{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:43:06Z","timestamp":1777531386170,"version":"3.51.4"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["309461\/2020-0"],"award-info":[{"award-number":["309461\/2020-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Angico gum (AG) (Anadenanthera colubrina var. Cebil [Griseb.] Altschul) is utilized by some Brazilian communities to alleviate symptoms from gastroesophageal reflux disease. Here, we aimed to investigate the \u201cin vitro\u201d topical protective capacity of AG on human esophageal mucosa.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Biopsies of the distal esophageal mucosa were collected from 35 patients with heartburn (24 non-erosive and 11 with erosive oesophagitis (EE)) and mounted in \u00dcssing chambers. AG was applied topically, followed by exposure with acid solution (pH 2.0 or pH 1.0), where transepithelial electrical resistance (TER) and The transepithelial permeability for fluorescein was assessed. The incubation of the AG labeled with FITC in the esophageal mucosa was localized by fluorescence microscopy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key findings<\/jats:title>\n                  <jats:p>Pretreatment with AG prevented the drop in TER induced by acid solution, as well as significantly decreases the fluorescein permeability in non-erosive patients. The protective effect of AG was sustained for up to 120 min both in biopsies of non-erosive and erosive esophagitis. Confocal microscope images showed mucosal luminal adherence of FITC-labeled AG.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>AG had a prolonged topical protective effect against acid solution in mucosal biopsies of patients with non-erosive and erosive esophagitis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpp\/rgae032","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T15:01:40Z","timestamp":1711638100000},"page":"732-742","source":"Crossref","is-referenced-by-count":2,"title":["Exploring the clinical relevance of \u201cAngico Gum\u201d: an effective biopolymer for topical protection of oesophageal mucosa in gastroesophageal reflux disease patients"],"prefix":"10.1093","volume":"76","author":[{"given":"Rudy Diavila","family":"Bingana","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology, Federal University of Cear\u00e1 , Coronel Nunes de Melo Street, 1315, Fortaleza, CE 60430-275 ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas Antonio Duarte","family":"Nicolau","sequence":"additional","affiliation":[{"name":"Lab of Inflammation and Translational Gastroenterology, Parna\u00edba Delta Federal University , S\u00e3o Sebasti\u00e3o Avenue, 2819, Parna\u00edba, PI 64202-020 ,","place":["Brazil"]},{"name":"Department of Biochemistry and Pharmacology, Federal University of Piau\u00ed , Campus Univesit\u00e1rio Ministro Petr\u00f4nio Portela, Teresina, PI 64049-550 ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thiago Meneses Ara\u00fajo Leite","family":"Sales","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Federal University of Cear\u00e1 , Coronel Nunes de Melo Street, 1315, Fortaleza, CE 60430-275 ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suliana Mesquita","family":"Paula","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Federal University of Cear\u00e1 , Coronel Nunes de Melo Street, 1315, Fortaleza, CE 60430-275 ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Pedro","family":"do Carmo Neto","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Federal University of Cear\u00e1 , Coronel Nunes de Melo Street, 1315, Fortaleza, CE 60430-275 ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabela Ara\u00fajo Linhares","family":"Castro","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Federal University of Cear\u00e1 , Coronel Nunes de Melo Street, 1315, Fortaleza, CE 60430-275 ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Fernando Lopes Soares","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Lab of Inflammation and Translational Gastroenterology, Parna\u00edba Delta Federal University , S\u00e3o Sebasti\u00e3o Avenue, 2819, Parna\u00edba, PI 64202-020 ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alvaro Xavier","family":"Franco","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Federal University of Cear\u00e1 , Coronel Nunes de Melo Street, 1315, Fortaleza, CE 60430-275 ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1bio de Oliveira Silva","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Lab of Inflammation and Translational Gastroenterology, Parna\u00edba Delta Federal University , S\u00e3o Sebasti\u00e3o Avenue, 2819, Parna\u00edba, PI 64202-020 ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina C\u00e9lia Monteiro","family":"de Paula","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Federal University of Cear\u00e1 , Humberto Monte Avenue, Campus do Pici, Fortaleza, CE 60.440-900 ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7234-3382","authenticated-orcid":false,"given":"Jand Venes Rolim","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Lab of Inflammation and Translational Gastroenterology, Parna\u00edba Delta Federal University , S\u00e3o Sebasti\u00e3o Avenue, 2819, Parna\u00edba, PI 64202-020 ,","place":["Brazil"]},{"name":"Department of Biochemistry and Pharmacology, Federal University of Piau\u00ed , Campus Univesit\u00e1rio Ministro Petr\u00f4nio Portela, Teresina, PI 64049-550 ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Durcilene Alves","family":"da Silva","sequence":"additional","affiliation":[{"name":"Lab of Inflammation and Translational Gastroenterology, Parna\u00edba Delta Federal University , S\u00e3o Sebasti\u00e3o Avenue, 2819, Parna\u00edba, PI 64202-020 ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Sifrim","sequence":"additional","affiliation":[{"name":"Barts and the London School of Medicine and Dentistry, Queen Mary University of London , 26 Ashfield Street, London E1 2AJ26 ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2376-3433","authenticated-orcid":false,"given":"Marcellus Henrique Loiola Ponte","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Federal University of Cear\u00e1 , Coronel Nunes de Melo Street, 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