{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T10:22:26Z","timestamp":1773310946775,"version":"3.50.1"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Acute liver injury (ALI) is a serious syndrome with a high mortality rate due to viral infection, toxic exposure, and autoimmunity, and its severity can range from mildly elevated liver enzymes to severe liver failure. Activation of the nod-like receptor pyrin domain-containing 3 (NLRP3) inflammasome is closely associated with the development of ALI, and the search for an inhibitor targeting this pathway may be a novel therapeutic option. Anoectochilus roxburghii polysaccharide (ARP) is a biologically active ingredient extracted from Anoectochilus roxburghii with immunomodulatory, antioxidant, and anti-inflammatory bioactivities and pharmacological effects. In this study, we focused on D-galactosamine (D-GalN)\/lipopolysaccharide (LPS)-induced acute liver injury by ARP through inhibition of NLRP3 inflammasome.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>An inflammasome activation model was established in bone marrow-derived macrophages (BMDMs) to investigate the effects of ARP on caspase-1 cleavage, IL-1\u03b2 secretion, and ASC oligomerization in inflammasomes under different agonists. We used the D-GalN\/LPS-induced acute liver injury model in mice, intraperitoneally injected ARP or MCC950, and collected liver tissues, serum, and intraperitoneal lavage fluid for pathological and biochemical indexes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>ARP effectively inhibited the activation of the NLRP3 inflammasome and had an inhibitory effect on non-classical NLRP3, AIM2, and NLRC4 inflammasomes. It also effectively inhibited the oligomerization of apoptosis-associated speck-like protein (ASC) from a variety of inflammatory vesicles. Meanwhile, ARP has good therapeutic effects on acute liver injury induced by D-GaIN\/LPS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The inhibitory effect of ARP on a wide range of inflammasomes, as well as its excellent protection against acute liver injury, suggests that ARP may be a candidate for acute liver injury.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpp\/rgae077","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T17:12:18Z","timestamp":1720631538000},"page":"1212-1224","source":"Crossref","is-referenced-by-count":7,"title":["<i>Anoectochilus roxburghii<\/i> polysaccharide reduces D-GalN\/LPS-induced acute liver injury by regulating the activation of multiple inflammasomes"],"prefix":"10.1093","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0938-9408","authenticated-orcid":false,"given":"Yulu","family":"Yan","sequence":"first","affiliation":[{"name":"Ningde Hospital of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine , Fujian, 352100 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiqi","family":"Ye","sequence":"additional","affiliation":[{"name":"Ningde Hospital of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine , Fujian, 352100 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunqing","family":"Huang","sequence":"additional","affiliation":[{"name":"Ningde Hospital of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine , Fujian, 352100 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junjun","family":"Wu","sequence":"additional","affiliation":[{"name":"Ningde Hospital of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine , Fujian, 352100 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunbiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Pingnan County Hospital of Traditional Chinese Medicine , Ningde City, Fujian Province, 352300 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pingping","family":"Zheng","sequence":"additional","affiliation":[{"name":"Shouning County Hospital of Traditional Chinese Medicine , Ningde City, Fujian Province, 355500 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Congqi","family":"Shen","sequence":"additional","affiliation":[{"name":"Shanxi University of Traditional Chinese Medicine , 030619 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