{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:47:36Z","timestamp":1791863256355,"version":"4.3.4"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100005076","name":"Agricultural Research Development Agency","doi-asserted-by":"publisher","award":["CRP6305030450"],"award-info":[{"award-number":["CRP6305030450"]}],"id":[{"id":"10.13039\/501100005076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002873","name":"Chulalongkorn University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002873","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Laboratory Animal Centre"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The study compared the protective effects against indomethacin-induced GI ulceration of chlorogenic acid with quercetin in rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Rats were orally given chlorogenic acid or quercetin (100 mg\/kg; 5 days), followed by indomethacin (40 mg\/kg; single dose). After 24 h, GI tissues were assessed for histopathological damages, then analysed by ELISA and western blot methods. Cell viability was measured in vitro by MTT assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key findings<\/jats:title>\n                    <jats:p>Unlike quercetin, chlorogenic acid could not prevent gastric ulcers in indomethacin-treated rats. The levels of gastric prostaglandin E2 (PGE2) and Bax\/Bcl-2 ratio in the chlorogenic acid-treated group were not different from those receiving indomethacin alone. Nevertheless, both compounds alleviated jejunum ulcers through suppression of PERK\/eIF-2\/ATF-4\/CHOP-related endoplasmic reticulum (ER) stress and decrease Bax\/Bcl-2 ratio. Moreover, at 100 \u00b5M, they abolished the cytotoxicity of tunicamycin (an ER stress inducer) in gastric (AGS) and intestinal (Caco-2) cells. In silico docking studies suggested that both compounds could interact with key amino acid residues in the \u00adcatalytic domain of PERK.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Chlorogenic acid and quercetin exerted comparable protective effects against indomethacin-induced intestinal ulcer through suppression of ER stress-mediated apoptosis but, unlike quercetin, chlorogenic acid offered no protection against gastric ulceration due to its \u00adinability to increase PGE2 production.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jpp\/rgac098","type":"journal-article","created":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T00:14:15Z","timestamp":1670285655000},"page":"427-436","source":"Crossref","is-referenced-by-count":16,"title":["Different protective capability of chlorogenic acid and quercetin against indomethacin-induced gastrointestinal ulceration"],"prefix":"10.1093","volume":"75","author":[{"given":"Cherdsak","family":"Boonyong","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University , Bangkok 10330 ,","place":["Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wannee","family":"Angkhasirisap","sequence":"additional","affiliation":[{"name":"Academic Service Division, National Laboratory Animal Center, Mahidol University , Nakorn Pathom 73170 ,","place":["Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanchana","family":"Kengkoom","sequence":"additional","affiliation":[{"name":"Academic Service Division, National Laboratory Animal Center, Mahidol University , Nakorn Pathom 73170 ,","place":["Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suree","family":"Jianmongkol","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University , Bangkok 10330 ,","place":["Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,3,1]]},"reference":[{"key":"2024103012213124800_CIT0001","first-page":"190","article-title":"The Mexican consensus on the diagnosis, treatment, and prevention of NSAID-induced gastropathy and enteropathy","volume":"85","author":"Bielsa-Fern\u00e1ndez","year":"2020","journal-title":"Rev Gastroenterol Mex (Engl Ed)"},{"key":"2024103012213124800_CIT0002","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/9781119211419.ch6","article-title":"Nonsteroidal anti-inflammatory drug-gastropathy and enteropathy.","volume-title":"Evidence-based Gastroenterology and Hepatology","author":"Kyaw","year":"2019","edition":"4th 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