{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:48:20Z","timestamp":1790383700316,"version":"4.1.0"},"reference-count":182,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Morinda officinalis How oligosaccharide (MOO) stands as one of the principal active constituents of M. officinalis How, widely employed in traditional Chinese medicine. The methods for MOO extraction predominantly encompass hot water extraction, ethanol extraction, ultrasonic-assisted extraction, and microwave-assisted extraction. Distinct extraction techniques yield varying MOO quantities. MOO encompasses a diversity of oligosaccharides, including bajijiasu, sucrose, 1-kestose, nystose, mannose, 1F-fructofuranosylnystose, 1,1,1,1-kestohexose, fructoheptasaccharide, inulin-type hexasaccharide, inulin-type heptasaccharide, inulotriose, inulotetraose, inulopentaose, and mannose. MOO exhibits a wide spectrum of biological activities, exerting specific effects on the nervous system, cardiovascular system, motor system, reproductive system, and immune system. It demonstrates antidepressant properties, offers potential in mitigating Alzheimer\u2019s disease, stimulates angiogenesis, and possesses anti-osteoporotic and other pharmacological effects. Clinically, when combined with various antidepressants, MOO exhibits specific therapeutic efficacy across multiple forms of depression. As a naturally occurring plant oligosaccharide, MOO holds diverse pharmaceutical applications. This article conducts a review of the latest extraction and purification methodologies, structural characterization analysis, biological activity assessment, and clinical applications of MOO. Such a comprehensive analysis yields innovative insights for advancing the research and application of MOO in the future.<\/jats:p>","DOI":"10.1093\/jpp\/rgad096","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T20:01:22Z","timestamp":1700683282000},"page":"437-461","source":"Crossref","is-referenced-by-count":12,"title":["Isolation, phytochemistry, characterization, biological activity, and application of <i>Morinda officinalis<\/i> How oligosaccharide: a review"],"prefix":"10.1093","volume":"76","author":[{"given":"Jiahui","family":"Yue","sequence":"first","affiliation":[{"name":"School of Pharmacy, Ningxia Medical University , Yinchuan 750004 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxin","family":"Xia","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Ningxia Medical University , Yinchuan 750004 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushu","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Ningxia Medical University , Yinchuan 750004 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Ningxia Medical University , Yinchuan 750004 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Ningxia Medical University , Yinchuan 750004 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Ningxia Medical University , Yinchuan 750004 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Ningxia Medical University , Yinchuan 750004 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cunbing","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Ningxia Medical University , Yinchuan 750004 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Ningxia Medical University , Yinchuan 750004 ,","place":["China"]},{"name":"Ningxia Minority Medicine Modernization Key Laboratory of Ministry of Education , Yinchuan 75004 ,","place":["China"]},{"name":"College of Traditional Chinese Medicine, Ningxia Medical University , Yinchuan 75004 ,","place":["China"]},{"name":"Key Laboratory of Ministry of Education of TCM prevention and treatment of high-incidence diseases in NingXia , Yinchuan 75004 ,","place":["China"]},{"name":"Key Laboratory of Study on Integrated Traditional Chinese and Western Medicine with high incidence diseases in Ningxia , Yinchuan 75004 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyan","family":"Fu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Ningxia Medical University , Yinchuan 750004 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,1]]},"reference":[{"key":"2024103012043380400_CIT0001","first-page":"1037","article-title":"Mechanisms of action of prebiotics and their effects on gastro-intestinal disorders in adults","volume-title":"Nutrients","author":"Guarino","year":"2020"},{"key":"2024103012043380400_CIT0002","first-page":"8828","article-title":"Effects of combinations of goat milk and oligosaccharides on altering the microbiota, immune 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