{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:26:51Z","timestamp":1792794411046,"version":"4.5.0"},"reference-count":82,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"National Research Foundation-The World Academy of Science (NRF-TWAS), Pretoria","award":["116106"],"award-info":[{"award-number":["116106"]}],"id":[{"id":"https:\/\/ror.org\/00twbd828","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The antidiabetic potential of caffeic acid in fructose\/streptozotocin-induced type 2 diabetic rats was examined in this study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Male Sprague-Dawley rats were supplied with 10% fructose solution for 14 days followed by an intraperitoneal injection of 40 mg\/kg bw streptozotocin to induce type 2 diabetes (T2D). Rats were treated with both low (150 mg\/kg bw) and high (300 mg\/kg bw) doses of caffeic acid for 5 weeks, while the positive control group was treated with metformin (200 mg\/kg bw).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key findings<\/jats:title>\n                    <jats:p>Treatment with caffeic acid significantly decreased blood glucose levels and elevated serum insulin levels while improving glucose tolerance, pancreatic \u03b2-cell function and morphology. It also led to a significant reduction of serum cholesterol, triglyceride, LDL-cholesterol, ALT, AST, creatinine, urea and uric acid levels, while increasing HDL cholesterol levels. Caffeic acid significantly (P &amp;lt; 0.05) elevated hepatic glycogen level, serum and pancreatic glutathione level, superoxide dismutase and catalase activities with a concomitant decrease in malondialdehyde level, \u03b1-amylase, lipase, adenosine triphosphatase (ATPase), ectonucleoside triphosphate diphosphohydrolase (ENTPDase), 5\u02b9-nucleotidase (5\u02b9-NTD) and acetylcholinesterase activities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The results suggest caffeic acid as a potent natural product with therapeutic effects against T2D. Further molecular and clinical studies are, however, required to ascertain these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jpp\/rgac021","type":"journal-article","created":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T16:11:31Z","timestamp":1647965491000},"page":"973-984","source":"Crossref","is-referenced-by-count":31,"title":["Caffeic acid regulates glucose homeostasis and inhibits purinergic and cholinergic activities while abating oxidative stress and dyslipidaemia in fructose-streptozotocin-induced diabetic rats"],"prefix":"10.1093","volume":"74","author":[{"given":"Veronica F","family":"Salau","sequence":"first","affiliation":[{"name":"Department of Biochemistry, School of Life Sciences, University of KwaZulu-Natal (Westville Campus) , Durban ,","place":["South Africa"]},{"name":"Department of Biochemistry, Veritas University , Bwari, Abuja ,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0489-338X","authenticated-orcid":false,"given":"Ochuko L","family":"Erukainure","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Life Sciences, University of KwaZulu-Natal (Westville Campus) , Durban ,","place":["South Africa"]},{"name":"Department of Pharmacology, University of the Free State , Bloemfontein ,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omamuyovwi M","family":"Ijomone","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy, Federal University of Technology Akure , Akure ,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0309-9491","authenticated-orcid":false,"given":"Md. 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