{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:12:12Z","timestamp":1790691132713,"version":"4.1.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,6,2]],"date-time":"2024-06-02T00:00:00Z","timestamp":1717286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82205193"],"award-info":[{"award-number":["82205193"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82004421"],"award-info":[{"award-number":["82004421"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974579"],"award-info":[{"award-number":["81974579"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Development Plan Project of Jilin Provincial","award":["20210101240JC"],"award-info":[{"award-number":["20210101240JC"]}]},{"name":"2023 Youth Excellent Discipline Backbone Training Project of Changchun University of Traditional Chinese Medicine","award":["202302"],"award-info":[{"award-number":["202302"]}]},{"name":"Scientific Research Project of Jilin Provincial Department of Education","award":["JJKH20230959KJ"],"award-info":[{"award-number":["JJKH20230959KJ"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>We aim to investigate the effect of YiQi GuBen formula (YQGB) on airway inflammation and airway remodeling in the ovalbumin (OVA)-induced asthma model to further explore the potential mechanisms of YQGB in treating allergic asthma.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Mice were divided into five groups randomly (n = 10): the control group, OVA group, OVA + Dex (0.1 mg\/kg) group, OVA + low-dose (1.1 g\/kg) YQGB group, and OVA + high-dose (2.2 g\/kg) YQGB group. Inflammatory cell count and IgE were detected in bronchoalveolar lavage fluid (BALF). Lung tissue histopathology was observed by using H&amp;E, PAS, Masson, and immunohistochemistry staining. qRT-PCR and western blot were applied to analyze key genes and proteins associated with TLR4 and NF-\u03baB signaling pathways.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In OVA-induced asthma mice, YQGB decreased eosinophils and IgE in BALF. YQGB alleviated the OVA-induced inflammatory infiltration and declined IL-4, IL-5, IL-13, Eotaxin, ECP, GM-CSF, LTC4, and LTD4. YQGB attenuated the OVA-induced goblet cell metaplasia and mucus hypersecretion. YQGB mitigated the OVA-induced subepithelial fibrosis and lowered TGF-\u03b21, E-Cadherin, Vimentin, and Fibronectin. YQGB ameliorated the OVA-induced airway smooth muscle thickening and lessened \u03b1-SMA and PDGF levels. YQGB reduced the expression of TLR4, MyD88, TRAF6, I\u03baB\u03b1, and p65 mRNAs, and I\u03baB\u03b1 and p-p65 protein levels were also reduced.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>YQGB exhibits the anti-asthma effect by reducing airway inflammation and airway remodeling through suppressing TLR4\/NF-\u03baB signaling pathway, and is worth promoting clinically.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpp\/rgae064","type":"journal-article","created":{"date-parts":[[2024,6,2]],"date-time":"2024-06-02T12:21:18Z","timestamp":1717330878000},"page":"1028-1037","source":"Crossref","is-referenced-by-count":5,"title":["YiQi GuBen formula alleviates airway inflammation and airway remodeling in OVA-induced asthma mice through TLR4\/NF-\u03baB signaling pathway"],"prefix":"10.1093","volume":"76","author":[{"given":"Yibu","family":"Kong","sequence":"first","affiliation":[{"name":"College of Traditional Chinese Medicine, Changchun University of Chinese Medical , No.1035, Boshuo Road, Jingyue District, Changchun 130017 ,","place":["China"]},{"name":"Department of Pediatrics, The Affiliated Hospital to Changchun University of Chinese Medicine , No. 1478, Gongnong Road, Chaoyang District, Changchun 130021, Jilin ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongtian","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine, Changchun University of Chinese Medical , No.1035, Boshuo Road, Jingyue District, Changchun 130017 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjun","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Affiliated Hospital to Changchun University of Chinese Medicine , No. 1478, Gongnong Road, Chaoyang District, Changchun 130021, Jilin ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiai","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Affiliated Hospital to Changchun University of Chinese Medicine , No. 1478, Gongnong Road, Chaoyang District, Changchun 130021, Jilin ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongfu","family":"Song","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine, Changchun University of Chinese Medical , No.1035, Boshuo Road, Jingyue District, Changchun 130017 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Affiliated Hospital to Changchun University of Chinese Medicine , No. 1478, Gongnong Road, Chaoyang District, Changchun 130021, Jilin ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinpu","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine, Changchun University of Chinese Medical , No.1035, Boshuo Road, Jingyue District, Changchun 130017 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Affiliated Hospital to Changchun University of Chinese Medicine , No. 1478, Gongnong Road, Chaoyang District, Changchun 130021, Jilin ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9152-4033","authenticated-orcid":false,"given":"Yinan","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine, Changchun University of Chinese Medical , No.1035, Boshuo Road, Jingyue District, 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