{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T06:10:20Z","timestamp":1776060620187,"version":"3.50.1"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Ministry of Education in Saudi Arabia","award":["IFKSUDR-H150"],"award-info":[{"award-number":["IFKSUDR-H150"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Diabetic cardiomyopathy is a known complication of diabetes mellitus. Herein, we aimed to determine whether glycemic control mediated by sitagliptin, a dipeptidyl peptidase-4 inhibitor, can ameliorate diabetic myocardial abnormalities by modulating TGF-\u03b2 signaling via the SMAD and integrin-linked kinase (ILK) pathways.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Four groups of male Wistar albino rats were used, with six rats in each group. Two nondiabetic and two diabetic (produced by a single intraperitoneal dose of streptozotocin (55 mg\/kg)) groups were administered either normal saline or sitagliptin (100 mg\/kg) orally for 6 weeks. Subsequently, HW\/BW ratios and cardiac enzymes were assessed, along with a histological examination of cardiac tissues. Levels of TGF-\u03b2, collagen I, p-SMAD2\/3, TNF-\u03b1, MMP-9, and ILK were detected.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Compared with the diabetic control group, sitagliptin-treated diabetic rats exhibited considerably reduced HW\/BW ratios and troponin I and creatine kinase-MB levels, with improvements in histopathological changes in cardiac tissues. TGF-\u03b2, collagen I, p-SMAD2\/3, TNF-\u03b1, and MMP-9 levels were significantly decreased in the sitagliptin-treated diabetic group, whereas ILK was elevated following sitagliptin treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Sitagliptin could afford cardioprotective effects for the first time by altering ILK-associated TGF-\u03b2\/SMAD signaling pathways. Thus, sitagliptin may be a promising therapeutic target for the prevention of diabetic cardiomyopathy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpp\/rgad111","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T20:32:47Z","timestamp":1700685167000},"page":"64-73","source":"Crossref","is-referenced-by-count":8,"title":["Role of the integrin-linked kinase\/TGF-\u03b2\/SMAD pathway in sitagliptin-mediated cardioprotective effects in a rat model of diabetic cardiomyopathy"],"prefix":"10.1093","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7138-414X","authenticated-orcid":false,"given":"Anfal F","family":"Bin Dayel","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University , Riyadh ,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3367-002X","authenticated-orcid":false,"given":"Asma S","family":"Alonazi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University , Riyadh ,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nawal M","family":"Alrasheed","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University , Riyadh ,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maha A","family":"Alamin","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University , Riyadh ,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wedad S","family":"Sarawi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University , Riyadh ,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abeer O","family":"Alharbi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University , Riyadh ,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nahla\u2019a A","family":"Alabbad","sequence":"additional","affiliation":[{"name":"College of Pharmacy, King Saud University , Riyadh ,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danah A","family":"Albuaijan","sequence":"additional","affiliation":[{"name":"College of Pharmacy, King Saud University , Riyadh ,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dareen N","family":"Alassiri","sequence":"additional","affiliation":[{"name":"College of Pharmacy, King Saud University , Riyadh ,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alanoud F","family":"Aljarbua","sequence":"additional","affiliation":[{"name":"College of Pharmacy, King Saud University , Riyadh ,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatimah K","family":"Almusaytir","sequence":"additional","affiliation":[{"name":"College of Pharmacy, King Saud University , Riyadh ,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nouf M","family":"Alrasheed","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University , Riyadh ,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,1,1]]},"reference":[{"key":"2024103012041841800_CIT0001","first-page":"S1","article-title":"Definition, classification, and diagnosis of diabetes 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