{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:33:16Z","timestamp":1791361996669,"version":"4.3.1"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T00:00:00Z","timestamp":1711152000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872959"],"award-info":[{"award-number":["81872959"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81373920"],"award-info":[{"award-number":["81373920"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30801522"],"award-info":[{"award-number":["30801522"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Sichuan Province Youth Innovation Team Fund","award":["19CXTD0055"],"award-info":[{"award-number":["19CXTD0055"]}]},{"DOI":"10.13039\/501100008402","name":"Chengdu University of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["030058032"],"award-info":[{"award-number":["030058032"]}],"id":[{"id":"10.13039\/501100008402","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The effects of wild Cordyceps proteins (WCPs) on the gut microbiota and the immune system of MRL\/lpr mice were studied.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The effects of WCP on serum metabolic indexes (total triglyceride, total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol) content was measured by a biochemical analyzer. CD4+, CD8+ cells, intestinal inflammation, and intestinal barrier function in MRL\/lpr mice were measured by flow cytometry, 16S ribosomal RNA, western blot, and quantitative real-time polymerase chain reaction RT-PCR.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>The results showed that after the intervention of WCP, the content of CD4+ cells in lupus mice increased, and the levels of proinflammatory cytokines were down-regulated, such as tumor necrosis factor-\u03b1 and interleukin-6. Secondly, WCP up-regulated the proteins and mRNA levels of ZO-1, Claudin-1, and Occludin. Thirdly, it also increased the Firmicutes\/Bacteroidetes ratio and the abundance of Oscillospirales, Lachnospirales, Lachnospiraceae, and Clostridia, as well as negatively regulated the MAPK\/NF-\u043aB signaling pathway in lupus nephritis (LN) mice.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>These findings suggested that WCP may improve the symptoms of LN by altering immune factors and the intestinal barrier.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpp\/rgad118","type":"journal-article","created":{"date-parts":[[2024,3,24]],"date-time":"2024-03-24T01:12:40Z","timestamp":1711242760000},"page":"616-630","source":"Crossref","is-referenced-by-count":4,"title":["Wild Cordyceps proteins reinforce intestinal epithelial barrier through MAPK\/NF-\u03baB pathway in MRL\/lpr mice"],"prefix":"10.1093","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1674-8174","authenticated-orcid":false,"given":"Li-Ying","family":"He","sequence":"first","affiliation":[{"name":"Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, College of Pharmacy, Chengdu University of Traditional Chinese Medicine , Chengdu 611 137 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-qi","family":"Niu","sequence":"additional","affiliation":[{"name":"College of Medical Technology, Chengdu University of Traditional Chinese Medicine , Chengdu 611137 ,","place":["China"]},{"name":"Chongqing Key Laboratory of Sichuan-Chongqing Co-construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine , Chongqing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, College of Pharmacy, Chengdu University of Traditional Chinese Medicine , Chengdu 611 137 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao-jiao","family":"Fu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, College of Pharmacy, Chengdu University of Traditional Chinese Medicine , Chengdu 611 137 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Tang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, College of Pharmacy, Chengdu University of Traditional Chinese Medicine , Chengdu 611 137 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Medical 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