{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T08:08:29Z","timestamp":1784448509622,"version":"3.55.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Xiaoping Chen Foundation"},{"name":"Development of Science and Technology of Hubei Province","award":["CXPJJH121003-2216"],"award-info":[{"award-number":["CXPJJH121003-2216"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Several studies have shown that propofol administration during surgery effectively attenuates remifentanil-induced hyperalgesia (RIH). Ciprofol, a novel intravenous sedative agent analogous to propofol, has not yet been proven efficacious in alleviating RIH. The present study aimed to investigate the effect of ciprofol on RIH and the possible mechanisms involved.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The RIH model was established by an infusion of remifentanil (1 \u03bcg\u00b7kg\u22121\u00b7min\u22121) 60 min in rats with incisional pain. Ciprofol (0.1, 0.25, and 0.4 mg\u00b7kg\u22121\u00b7min\u22121) was simultaneously infused to evaluate its effect on RIH. The antinociception of ciprofol was verified by measured paw withdrawal mechanical threshold (PWMT) and paw withdrawal thermal latency (PWTL). \u03b3-aminobutyric acid type A receptor \u03b12 subunit (\u03b12GABAAR), N-methyl-d-aspartate receptor NR2B subunit (NR2B), calcium\/calmodulin-dependent protein kinase II \u03b1 (CaMKII\u03b1), and phosphorylated CaMKII\u03b1 (P-CaMKII\u03b1) in the spinal cord and hippocampus of rats were assessed by western blotting and immunohistochemistry.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>The results showed that ciprofol dose-dependently increased PWMT and PWTL values in RIH rats. Moreover, ciprofol upregulated \u03b12GABAAR and downregulated NR2B and P-CaMKII\u03b1 in the rat spinal cord and hippocampus.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Ciprofol alleviates RIH effectively, and the anti-hyperalgesic mechanisms may involve increasing \u03b12GABAAR levels and decreasing NR2B and P-CaMKII\u03b1 levels in the spinal cord and hippocampus.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpp\/rgae027","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T05:24:06Z","timestamp":1711517046000},"page":"736-745","source":"Crossref","is-referenced-by-count":6,"title":["Ciprofol alleviates remifentanil-induced hyperalgesia by regulating \u03b12GABAARs, NR2B, and P-CaMKII\u03b1 levels in the spinal cord and hippocampus"],"prefix":"10.1093","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2493-7551","authenticated-orcid":false,"given":"Yang","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China , Hefei 230001, Anhui ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0064-0461","authenticated-orcid":false,"given":"Chao","family":"Yang","sequence":"additional","affiliation":[{"name":"Bengbu Medical University , Bengbu 233030, Anhui ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6345-282X","authenticated-orcid":false,"given":"Yujie","family":"Shi","sequence":"additional","affiliation":[{"name":"Bengbu Medical University , Bengbu 233030, Anhui ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1489-1965","authenticated-orcid":false,"given":"Chengyuan","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China , Hefei 230001, Anhui ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9036-4996","authenticated-orcid":false,"given":"Hanyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China , Hefei 230001, Anhui ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8453-8871","authenticated-orcid":false,"given":"Mengyuan","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China , Hefei 230001, Anhui ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7342-3379","authenticated-orcid":false,"given":"Ruyi","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China , Hefei 230001, Anhui ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2860-4784","authenticated-orcid":false,"given":"Chen","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China , Hefei 230001, Anhui ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5915-8214","authenticated-orcid":false,"given":"Min","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China , Hefei 230001, Anhui ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1704-8249","authenticated-orcid":false,"given":"Yanhu","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China , Hefei 230001, Anhui ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,6,1]]},"reference":[{"key":"2024103012044011600_CIT0001","first-page":"125","article-title":"Opioid-induced hyperalgesia: a clinical challenge","volume-title":"Br J Anaesth","author":"Colvin","year":"2010"},{"key":"2024103012044011600_CIT0002","first-page":"991","article-title":"Opioid-induced hyperalgesia in patients after surgery: a systematic review and a meta-analysis","volume-title":"Br J 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