{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:14:41Z","timestamp":1791245681808,"version":"4.1.0"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Anadolu University Research Foundation","award":["AUBAP- 2004S01"],"award-info":[{"award-number":["AUBAP- 2004S01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We purposed to explore the consequences of the use quercetin and fisetin alone and in combination with pregabalin and gabapentin, which are used in the management of neuropathic pain, and on neuropathic pain in general. The anti-allodynic effect of various doses (5, 10, and 20 mg\/kg) of quercetin and fisetin, both singly and in combination with pregabalin and gabapentin, was evaluated by developing a neuropathic pain model induced by chronic constrictive nerve damage in rats. The effectiveness of these flavonoids was investigated by combining them with gabapentin (50 mg\/kg) and pregabalin (15 mg\/kg), choosing the effectual dose of 10 mg\/kg and the dose of 5 mg\/kg, which did not show significant antiallodynic effects. In groups combined with gabapentin and pregabalin, it was determined that they showed a significant antiallodynic effect compared with 50 mg\/kg gabapentin and 15 mg\/kg pregabalin. In conclusion, in our combination studies, it was observed that the effectiveness of gabapentin and pregabalin, was increased and the duration of effect was prolonged when used with lower doses of flavonoids. Based on these findings; it is possible to say that quercetin and fisetin are potential agents that can be used alone or in combination with other effective treatments to alleviate neuropathic pain.<\/jats:p>","DOI":"10.1093\/jpp\/rgae034","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T19:30:41Z","timestamp":1712604641000},"page":"824-833","source":"Crossref","is-referenced-by-count":5,"title":["Use of kersetin and fisetin flavonoids in combination with pregabalin and gabapentin in the treatment of neuropathic pain"],"prefix":"10.1093","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2054-4542","authenticated-orcid":false,"given":"Elif","family":"Karabacak","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Anadolu University, Graduate School of Education , Eskisehir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hazal","family":"Eken","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Afyonkarahisar Health Sciences, University Faculty of Pharmacy , Afyon, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9876-9106","authenticated-orcid":false,"given":"Ilhem","family":"Dallali","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Anadolu University, Graduate School of Education , Eskisehir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana","family":"Arslan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Anadolu University, Faculty of Pharmacy , Eskisehir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,7,1]]},"reference":[{"key":"2024110501465348500_CIT0001","first-page":"167","article-title":"Chronic pain: Where the body meets the brain","volume":"126","author":"Crofford","year":"2015","journal-title":"Trans Am Clin Climatol Assoc"},{"key":"2024110501465348500_CIT0002","first-page":"1","article-title":"Neuropathic pain","volume-title":"Nat Rev Dis Primers","author":"Colloca","year":"2017"},{"key":"2024110501465348500_CIT0003"},{"key":"2024110501465348500_CIT0004","first-page":"5","article-title":"Mekanizmalar, tan\u0131 ve tedavi","volume":"17","author":"Yucel","year":"2005","journal-title":"Agr\u0131"},{"key":"2024110501465348500_CIT0005","first-page":"1","article-title":"Ameliorative potential of Alstonia scholaris (Linn.) 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