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Body weight, blood pressure (BP), renal weight, renal function and renal morphology were measured. Further, western blotting and immunohistochemical analysis were used to study the underlying mechanism.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>Compared with the WKY group, plasmatic levels of renin, angiotensin II (Ang-II), transforming growth factor beta 1(TGF-\u03b21), plasminogen activator inhibitor-1(PAI-1), creatinine (Cr), blood urea nitrogen (BUN), renal index, mRNA levels of ERK1\/2 and \u03b1-SMA were significantly increased in SHR. Histology results showed that renal tubular injury and tubulointerstitial fibrosis occurred in SHR. After administration, SBP of captopril group decreased at each week after administration, especially at 3, 5, 6 7 and 8 weeks (P &amp;lt; 0.05 or P &amp;lt; 0.01). There is no significant effect was assessed in the olive oil group. Decreased plasma Cr, Renin, Ang-II, TGF-\u03b21, PAI-1, SCFAs and Renin, TGF-\u03b21, PAI-1 in renal tissues were observed significantly in captopril (P &amp;lt;0.05 or P &amp;lt; 0.01). Plasma BUN, Ang-II, TGF-\u03b21 and PAI-1 in renal tissues decreased in the olive oil group significantly (P &amp;lt;0.05 or P &amp;lt; 0.01). PA (80, 40 and 20 mg\/kg) lowered BP and plasmatic levels of Renin, Ang-II, TGF-\u03b21 and PAI-1. Treatment with PA (40, 20 mg\/kg) decreased levels of Cr, BUN and suppressed of activation of pro-fibrosis cytokines including TGF-\u03b21 in kidney. There is no ameliorative change in the olive oil group and the captopril group (P &amp;gt; 0.05) while PA treatment alleviated renal tubular injury and produced dramatic collagen fibre area reductions in mesangial membrane, basement membrane, and renal interstitium obviously (P &amp;lt; 0.05 or P &amp;lt; 0.01). Treatment of SHR with PA-inhibited MFB activation and downregulated mRNA of \u03b1-SMA. Treatment with PA suppressed excessive production of the extracellular matrix (ECM) via decreasing Col I, III and FN, downregulating mRNA of tissue inhibitor of TIMP-1 along with upregulating mRNA of MMP-9. The expression of Col III and MMP-9 mRNA-reduced in the captopril group (P &amp;lt; 0.05). In addition, the expression of ERK1\/2 and pERK1\/2 also reduced in the captopril group significantly (P &amp;lt; 0.05 or P &amp;lt; 0.01). Treatment with PA (20 mg\/kg) downregulated proteins expression of Raf-1, ERK1\/2 and pERK1\/2 and mRNA expression of Ras, Raf-1 and ERK1\/2.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Overall, PA restored normal BP, alleviated renal dysfunction and renal fibrosis, possibly by suppressing Ang II and TGF-\u03b21-mediated Ras\/Raf-1\/ERK1\/2 signalling pathway.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpp\/rgad032","type":"journal-article","created":{"date-parts":[[2023,5,13]],"date-time":"2023-05-13T09:49:52Z","timestamp":1683971392000},"page":"995-1010","source":"Crossref","is-referenced-by-count":10,"title":["Patchouli alcohol against renal fibrosis of spontaneously hypertensive rats via Ras\/Raf-1\/ERK1\/2 signalling pathway"],"prefix":"10.1093","volume":"75","author":[{"given":"Jing","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Southwestern Chinese Medicine Resources, Key Laboratory of standardization of Chinese herbal medicine of MOE, Chengdu University of Traditional Chinese Medicine , Chengdu ,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanying","family":"Hu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Southwestern Chinese Medicine Resources, Key Laboratory of standardization of Chinese herbal medicine of MOE, Chengdu University of Traditional Chinese Medicine , Chengdu ,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxiu","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Southwestern Chinese Medicine Resources, Key Laboratory of standardization of Chinese herbal medicine of MOE, Chengdu University of Traditional Chinese Medicine , Chengdu ,","place":["PR 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Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University , Chengdu ,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9892-1518","authenticated-orcid":false,"given":"Xie","family":"Xiaofang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Southwestern Chinese Medicine Resources, Key Laboratory of standardization of Chinese herbal medicine of MOE, Chengdu University of Traditional Chinese Medicine , Chengdu ,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Peng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Southwestern Chinese Medicine Resources, Key Laboratory of standardization of Chinese herbal medicine of MOE, Chengdu University of Traditional Chinese Medicine , Chengdu ,","place":["PR 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