{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T18:38:36Z","timestamp":1785609516227,"version":"3.56.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100015401","name":"Key Research and Development Projects of Shaanxi Province","doi-asserted-by":"publisher","award":["2019GSF108260"],"award-info":[{"award-number":["2019GSF108260"]}],"id":[{"id":"10.13039\/501100015401","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015507","name":"Shandong First Medical University","doi-asserted-by":"publisher","award":["2019QL010"],"award-info":[{"award-number":["2019QL010"]}],"id":[{"id":"10.13039\/501100015507","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015507","name":"Shandong First Medical University","doi-asserted-by":"publisher","award":["2019QL013"],"award-info":[{"award-number":["2019QL013"]}],"id":[{"id":"10.13039\/501100015507","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>This study was aimed to evaluate the protective effects of phenylethanoid glycosides extract from Cistanche deserticola against atherosclerosis and its molecular mechanism.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Total phenylethanoid glycosides were extracted and purified from C. deserticola, and the C. deserticola extract (CDE) was used to treat a mice model of atherosclerosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>CDE containing 81.00% total phenylethanoid glycosides, with the contents of echinacoside and acteoside being 31.36% and 7.23%, respectively. A 13-week of CDE supplementation (1000 mg\/kg body weight\/day) significantly reduced atherosclerotic lesions in the aortic sinus and entire aorta in ApoE\u2212\/\u2212 mice fed with a high-fat diet. In addition, varying doses of CDE (250, 500 and 1000 mg\/kg body weight\/day) lowered plasma total cholesterol, triglyceride and non-high-density lipoprotein cholesterol levels. Transcriptomic analysis of the small intestine revealed the changes enriched in cholesterol metabolic pathway and the activation of Abca1 gene. Further validation using real-time quantitative PCR and western blot confirmed that CDE significantly increased the mRNA levels and protein expressions of ABCA1, LXR\u03b1 and PPAR\u03b3.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our results demonstrate the beneficial effects of C. deserticola on atherosclerotic plaques and lipid homeostasis, and it is, at least partially, by activating PPAR\u03b3-LXR\u03b1-ABCA1 pathway in small intestine.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpp\/rgad015","type":"journal-article","created":{"date-parts":[[2023,2,25]],"date-time":"2023-02-25T13:23:01Z","timestamp":1677331381000},"page":"677-685","source":"Crossref","is-referenced-by-count":7,"title":["Phenylethanoid glycosides extract from <i>Cistanche deserticola<\/i> ameliorates atherosclerosis in apolipoprotein E-deficient mice and regulates intestinal PPAR\u03b3-LXR\u03b1-ABCA1 pathway"],"prefix":"10.1093","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1584-5113","authenticated-orcid":false,"given":"Xiubin","family":"Jia","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences , Tai\u2019an, Shandong Province ,","place":["People\u2019s Republic of China"]},{"name":"The Second Affiliated Hospital of Shandong First Medical University , Tai\u2019an, Shandong Province ,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyan","family":"Liu","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Shandong First Medical University , Tai\u2019an, Shandong Province ,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junli","family":"Xue","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Shandong First Medical University , Tai\u2019an, Shandong Province ,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunchao","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences , Tai\u2019an, Shandong Province ,","place":["People\u2019s Republic of China"]},{"name":"The Second Affiliated Hospital of Shandong First Medical University , Tai\u2019an, Shandong Province ,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjun","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Shandong First Medical University , Tai\u2019an, Shandong Province ,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shucun","family":"Qin","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Shandong First Medical University , Tai\u2019an, Shandong Province ,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences , Tai\u2019an, Shandong Province ,","place":["People\u2019s Republic of China"]},{"name":"The Second Affiliated Hospital of Shandong First Medical University , Tai\u2019an, Shandong Province ,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,5,1]]},"reference":[{"key":"2024103012212894900_CIT0001","first-page":"573","article-title":"T. 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