{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:14:16Z","timestamp":1790784856763,"version":"4.1.0"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81874368"],"award-info":[{"award-number":["81874368"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Traditional Chinese Medicine","award":["2021ZY038"],"award-info":[{"award-number":["2021ZY038"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Breast cancer is a malignant tumor with high invasion and metastasis. TGF-\u03b21-induced epithelial-mesenchymal transition (EMT) is crucially involved in the growth and metastasis of breast cancer. Wedelolactone (Wed) is extracted from herbal medicine Ecliptae Herba, which is reported to have antineoplastic activity. Here, we aimed to elucidate the efficacy and mechanism of Wed against breast cancer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The effects of Wed on migration and invasion of 4T1 were detected. The expression of EMT-related markers was detected by Western blot and qPCR. The 4T1 orthotopic murine breast cancer model was established to evaluate the therapeutic effect of Wed on the growth and metastasis of breast cancer through TGF-\u03b21\/Smad pathway.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Wed inhibited the proliferation, migration and invasion of 4T1. It exhibited concentration-dependent inhibition of p-Smad2\/3. Wed also reversed the expression of EMT-markers induced by TGF-\u03b21. In addition, Wed suppressed the growth and metastasis of breast cancer in mice. It also affected p-Smad3 expression as well as EMT-related genes, suggesting that its anti-breast cancer effect may be related to the TGF-\u03b21\/Smad pathway.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Wed reverses EMT by regulating TGF-\u03b21\/Smad pathway, potentially serving as a therapeutic agent for breast cancer. Wed is expected to be a potential drug to inhibit TGF-\u03b21\/Smad pathway-related diseases.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpp\/rgae065","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T18:40:13Z","timestamp":1717785613000},"page":"1038-1050","source":"Crossref","is-referenced-by-count":11,"title":["Wedelolactone suppresses breast cancer growth and metastasis via regulating TGF-\u03b21\/Smad signaling pathway"],"prefix":"10.1093","volume":"76","author":[{"given":"Hui","family":"Li","sequence":"first","affiliation":[{"name":"School of Chinese Materia Medica, Beijing University of Chinese Medicine , Beijing 102488 ,","place":["China"]},{"name":"Department of Hepatology, The Fifth Medical Center of PLA General Hospital , Beijing 100039 ,","place":["China"]},{"name":"China Military Institute of Chinese Materia, The Fifth Medical Center of PLA General Hospital , Beijing 100039 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manting","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Hepatology, The Fifth Medical Center of PLA General Hospital , Beijing 100039 ,","place":["China"]},{"name":"China Military Institute of Chinese Materia, The Fifth Medical Center of PLA General Hospital , Beijing 100039 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Medical Supplies Center of PLA General Hospital , Beijing 100853 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutong","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Inner Mongolia People\u2019s Hospital , Hohhot 010010 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Beijing University of Chinese Medicine , Beijing 102488 ,","place":["China"]},{"name":"Department of Hepatology, The Fifth Medical Center of PLA General Hospital , Beijing 100039 ,","place":["China"]},{"name":"China Military Institute of Chinese Materia, The Fifth Medical Center of PLA General Hospital , Beijing 100039 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Zou","sequence":"additional","affiliation":[{"name":"School of Food and Biological Engineering, Chengdu University , Chengdu 610106 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junling","family":"Cao","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Beijing University of Chinese Medicine , Beijing 102488 ,","place":["China"]},{"name":"Dongzhimen Hospital, Beijing University of Chinese Medicine , Beijing 100700 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6208-150X","authenticated-orcid":false,"given":"Zhaofang","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Hepatology, The Fifth Medical Center of PLA General Hospital , Beijing 100039 ,","place":["China"]},{"name":"China Military Institute of Chinese Materia, The Fifth Medical Center of PLA General Hospital , Beijing 100039 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,8,1]]},"reference":[{"key":"2024110501471827100_CIT0001","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 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