{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T17:28:37Z","timestamp":1784654917010,"version":"3.55.0"},"reference-count":71,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T00:00:00Z","timestamp":1711065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974542"],"award-info":[{"award-number":["81974542"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>This study was designed to investigate the pharmacological activity and therapeutic mechanism of Mahuang Xixin Fuzi decoction (MXFD) on migraine.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Migraine model rats induced by nitroglycerin were established, and then orally administered with MXFD for 7 days. Blood and urine samples were collected to identify differential metabolites with metabolomics. To integrate the findings from network pharmacology and metabolomics analysis, the metabolites and targets related to MXFD therapy for migraine were filtered.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>MXFD was found to alleviate the symptoms of migraines in rats. After treatment with MXFD, nine metabolites were found to be regulated and returned to normal levels. MXFD acted directly on nine key targets including MAOB, MAOA, ADRB1, ADRB2, ADRB3, ADORA2A, ADORA2B, DRD5, and HTR4 and regulated two out of nine metabolites, namely deoxycholic acid and 5-methoxyindoleacetate.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The study found that MXFD can alleviate migraines through multitarget and multicomponent interaction networks.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpp\/rgae025","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T17:51:05Z","timestamp":1711129865000},"page":"710-723","source":"Crossref","is-referenced-by-count":4,"title":["Integrating metabolomics and network pharmacology to assess the effects of Mahuang Xixin Fuzi decoction on migraine rats induced by nitroglycerin"],"prefix":"10.1093","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8458-1401","authenticated-orcid":false,"given":"Fei","family":"Ge","sequence":"first","affiliation":[{"name":"College of Traditional Chinese Medicine, Beijing University of Chinese Medicine , 100029 Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine, Beijing University of Chinese Medicine , 100029 Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamin","family":"Luo","sequence":"additional","affiliation":[{"name":"Bejing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine , 100029 Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunguo","family":"Wang","sequence":"additional","affiliation":[{"name":"Bejing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine , 100029 Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixing","family":"Lu","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine, Beijing University of Chinese Medicine , 100029 Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafang","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine, Beijing University of Chinese Medicine , 100029 Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine, Beijing University of Chinese Medicine , 100029 Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengxian","family":"Meng","sequence":"additional","affiliation":[{"name":"Dongfang Hospital of Beijing University of Traditional Chinese Medicine , 100078 Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing , Dongzhimen Hospital, 101121 Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine, Beijing University of Chinese Medicine , 100029 Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Tao","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine, Beijing University of Chinese Medicine , 100029 Beijing ,","place":["China"]},{"name":"Research Institute of Chinese Medicine Literature, Beijing University of Chinese Medicine , 100029 Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,6,1]]},"reference":[{"key":"2024103012043541100_CIT0001","first-page":"1866","article-title":"Migraine","volume-title":"N Engl J Med","author":"Ashina","year":"2020"},{"key":"2024103012043541100_CIT0002","first-page":"17","article-title":"Migraine is first cause of disability in under 50s: will health politicians now take notice","volume-title":"J Headache Pain","author":"Steiner","year":"2018"},{"key":"2024103012043541100_CIT0003","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(18)32279-7","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"392","author":"GBD. 2017 Disease and injury incidence and prevalence collaborators","year":"2018","journal-title":"Lancet"},{"key":"2024103012043541100_CIT0004","first-page":"165","article-title":"Burden of neurological disorders across the US from 1990\u20132017: a global burden of disease study","volume-title":"JAMA Neurol","author":"Feigin","year":"2021"},{"key":"2024103012043541100_CIT0005","first-page":"1505","article-title":"Migraine: integrated approaches to clinical management and emerging treatments","volume-title":"Lancet","author":"Ashina","year":"2021"},{"key":"2024103012043541100_CIT0006","first-page":"475","article-title":"Medication-overuse headache: a worldwide problem","volume-title":"Lancet Neurol","author":"Diener","year":"2004"},{"key":"2024103012043541100_CIT0007","first-page":"10","article-title":"Complementary and integrative medicine for episodic migraine: an update of evidence from the last 3 years","volume-title":"Curr Pain Headache Rep","author":"Wells","year":"2019"},{"key":"2024103012043541100_CIT0008","first-page":"1731","article-title":"Progress in traditional Chinese medicine for the treatment of migraine","volume-title":"Am J Chin Med","author":"Huang","year":"2020"},{"key":"2024103012043541100_CIT0009","first-page":"1011","article-title":"Systematic review and meta-analysis of traditional Chinese medicine in the treatment of migraines","volume-title":"Am J Chin Med","author":"Zhou","year":"2013"},{"key":"2024103012043541100_CIT0010","first-page":"1820","article-title":"Qualitative and quantitative analysis of the chemical constituents in Mahuang-Fuzi-Xixin decoction based on high performance liquid chromatography combined with time-of-flight mass spectrometry and triple quadrupole mass spectrometers: qualitative and quantitative analysis","volume-title":"Biomed Chromatogr","author":"Sun","year":"2016"},{"key":"2024103012043541100_CIT0011","first-page":"1475","article-title":"Clinical study on ephedra and aconite and asarum decoction in the treatment of migraine","volume-title":"Henan Tradit Chin Med","author":"Liu","year":"2022"},{"key":"2024103012043541100_CIT0012","first-page":"37","article-title":"Clinical effect of headache nine capsule combined with ephedra, epimedium, and hypocrystalline soup in the treatment of migraine and its effect on patients\u2019 serum-related indexes","volume":"40","author":"Xiao","year":"2019","journal-title":"Shaanxi J Tradit Chin Med"},{"key":"2024103012043541100_CIT0013","first-page":"110","article-title":"Traditional Chinese medicine network pharmacology: theory, methodology and application","volume-title":"Chin J Nat Med","author":"Li","year":"2013"},{"key":"2024103012043541100_CIT0014","first-page":"55","article-title":"The omics in migraine","volume-title":"J Headache Pain","author":"Lionetto","year":"2013"},{"key":"2024103012043541100_CIT0015","doi-asserted-by":"crossref","first-page":"116384","DOI":"10.1016\/j.jep.2023.116384","article-title":"Network pharmacology and experimental verification to explore the anti-migraine mechanism of Yufeng Ningxin tablet","volume":"310","author":"Yu","year":"2023","journal-title":"J Ethnopharmacol"},{"key":"2024103012043541100_CIT0016","doi-asserted-by":"crossref","first-page":"9.60.1","DOI":"10.1002\/cpns.33","article-title":"Animal model of chronic migraine-associated pain","volume":"80","author":"Moye","year":"2017","journal-title":"Curr Protoc Neurosci"},{"key":"2024103012043541100_CIT0017","first-page":"269","article-title":"Characterization of a novel model of chronic migraine","volume-title":"Pain","author":"Pradhan","year":"2014"},{"key":"2024103012043541100_CIT0018","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1093\/nar\/gky092","article-title":"UniProt: the universal protein knowledgebase","volume":"46","author":"UniProt Consortium T","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"2024103012043541100_CIT0019","first-page":"D607","article-title":"STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume-title":"Nucleic Acids Res","author":"Szklarczyk","year":"2019"},{"key":"2024103012043541100_CIT0020","first-page":"15","article-title":"Nitroglycerin as a comparative experimental model of migraine pain: from animal to human and back","volume-title":"Prog Neurobiol","author":"Demartini","year":"2019"},{"key":"2024103012043541100_CIT0021","first-page":"103","article-title":"Nitroglycerine triggers triptan-responsive cranial allodynia and trigeminal neuronal hypersensitivity","volume-title":"Brain","author":"Akerman","year":"2019"},{"key":"2024103012043541100_CIT0022","first-page":"296","article-title":"Alterations of the endocannabinoid system in an animal model of migraine: evaluation in cerebral areas of rat","volume-title":"Cephalalgia","author":"Greco","year":"2010"},{"key":"2024103012043541100_CIT0023","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.3390\/ijms20122932","article-title":"Migraine: experimental models and novel therapeutic approaches","volume":"20","author":"Tardiolo","year":"2019","journal-title":"Int J Mol Sci"},{"key":"2024103012043541100_CIT0024","first-page":"109","article-title":"Global epidemiology of migraine and its implications for public health and health policy","volume-title":"Nat Rev Neurol","author":"Steiner","year":"2023"},{"key":"2024103012043541100_CIT0025","first-page":"ITC1","article-title":"Migraine","volume-title":"Ann Intern Med","author":"Zhang","year":"2023"},{"key":"2024103012043541100_CIT0026","doi-asserted-by":"crossref","first-page":"P88","DOI":"10.1016\/j.otohns.2010.06.137","article-title":"Change in CGRP and C-fos expression in migraine rat model","volume":"143","author":"Zhu","year":"2010","journal-title":"Otolaryngol Head Neck Surg"},{"key":"2024103012043541100_CIT0027","first-page":"128","article-title":"A c-Fos activation map in nitroglycerin\/levcromakalim-induced models of migraine","volume-title":"J Headache Pain","author":"Wu","year":"2022"},{"key":"2024103012043541100_CIT0028","first-page":"93","article-title":"Structural changes of cerebellum and brainstem in migraine without aura","volume-title":"J Headache Pain","author":"Qin","year":"2019"},{"key":"2024103012043541100_CIT0029","first-page":"476","article-title":"Altered brainstem anatomy in migraine","volume-title":"Cephalalgia","author":"Marciszewski","year":"2018"},{"key":"2024103012043541100_CIT0030","first-page":"113509","article-title":"Integration of GC\u2013MS and LC\u2013MS for untargeted metabolomics profiling","volume-title":"J Pharm Biomed Anal","author":"Zeki","year":"2020"},{"key":"2024103012043541100_CIT0031","first-page":"12","article-title":"Exploring the active components and potential mechanisms of Rosa roxburghii Tratt in treating type 2 diabetes mellitus based on UPLC-Q-exactive Orbitrap\/MS and network pharmacology","volume-title":"Chin Med","author":"Shen","year":"2023"},{"key":"2024103012043541100_CIT0032","first-page":"114870","article-title":"Systematic characterization of the metabolites of defatted walnut powder extract in vivo and screening of the mechanisms against NAFLD by UPLC-Q-exactive Orbitrap MS combined with network pharmacology","volume-title":"J Ethnopharmacol","author":"Ren","year":"2022"},{"key":"2024103012043541100_CIT0033","first-page":"6596","article-title":"Metabolomics study of Angelica sinensis (Oliv.) Diels on the abnormal uterine bleeding rats by ultra-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry analysis","volume-title":"Food Sci Nutr","author":"Chen","year":"2021"},{"key":"2024103012043541100_CIT0034","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/S0022-2275(20)41143-5","article-title":"Repression of cholesterol 7 alpha-hydroxylase transcription by bile acids is mediated through protein kinase C in primary cultures of rat hepatocytes","volume":"36","author":"Stravitz","year":"1995","journal-title":"J Lipid Res"},{"key":"2024103012043541100_CIT0035","first-page":"111","article-title":"Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis","volume-title":"Nat Rev Gastroenterol Hepatol","author":"Jia","year":"2018"},{"key":"2024103012043541100_CIT0036","first-page":"507","article-title":"Nuclear factor-kappaB as a molecular target for migraine therapy","volume-title":"Ann Neurol","author":"Reuter","year":"2002"},{"key":"2024103012043541100_CIT0037","first-page":"4263","article-title":"Deoxycholic acid activates epidermal growth factor receptor and promotes intestinal carcinogenesis by ADAM17-dependent ligand release","volume-title":"J Cell Mol Med","author":"Dong","year":"2018"},{"key":"2024103012043541100_CIT0038","first-page":"308","article-title":"Roxadustat alleviates nitroglycerin-induced migraine in mice by regulating HIF-1\u03b1\/NF-\u03baB\/inflammation pathway","volume-title":"Acta Pharmacol Sin","author":"Yang","year":"2023"},{"key":"2024103012043541100_CIT0039","first-page":"18820","article-title":"Activation of TRPV1 in the spinal cord by oxidized linoleic acid metabolites contributes to inflammatory hyperalgesia","volume-title":"Proc Natl Acad Sci U S A","author":"Patwardhan","year":"2009"},{"key":"2024103012043541100_CIT0040","first-page":"153","article-title":"TRPV1 in migraine pathophysiology","volume-title":"Trends Mol Med","author":"Meents","year":"2010"},{"key":"2024103012043541100_CIT0041","first-page":"260","article-title":"Lipid phase transitions in model biomembranes. The effect of ions on phosphatidylcholine bilayers","volume-title":"Biochim Biophys Acta","author":"Chapman","year":"1977"},{"key":"2024103012043541100_CIT0042","first-page":"60","article-title":"Phospholipase C activity increases in cerebrospinal fluid from migraineurs in proportion to the number of comorbid conditions: a case-control study","volume-title":"J Headache Pain","author":"Fonteh","year":"2013"},{"key":"2024103012043541100_CIT0043","first-page":"16","article-title":"Generation of choline for acetylcholine synthesis by phospholipase D isoforms","volume-title":"BMC Neurosci","author":"Zhao","year":"2001"},{"key":"2024103012043541100_CIT0044","first-page":"1142","article-title":"Bromocriptine protects perilesional spinal cord neurons from lipotoxicity after spinal cord injury","volume-title":"Neural Regen Res","author":"Peng","year":"2024"},{"key":"2024103012043541100_CIT0045","first-page":"1421","article-title":"The role of citicoline in cognitive impairment: pharmacological characteristics, possible advantages, and doubts for an old drug with new perspectives","volume-title":"Clin Interv Aging","author":"Gareri","year":"2015"},{"key":"2024103012043541100_CIT0046","first-page":"2023.07.05.547662","article-title":"Acetylcholine release from basal forebrain promotes cortical synaptic plasticity via somatostatin interneurons","author":"Zhao","year":"2024"},{"key":"2024103012043541100_CIT0047","first-page":"955","article-title":"Hydroxyproline metabolism by the rat kidney: distribution of renal enzymes of hydroxyproline catabolism and renal conversion of hydroxyproline to glycine and serine","volume-title":"Metabolism","author":"Lowry","year":"1985"},{"key":"2024103012043541100_CIT0048","first-page":"10485","article-title":"A novel function for hydroxyproline oxidase in apoptosis through generation of reactive oxygen species","volume-title":"J Biol Chem","author":"Cooper","year":"2008"},{"key":"2024103012043541100_CIT0049","first-page":"318","article-title":"A study of oxidative stress in migraine with special reference to prophylactic therapy","volume-title":"Int J Neurosci","author":"Tripathi","year":"2018"},{"key":"2024103012043541100_CIT0050","first-page":"323","article-title":"An investigation of oxidant\/antioxidant balance in patients with migraine: a case-control study","volume-title":"BMC Neurol","author":"Togha","year":"2019"},{"key":"2024103012043541100_CIT0051","first-page":"167","article-title":"Comparison of oxidative stress among migraineurs, tension-type headache subjects, and a control group","volume-title":"Ann Indian Acad Neurol","author":"Gupta","year":"2009"},{"key":"2024103012043541100_CIT0052","first-page":"92","article-title":"Oxidative stress in migraine with and without aura","volume-title":"Biol Trace Elem Res","author":"Tuncel","year":"2008"},{"key":"2024103012043541100_CIT0053","first-page":"19","article-title":"Quantification of serotonin and eight of its metabolites in plasma of healthy volunteers by mass spectrometry","volume-title":"Clin Chim Acta","author":"Eugster","year":"2022"},{"key":"2024103012043541100_CIT0054","first-page":"1225","article-title":"Tryptophan depletion increases nausea, headache and photophobia in migraine sufferers","volume-title":"Cephalalgia","author":"Drummond","year":"2006"},{"key":"2024103012043541100_CIT0055","first-page":"48","article-title":"Vascular protection by tetrahydrobiopterin: progress and therapeutic prospects","volume-title":"Trends Pharmacol Sci","author":"Katusic","year":"2009"},{"key":"2024103012043541100_CIT0056","first-page":"1634","article-title":"Dopamine D2\/D3 imbalance during migraine attack and allodynia in vivo","volume-title":"Neurology","author":"DaSilva","year":"2017"},{"key":"2024103012043541100_CIT0057","first-page":"S153","article-title":"Dopamine genes and migraine","volume-title":"J Headache Pain","author":"Palmas","year":"2000"},{"key":"2024103012043541100_CIT0058","first-page":"17","article-title":"Phenethylamine is a substrate of monoamine oxidase B in the paraventricular thalamic nucleus","volume-title":"Sci Rep","author":"Obata","year":"2022"},{"key":"2024103012043541100_CIT0059","first-page":"503","article-title":"Effect of light on 5-methoxyindole-3-acetic acid in the rat","volume-title":"J Neural Transm (Vienna)","author":"Ho","year":"2001"},{"key":"2024103012043541100_CIT0060","first-page":"526","article-title":"Migraine is associated with high brain 5-HT levels as indexed by 5-HT4 receptor binding","volume-title":"Cephalalgia","author":"Deen","year":"2019"},{"key":"2024103012043541100_CIT0061","first-page":"e0200908","article-title":"Deoxycholic acid supplementation impairs glucose homeostasis in mice","volume-title":"PLoS One","author":"Zaborska","year":"2018"},{"key":"2024103012043541100_CIT0062","first-page":"76","article-title":"Serotonin receptor 3B polymorphisms are associated with type 2 diabetes: The Korean Genome and Epidemiology Study","volume-title":"Diabetes Res Clin Pract","author":"Kwon","year":"2019"},{"key":"2024103012043541100_CIT0063","first-page":"166","article-title":"Polymorphisms in adrenergic receptor genes in Qinchuan cattle show associations with selected carcass traits","volume-title":"Meat Sci","author":"Mei","year":"2018"},{"key":"2024103012043541100_CIT0064","first-page":"1493","article-title":"Changes in migraine characteristics over 30 days of Ramadan fasting: a prospective study","volume-title":"Headache","author":"Ragab","year":"2021"},{"key":"2024103012043541100_CIT0065","first-page":"106899","article-title":"Worsening of migraine headache with fasting Ramadan","volume-title":"Clin Neurol Neurosurg","author":"Al-Hashel","year":"2021"},{"key":"2024103012043541100_CIT0066","first-page":"12","article-title":"Migraine triggers and oxidative stress: a narrative review and synthesis","volume-title":"Headache","author":"Borkum","year":"2016"},{"key":"2024103012043541100_CIT0067","first-page":"923","article-title":"Peripheral adenosine A2A receptors are involved in carrageenan-induced mechanical hyperalgesia in mice","volume-title":"Neuroscience","author":"Li","year":"2010"},{"key":"2024103012043541100_CIT0068","first-page":"41","article-title":"Characterization of the trigeminovascular actions of several adenosine A2A receptor antagonists in an in vivo rat model of migraine","volume-title":"J Headache Pain","author":"Haanes","year":"2018"},{"key":"2024103012043541100_CIT0069","first-page":"109","article-title":"Increased dopamine is associated with the cGMP and homocysteine pathway in female migraineurs","volume-title":"Headache","author":"Gruber","year":"2010"},{"key":"2024103012043541100_CIT0070","first-page":"23","article-title":"Nitroglycerin enhances cGMP expression in specific neuronal and cerebrovascular structures of the rat brain","volume-title":"J Chem Neuroanat","author":"Tassorelli","year":"2004"},{"key":"2024103012043541100_CIT0071","first-page":"258","article-title":"Nitric oxide in migraine","volume-title":"CNS Neurol Disord Drug Targets","author":"Neeb","year":"2007"}],"container-title":["Journal of Pharmacy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/76\/6\/710\/60221881\/rgae025.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/76\/6\/710\/60221881\/rgae025.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T16:34:55Z","timestamp":1730306095000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpp\/article\/76\/6\/710\/7633714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,1]]},"references-count":71,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,6,1]]},"published-print":{"date-parts":[[2024,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jpp\/rgae025","relation":{},"ISSN":["0022-3573","2042-7158"],"issn-type":[{"value":"0022-3573","type":"print"},{"value":"2042-7158","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,6,1]]},"published":{"date-parts":[[2024,6,1]]}}}