{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T10:54:47Z","timestamp":1785581687916,"version":"3.56.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"The Scientific and Technological Research Council of T\u00fcrkiye"},{"name":"Foundation of Marmara University School of Medicine"},{"name":"Abdi Ibrahim Pharmaceutical Ltd"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Phoenixin-14 (PNX) is a neuropeptide that has been shown to prevent oxidative damage and stimulates insulin secretion. We investigated the effects of PNX on pancreatic injury induced by streptozotocin (STZ), and nicotinamide (NAD). Male Sprague-Dawley rats, in control (C) and diabetic (STZ) groups, were treated with either saline, or PNX (0.45 nmol\/kg, or 45 nmol\/kg) daily for 3 days 1 week after STZ injection. Fasting blood glucose (FBG) and gastric emptying rate (GER) were measured. Tissue and blood samples were collected. PNX treatments prevented pancreatic damage and \u03b2 cell loss. Increased luminol and lucigenin levels in the pancreas, ileum and liver tissues of STZ groups were alleviated by PNX treatment in pancreatic and ileal tissues. PNX0.45 decreased FBG without any change in insulin blood level and pancreatic mRNA. GER increased in all diabetic rats while PNX0.45 delayed GER only in the C group. PNX diminishes pancreatic damage and lowers FBG by reducing oxidative load.<\/jats:p>","DOI":"10.1093\/jpp\/rgac055","type":"journal-article","created":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T19:18:00Z","timestamp":1663787880000},"page":"1651-1659","source":"Crossref","is-referenced-by-count":5,"title":["Phoenixin 14 ameloriates pancreatic injury in streptozotocin-induced diabetic rats by alleviating oxidative burden"],"prefix":"10.1093","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9485-0174","authenticated-orcid":false,"given":"Zarife Nig\u00e2r","family":"Ozdemir-Kumral","sequence":"first","affiliation":[{"name":"Department of Physiology, Marmara University School of Medicine , Istanbul ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eminenur","family":"Sen","sequence":"additional","affiliation":[{"name":"Marmara University School of Medicine , Istanbul 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Istanbul ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3006-2061","authenticated-orcid":false,"given":"Leyla Semiha","family":"Sen","sequence":"additional","affiliation":[{"name":"Department of Physiology, Marmara University School of Medicine , Istanbul ,","place":["Turkey"]},{"name":"Department of General Surgery, Marmara University School of Medicine , Istanbul ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Kanpalta Mustafao\u011flu","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Marmara University School of Medicine , Istanbul ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meral","family":"Yuksel","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Technics, Marmara University Vocational School of Health Services , Istanbul 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