{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:24:31Z","timestamp":1782962671717,"version":"3.54.5"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Our research focused on plant\u2019s ethanolic extract Lavandula stoechas flower part to investigate the potential analgesic effects and possible pathways involvements.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Four experimental tests were performed on Swiss albino mice with five animals in each group at different doses (50, 100, and 200mg\/kg); formalin test, tail-flick test, acetic acid-induced writhing, and hot-plate test. The opioidergic, noradrenergic, cholinergic, and K channel blockers in the analgesic actions were also carried out for the potential route involvement.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key finding<\/jats:title>\n                  <jats:p>The percentage inhibition for abdominal writhing\u2019s and formalin activity showed a dose-dependent manner for early and late phases reducing abdominal writhing\u2019s and time period of licking, respectively. Tail immersion and hot-plate test demonstrated a substantial and dose-dependent increase in the latency time and time period of paw liking and jumping response respectively. GC\u2013MS showed the abundantly present compounds were octadecatrienoic acid (34.35%), n-hexadecanoic acid (12.98%). In silico analyses have revealed three compounds that had good interactions with 6y3c receptor proteins, demonstrating strong binding affinities and satisfying docking parameters.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Overall, these studies showed that ethanolic extract of L. stoechas is an important medicinal plant, with both central and peripheral antinociceptive and analgesic activities supporting its traditional use for therapeutic purposes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpp\/rgae072","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T15:29:30Z","timestamp":1720625370000},"page":"1178-1198","source":"Crossref","is-referenced-by-count":7,"title":["<i>In vivo<\/i> and <i>in silico<\/i> elucidation of possible potential and mechanisms involved in the analgesic action of ethanolic extract of <i>Lavandula Stoechas<\/i>"],"prefix":"10.1093","volume":"76","author":[{"given":"Muhammad Muzammil","family":"Nazir","sequence":"first","affiliation":[{"name":"Government College University Department of Zoology, , Faisalabad 38000,","place":["Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sana","family":"Inam","sequence":"additional","affiliation":[{"name":"Government College University Department of Pharmaceutics, , Faisalabad 38000 ,","place":["Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Umar","family":"Ijaz","sequence":"additional","affiliation":[{"name":"University of Agriculture Department of Zoology, Wildlife and Fisheries, , Faisalabad 38040,","place":["Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimrah","family":"Zafar","sequence":"additional","affiliation":[{"name":"Government College University Department of Zoology, , Faisalabad 38000,","place":["Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derya Karatas","family":"Yeni","sequence":"additional","affiliation":[{"name":"University of Necmettin Erbakan Department of Microbiology, , Konya,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farkhanda","family":"Asad","sequence":"additional","affiliation":[{"name":"Government College University Department of Zoology, , Faisalabad 38000,","place":["Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iqra","family":"Farzeen","sequence":"additional","affiliation":[{"name":"Government College University Department of Zoology, , Faisalabad 38000,","place":["Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7026-670X","authenticated-orcid":false,"given":"Asma","family":"Ashraf","sequence":"additional","affiliation":[{"name":"Government College University Department of Zoology, , Faisalabad 38000,","place":["Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,9,1]]},"reference":[{"key":"2024103012044175300_CIT0001","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1097\/j.pain.0000000000001939","article-title":"The revised IASP definition of pain: Concepts, challenges, and compromises","volume":"161","author":"Raja","year":"2020","journal-title":"Pain"},{"key":"2024103012044175300_CIT0002","doi-asserted-by":"crossref","first-page":"113253","DOI":"10.1016\/j.biopha.2022.113253","article-title":"Antinociceptive effect of Mansoa alliacea polar extracts involves opioid receptors and nitric oxide in experimental nociception in mice","volume":"152","author":"Valle-Dorado","year":"2022","journal-title":"Biomed Pharmacother Biomed Pharmacother"},{"key":"2024103012044175300_CIT0003","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1159\/000478015","article-title":"Antinociceptive activity of methanol extract of Tabebuia hypoleuca (C. 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