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"2024103012162686500_CIT0033","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s00134-009-1723-x","article-title":"Histopathology of septic shock induced acute kidney injury: apoptosis and leukocytic infiltration","volume":"36","author":"Lerolle","year":"2010","journal-title":"Intensive Care Med"},{"key":"2024103012162686500_CIT0034","doi-asserted-by":"crossref","first-page":"109772","DOI":"10.1016\/j.biopha.2019.109772","article-title":"Flavonoid fisetin alleviates kidney inflammation and apoptosis via inhibiting Src-mediated NF-\u03baB p65 and MAPK signaling pathways in septic AKI mice","volume":"122","author":"Ren","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"2024103012162686500_CIT0035","doi-asserted-by":"crossref","first-page":"F1068","DOI":"10.1152\/ajprenal.00332.2018","article-title":"Vitamin D receptor activation protects against lipopolysaccharide-induced acute kidney injury through suppression of tubular cell apoptosis","volume":"316","author":"Du","year":"2019","journal-title":"Am J Physiol Renal Physiol"},{"key":"2024103012162686500_CIT0036","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.fitote.2014.06.005","article-title":"Leonurine ameliorates LPS-induced acute kidney injury via suppressing ROS-mediated NF-\u03baB signaling pathway","volume":"97","author":"Xu","year":"2014","journal-title":"Fitoterapia"},{"key":"2024103012162686500_CIT0037","doi-asserted-by":"crossref","first-page":"e117","DOI":"10.1097\/SHK.0000000000001306","article-title":"Effects of landiolol in lipopolysaccharide-induced acute kidney injury in rats and in vitro","volume":"52","author":"Kiyonaga","year":"2019","journal-title":"Shock"},{"key":"2024103012162686500_CIT0038","first-page":"4141","article-title":"Isoliquiritigenin attenuates LPS-induced AKI by suppression of inflammation involving NF-\u03baB pathway","volume":"10","author":"Tang","year":"2018","journal-title":"Am J Transl Res"},{"key":"2024103012162686500_CIT0039","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/s41419-018-0378-3","article-title":"Hydroxychloroquine attenuates renal ischemia\/reperfusion injury by inhibiting cathepsin mediated NLRP3 inflammasome activation","volume":"9","author":"Tang","year":"2018","journal-title":"Cell Death Dis"},{"key":"2024103012162686500_CIT0040","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1681\/ASN.2016020177","article-title":"Of inflammasomes and alarmins: IL-1\u03b2 and IL-1\u03b1 in kidney disease","volume":"27","author":"Anders","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"2024103012162686500_CIT0041","doi-asserted-by":"crossref","first-page":"2386068","DOI":"10.1155\/2016\/2386068","article-title":"Thioredoxin-interacting protein mediates NLRP3 inflammasome activation involved in the susceptibility to ischemic acute kidney injury in diabetes","volume":"2016","author":"Xiao","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"2024103012162686500_CIT0042","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1681\/ASN.2010020143","article-title":"The NLRP3 inflammasome promotes renal inflammation and contributes to CKD","volume":"21","author":"Vilaysane","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"2024103012162686500_CIT0043","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/imr.12286","article-title":"Initiation and perpetuation of NLRP3 inflammasome activation and assembly","volume":"265","author":"Elliott","year":"2015","journal-title":"Immunol Rev"},{"key":"2024103012162686500_CIT0044","doi-asserted-by":"crossref","first-page":"787","DOI":"10.4049\/jimmunol.0901363","article-title":"Cutting edge: NF-\u03baB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression","volume":"183","author":"Bauernfeind","year":"2009","journal-title":"J Immunol"},{"key":"2024103012162686500_CIT0045","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s11064-015-1760-5","article-title":"Ethanol-induced TLR4\/NLRP3 neuroinflammatory response in microglial cells promotes leukocyte infiltration across the BBB","volume":"41","author":"Alfonso-Loeches","year":"2016","journal-title":"Neurochem Res"},{"key":"2024103012162686500_CIT0046","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/cmi.2015.95","article-title":"Molecular mechanisms regulating NLRP3 inflammasome activation","volume":"13","author":"Jo","year":"2016","journal-title":"Cell Mol Immunol"},{"key":"2024103012162686500_CIT0047","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1001\/jama.1986.03380110055026","article-title":"Disulfiram treatment of alcoholism. A Veterans Administration cooperative study","volume":"256","author":"Fuller","year":"1986","journal-title":"JAMA"},{"key":"2024103012162686500_CIT0048","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.2174\/138161207782110390","article-title":"Targeting of nuclear factor-\u03baB and proteasome by dithiocarbamate complexes with metals","volume":"13","author":"Cvek","year":"2007","journal-title":"Curr Pharm Des"}],"container-title":["Journal of Pharmacy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/74\/2\/259\/60219081\/rgab171.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/74\/2\/259\/60219081\/rgab171.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T16:57:28Z","timestamp":1730307448000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpp\/article\/74\/2\/259\/6470026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,1]]},"references-count":48,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,2,1]]},"published-print":{"date-parts":[[2022,2,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jpp\/rgab171","relation":{},"ISSN":["0022-3573","2042-7158"],"issn-type":[{"value":"0022-3573","type":"print"},{"value":"2042-7158","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,2,1]]},"published":{"date-parts":[[2022,2,1]]}}}