{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T04:15:20Z","timestamp":1784952920407,"version":"3.55.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Intestinal ischemia reperfusion (IIR) is a critical emergency situation that needs immediate intervention. Small intestine is one of the most sensitive tissues to IR injury and it remains a highly morbid condition, with reported mortality rates ranging from 30% to 90%. Thus, we aimed to evaluate the suspected protective role of sacubitril\/valsartan (SAC\/VAL) on IIR injury.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Thirty-two adult male Wistar rats were used in our model and divided into four groups: sham group, SAC\/VAL treated group without IIR, IIR group, and SAC\/VAL treated group with IIR. SAC\/VAL in a dose of 30 mg\/kg was administered orally just before induction of IIR.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>SAC\/VAL significantly ameliorated IIR-induced changes as it decreased malondialdehyde (MDA), tumor necrosis factor alpha (TNF\u03b1), angiotensin II (ANG II), interleukin 6 (IL 6), active caspase 3, and signal transducer- and activator-of transcription (STAT1). However, SAC\/VAL administration significantly increased antioxidant parameters such as total antioxidant capacity (TAC), superoxide dismutase (SOD), and reduced glutathione (GSH). Moreover, alteration of the histological structure was observed in IIR group that was improved by SAC\/VAL.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>SAC\/VAL prevents IIR-induced damage via modulation of renin angiotensin aldosterone system, antioxidant, anti-apoptotic, anti-inflammatory properties, and regulation of IL6\/STAT1 pathway.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpp\/rgae031","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T01:07:30Z","timestamp":1711588050000},"page":"788-797","source":"Crossref","is-referenced-by-count":9,"title":["Sacubitril\/valsartan protective effect on induced intestinal ischemia\/reperfusion injury via immune modulation of IL6\/STAT1 pathway"],"prefix":"10.1093","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6211-9558","authenticated-orcid":false,"given":"Marwa Monier Mahmoud","family":"Refaie","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Minia University , 61511 El-Minia ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2963-5555","authenticated-orcid":false,"given":"Entesar Farghly","family":"Amin","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Minia University , 61511 El-Minia ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5129-6361","authenticated-orcid":false,"given":"Marwa Nadi","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Minia University , 61511 El-Minia ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7481-2656","authenticated-orcid":false,"given":"Rehab Ahmed","family":"Rifaai","sequence":"additional","affiliation":[{"name":"Department of Histology and Cell Biology, Faculty of Medicine, Minia University , 61511 El-Minia ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6757-2431","authenticated-orcid":false,"given":"Asmaa M A","family":"Bayoumi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy, Minia University , 61519 El-Minia ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7557-7873","authenticated-orcid":false,"given":"Maha Yehia","family":"Kamel","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Minia University , 61511 El-Minia 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