{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T23:50:52Z","timestamp":1788047452953,"version":"build-2784847793"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Dokuz Eylul University Scientific Research Projects Coordination Unit","award":["2020.KB.SAG.045"],"award-info":[{"award-number":["2020.KB.SAG.045"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The aim of this study is to evaluate the protective effect of nicorandil, a selective mitochondrial KATP channel opener, on QT prolongation and myocardial damage induced by amitriptyline.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The dose of amitriptyline (intraperitoneal, i.p.) that prolong the QT interval was found 75 mg\/kg. Rats were randomized into five groups the control group, amitriptyline group, nicorandil (selective mitochondrial KATP channel opener, 3 mg\/kg i.p.) + amitriptyline group, 5-hdyroxydecanoate (5-HD, selective mitochondrial KATP channel blocker, 10 mg\/kg i.p.) + amitriptyline group and 5-HD + nicorandil + amitriptyline group. Cardiac parameters, biochemical and histomorphological\/immunohistochemical examinations were evaluated. p &amp;lt; 0.05 was accepted as statistically significant.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>Amitriptyline caused statistically significant prolongation of QRS duration, QT interval and QTc interval (p &amp;lt; 0.05). It also caused changes in tissue oxidant (increase in malondialdehyde)\/anti-oxidant (decrease in glutathione peroxidase) parameters (p &amp;lt; 0.05), myocardial damage and apoptosis (p &amp;lt; 0.01 and p &amp;lt; 0.001). While nicorandil administration prevented amitriptyline-induced QRS, QT, QTc prolongation (p &amp;lt; 0.05), myocardial damage and apoptosis (p &amp;lt; 0.05), it did not affect the changes in oxidative parameters (p &amp;gt; 0.05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our results suggest that nicorandil, a selective mitochondrial KATP channel opener, plays a protective role in amitriptyline-induced QT prolongation and myocardial damage. Mitochondrial KATP channel opening and anti-apoptotic effects may play a role in the cardioprotective effect of nicorandil.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpp\/rgac089","type":"journal-article","created":{"date-parts":[[2022,12,17]],"date-time":"2022-12-17T07:17:00Z","timestamp":1671261420000},"page":"415-426","source":"Crossref","is-referenced-by-count":2,"title":["Effect of the selective mitochondrial KATP channel opener nicorandil on the QT prolongation and myocardial damage induced by amitriptyline in rats"],"prefix":"10.1093","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1606-3164","authenticated-orcid":false,"given":"Orhan","family":"Sahin","sequence":"first","affiliation":[{"name":"Dokuz Eylul University, School of Medicine, Department of Medical Pharmacology , Izmir 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