{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T05:33:14Z","timestamp":1777267994850,"version":"3.51.4"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Nephrotic syndrome (NS) remains a therapeutic challenge for nephrologists. Piceatannol-3\u02b9-O-\u03b2-d-glucopyranoside (PG) is a major active ingredient in Quzha. The purpose of the study was to assess the renoprotection of PG.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In vitro, the podocyte protection of PG was assessed in MPC-5. SD rats were injected with adriamycin to induce nephropathy in vivo. The determination of biochemical changes and inflammatory cytokines was performed, and pathological changes were examined by histopathological examination. Immunostaining and western blot analyses were used to analyse expression levels of proteins.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>The results showed that PG improved adriamycin-induced podocyte injury, attenuated nephropathy, improved hypoalbuminemia and hyperlipidaemia, and lowered cytokine levels. The podocyte protection of PG was further verified by reduction of desmin and increasing synaptopodin expression. Furthermore, treatment with PG down-regulated the expression of HMGB1, TLR4 and NF-\u03baB along with its upstream regulator, IKK\u03b2 and yet up-regulated I\u03baB\u03b1 expression by western blot analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Overall, our data showed that PG has a favourable renoprotection in experimental nephrosis, apparently by amelioration of podocyte injury. PG might mediate these effects via modulation of the HMGB1\/TLR4\/NF-\u03baB signalling pathway. The study first provides a promising leading compound for the treatment of NS.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpp\/rgad021","type":"journal-article","created":{"date-parts":[[2023,3,25]],"date-time":"2023-03-25T11:26:56Z","timestamp":1679743616000},"page":"693-702","source":"Crossref","is-referenced-by-count":3,"title":["Piceatannol-3\u02b9-O-\u03b2-<scp>d<\/scp>-glucopyranoside alleviates nephropathy via regulation of High mobility group B-1 (HMGB1)\/Toll-like receptor 4 (TLR4)\/Nuclear factor kappa B (NF-\u03baB) signalling pathway"],"prefix":"10.1093","volume":"75","author":[{"given":"Shi-Hao","family":"Du","sequence":"first","affiliation":[{"name":"School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University , Yantai ,","place":["PR China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Yan","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University , Yantai ,","place":["PR China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai-Lin","family":"Gan","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University , Yantai ,","place":["PR China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ze-Yu","family":"Song","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University , Yantai ,","place":["PR China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng-Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University , Yantai ,","place":["PR China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen-Yuan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University , Yantai ,","place":["PR China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Liu","sequence":"additional","affiliation":[{"name":"Shandong Boyuan Biomedical Co., Ltd. , Yantai ,","place":["PR China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Yu-Huang-Ding Hospital\/Qingdao University , Yantai, Shandong ,","place":["PR China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6245-7450","authenticated-orcid":false,"given":"Hua-Ying","family":"Fan","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech 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