{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T06:53:57Z","timestamp":1785826437191,"version":"3.56.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100010877","name":"Shenzhen Science and Technology Innovation Commission","doi-asserted-by":"publisher","award":["JCYJ20200109150717745 XY"],"award-info":[{"award-number":["JCYJ20200109150717745 XY"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010877","name":"Shenzhen Science and Technology Innovation Commission","doi-asserted-by":"publisher","award":["JCYJ20200109144418639"],"award-info":[{"award-number":["JCYJ20200109144418639"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shenzhen Key Medical Discipline Construction","award":["SZXK069"],"award-info":[{"award-number":["SZXK069"]}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"publisher","award":["SZSM201611090"],"award-info":[{"award-number":["SZSM201611090"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019404","name":"Shenzhen-Hong Kong Institute of Brain Science","doi-asserted-by":"publisher","award":["NYKFKT20190019"],"award-info":[{"award-number":["NYKFKT20190019"]}],"id":[{"id":"10.13039\/501100019404","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shenzhen Fundamental Research Institutions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>We aimed to elucidate the therapeutic potential of Chrysin (CN) against the high-fat diet (HFD) induced non-alcoholic fatty liver disease (NAFLD) and its mechanism.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>To assess the hypothesis, NAFLD was induced in C57BL\/6 mice by feeding a high-fat diet for up to two months, followed by CN administration (for three months). Liver injury\/toxicity, lipid deposition, inflammation and fibrosis were detected via molecular and biochemical analysis, including blood chemistry, immunoimaging and immunoblotting. Moreover, we performed proteomic analysis to illuminate Chrysin\u2019s therapeutic effects further.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>CN treatment significantly reduced liver-fat accumulation and inflammation, ultimately improving obesity and liver injury in NAFLD mice. Proteomic analysis showed that CN modified the protein expression profiles in the liver, particularly improving the expression of proteins related to energy, metabolism and inflammation. Mechanistically, CN treatment increased AMP-activated protein and phosphorylated CoA (P-ACC). Concurrently, it reduced inflammation and inflammation activation by inhibiting NLRP3 expression.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In summary, CN treatment reduced lipid metabolism by AMPK and inflammasome activation by NLRP3 inhibition, ultimately improving NAFLD progression. These findings suggest that CN could be a potential treatment candidate for the NFLAD condition.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpp\/rgad041","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T19:19:43Z","timestamp":1683832783000},"page":"1086-1099","source":"Crossref","is-referenced-by-count":13,"title":["Chrysin prevents inflammation-coinciding liver steatosis via AMPK signalling"],"prefix":"10.1093","volume":"75","author":[{"given":"Chuanyue","family":"Gao","sequence":"first","affiliation":[{"name":"School of Public Health, Shanxi Medical University , Taiyuan ,","place":["China"]},{"name":"Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology (2020\u20132024), Shenzhen Center for Disease Control and Prevention , Shenzhen 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