{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:06:56Z","timestamp":1740136016853,"version":"3.37.3"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T00:00:00Z","timestamp":1721260800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Recent studies have suggested that serum autotaxin (ATX) may be a promising diagnostic biomarker in differentiating between Graves\u2019 disease (GD) and thyroiditis, as well as serving as a monitoring biomarker for GD. This study will evaluate the use of serum ATX as a diagnostic biomarker in these conditions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In this prospective interventional study, blood samples were collected from the patients who met both inclusion and exclusion criteria, and serum ATX levels were measured by using the MyBioSource human Autotaxin ELISA kit.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 32 patients were enrolled, of which 18.8% were newly diagnosed with GD, 21.9% were thyroiditis, and 59.3% were on treatment for GD. Serum autotaxin antigen was significantly higher in GD patients than in thyroiditis (603.3217 \u00b1 444.24 v\/s 214.74 \u00b1 55.91, P = &amp;lt;.005). Serum ATX measurement successfully discriminated GD patients from thyroiditis (AUC = 0.952, 95%CI: 0.00\u20131.00) with an optimal cutoff value of \u2265257.20 ng\/L (sensitivity = 100 and specificity = 81.71). Monitoring the efficacy of serum ATX was analyzed and showed a significant difference.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The serum ATX was higher in subjects with GD as compared to thyroiditis, and ATX levels were found to be decreased during the treatment period. In conclusion, serum ATX can be used as a diagnostic and monitoring biomarker in GD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpp\/rgae073","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T08:39:08Z","timestamp":1721378348000},"page":"56-63","source":"Crossref","is-referenced-by-count":0,"title":["Serum autotaxin level: a promising diagnostic biomarker in differentiating Graves\u2019 disease and thyroiditis"],"prefix":"10.1093","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0714-6841","authenticated-orcid":false,"given":"Angel","family":"George","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice, Nirmala College of Pharmacy , Muvattupuzha, Ernakulam, Kerala 686661 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8187-9631","authenticated-orcid":false,"given":"Anns","family":"Mariya","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Nirmala College of Pharmacy , Muvattupuzha, Ernakulam, Kerala 686661 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4021-2809","authenticated-orcid":false,"given":"Manu","family":"Eappen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Nirmala College of Pharmacy , Muvattupuzha, Ernakulam, Kerala 686661 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9242-2574","authenticated-orcid":false,"given":"Marimuthu","family":"Karthikeyan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Grace College of Pharmacy , Palakkad, Kerala 678004,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravindranath","family":"Sreenath","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Caritas Hosptial , Thellakom, Kottayam 686630 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,7,18]]},"reference":[{"key":"2025010605505735600_CIT0001","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1007\/s40618-014-0097-2","article-title":"Extrathyroidal manifestations of Graves\u2019 disease: a 2014 update","volume":"37","author":"Bartalena","year":"2014","journal-title":"J Endocrinol Invest"},{"key":"2025010605505735600_CIT0002","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.emc.2013.12.001","article-title":"Hyperthyroidism and thyrotoxicosis","volume":"32","author":"Devereaux","year":"2014","journal-title":"Emerg Med Clin North Am"},{"key":"2025010605505735600_CIT0003","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1056\/NEJMra1510030","article-title":"Graves\u2019 disease","volume":"375","author":"Smith","year":"2016","journal-title":"N Engl J Med"},{"key":"2025010605505735600_CIT0004","doi-asserted-by":"publisher","first-page":"939","DOI":"10.3390\/cells10040939","article-title":"The expression regulation and biological function of autotaxin","volume":"10","author":"Zhang","year":"2021","journal-title":"Cells"},{"key":"2025010605505735600_CIT0005","doi-asserted-by":"publisher","first-page":"e117","DOI":"10.1016\/j.clml.2022.12.006","article-title":"A diagnostic impact of serum autotaxin levels in patients with bone marrow fibrosis","volume":"23","author":"Nakazawa","year":"2023","journal-title":"Clinical Lymphoma, Myeloma & Leukemia"},{"key":"2025010605505735600_CIT0006","doi-asserted-by":"publisher","first-page":"3189","DOI":"10.1080\/07853890.2022.2143554","article-title":"Decrease in serum levels of autotaxin in COVID-19 patients","volume":"54","author":"Shimura","year":"2022","journal-title":"Ann Med"},{"key":"2025010605505735600_CIT0007","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.5958\/0974-360X","article-title":"Prevalence of thyroid disroders in India: an overview","volume":"7","author":"Subasree","year":"2014","journal-title":"Research J Pharm and Tech"},{"key":"2025010605505735600_CIT0008","doi-asserted-by":"publisher","first-page":"178","DOI":"10.4329\/wjr.v5.i4.178","article-title":"Role of color Doppler in differentiation of Graves\u2019 disease and thyroiditis in thyrotoxicosis","volume":"5","author":"Donkol","year":"2013","journal-title":"World J. 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