{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T23:16:04Z","timestamp":1786662964245,"version":"build-2736575974"},"reference-count":185,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T00:00:00Z","timestamp":1663200000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Shaanxi Province","award":["2022SF-254; 2019ZDLSF04-03-02"],"award-info":[{"award-number":["2022SF-254; 2019ZDLSF04-03-02"]}]},{"name":"Subject Innovation Team of Shaanxi University of Chinese Medicine","award":["2019-YL12"],"award-info":[{"award-number":["2019-YL12"]}]},{"name":"Natural Science Basic Research Project of Department of science and technology of Shaanxi Province","award":["2021JQ-744"],"award-info":[{"award-number":["2021JQ-744"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The genus Reynoutria belonging to the family Polygonaceae is widely distributed in the north temperate zone and used in folk medicine. It is administered as a sedative, tonic and digestive, also as a treatment for canities and alopecia. Herein, we reported a review on traditional uses, phytochemistry and pharmacology reported from 1985 up to early 2022. All the information and studies concerning Reynoutria plants were summarized from the library and digital databases (e.g. ScienceDirect, SciFinder, Medline PubMed, Google Scholar, and CNKI).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>A total of 185 articles on the genus Reynoutria have been collected. The phytochemical investigations of Reynoutria species revealed the presence of more than 277 chemical components, including stilbenoids, quinones, flavonoids, phenylpropanoids, phospholipids, lactones, phenolics and phenolic acids. Moreover, the compounds isolated from the genus Reynoutria possess a wide spectrum of pharmacology such as anti-atherosclerosis, anti-inflammatory, antioxidative, anticancer, neuroprotective, anti-virus and heart protection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>In this paper, the traditional uses, phytochemistry and pharmacology of genus Reynoutria were reviewed. As a source of traditional folk medicine, the Reynoutria genus have high medicinal value and they are widely used in medicine. Therefore, we hope our review can help genus Reynoutria get better development and utilization.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpp\/rgac068","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T13:35:19Z","timestamp":1663248919000},"page":"1718-1742","source":"Crossref","is-referenced-by-count":8,"title":["A comprehensive review of traditional uses, phytochemistry and pharmacology of <i>Reynoutria<\/i> genus"],"prefix":"10.1093","volume":"74","author":[{"given":"Zi-Long","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Pharmacy, Shaanxi University of Chinese Medicine , Xian Yang, Shaanxi 712046 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ze","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shaanxi University of Chinese Medicine , Xian Yang, Shaanxi 712046 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Qing","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shaanxi University of Chinese Medicine , Xian Yang, Shaanxi 712046 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Dong","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shaanxi University of Chinese Medicine , Xian Yang, Shaanxi 712046 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Deng","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shaanxi University of Chinese Medicine , Xian Yang, Shaanxi 712046 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Min","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences , BeiJing 100700 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Mei","family":"Song","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shaanxi University of Chinese Medicine , Xian Yang, Shaanxi 712046 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shaanxi University of Chinese Medicine , Xian Yang, Shaanxi 712046 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,9,15]]},"reference":[{"key":"2024103012195511100_CIT0001","first-page":"192","article-title":"Advances in chemical constituents and pharmacological effects of Polygonum multiflora","volume":"25","author":"Wang","year":"2019","journal-title":"Chin J Exp Med Form"},{"key":"2024103012195511100_CIT0002","first-page":"906","article-title":"The structure and cardiovascular activity of a new tetrahydroxystilbene glycoside from Polygonum multiflora","volume":"35","author":"Chen","year":"2000","journal-title":"Chin J Pharmaceutical Sci"},{"key":"2024103012195511100_CIT0003","first-page":"3252","article-title":"Study on the chemical composition of Chinese medicine Fallopia multiflora","volume":"41","author":"Zhang","year":"2016","journal-title":"Chin J Chin Mater Med"},{"key":"2024103012195511100_CIT0004","first-page":"1441","article-title":"A new chromogenic ketone glycoside from Fallopia multiflora","volume":"39","author":"Zhao","year":"2014","journal-title":"Chin J Chin Mater Med"},{"key":"2024103012195511100_CIT0005","first-page":"109","article-title":"Effects of rhodopsin in prepared Fallopia multiflora on JAK2\/STAT3 pathway in ApoE\u2212\/\u2212 mice atherosclerosis model","volume":"24","author":"Li","year":"2018","journal-title":"Chin J Exp Tradit Med Form"},{"key":"2024103012195511100_CIT0006","volume-title":"Study on Chemical Composition and its Biological Activity of Fallopia multiflora var. 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